2018
DOI: 10.18632/aging.101449
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Has erratum 2018-9-22Has correction 2018-9-22
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Abstract: Superovulation procedures and assisted reproductive technologies have been widely used to treat couples who have infertility problems. Although generally safe, the superovulation procedures are associated with a series of complications, such as ovarian hyper-stimulation syndrome, thromboembolism, and adnexal torsion. The role of long-term repeated superovulation in ovarian aging and especially in associated disorders such as osteoporosis and cardiovascular diseases is still unclear. In this study, we sought to… Show more

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Cited by 12 publications
(8 citation statements)
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References 50 publications
(46 reference statements)
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“…8-OHdG is a hallmark product of DNA damage caused by oxidative stress. Repeated COS can increase the 8-OHdG level in mice 10 , and a high level of 8-OHdG in ovarian GCs is associated with a low fertilization rate of oocytes and poor embryo quality during IVF 41 . Our study confirmed that the ovarian GCs and FF of patients with repeated COS (placebo group) did show higher levels of 8-OHdG.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…8-OHdG is a hallmark product of DNA damage caused by oxidative stress. Repeated COS can increase the 8-OHdG level in mice 10 , and a high level of 8-OHdG in ovarian GCs is associated with a low fertilization rate of oocytes and poor embryo quality during IVF 41 . Our study confirmed that the ovarian GCs and FF of patients with repeated COS (placebo group) did show higher levels of 8-OHdG.…”
Section: Discussionmentioning
confidence: 99%
“…Experimental studies have shown that repeated COS causes mitochondrial damage in animal reproductive cells, resulting in a decreased mitochondrial DNA copy number, increased DNA fragmentations, an abnormal distribution, and ultrastructural changes 6 9 . Moreover, animal experiments have confirmed that repeated COS increases the reactive oxygen species (ROS) level and 8-hydroxy-2-deoxyguanosine (8-OHdG) and 4-hydroxynonenal (4-HNE) concentrations in the ovaries 10 . Therefore, it is necessary to resolve the issues associated with repeated COS and improve pregnancy outcomes.…”
Section: Introductionmentioning
confidence: 96%
“…It is important to mention that literature supports the notion that the "hazard" or the individual LB probability of each woman within a particular cohort does not remain constant over different treatment cycles. In fact, in mice, repeated superovulation cycles may induce over-expression and over-activation of proteins controlling cell cycle progression in fallopian tubes [22]; alter mitochondrial functions of cumulus cells [23], impair oocyte spindle [23]; and affect ovarian function and decrease the ovarian reserve, fertility, and fecundity [24]. In humans, repeated ovarian stimulation in oocyte donation cycles does not seem to have any adverse effect on number of oocytes collected, oocyte quality, fertilization, preimplantation embryo qualities, and embryo implantation in oocyte recipients [25].…”
Section: Discussionmentioning
confidence: 99%
“…Repeated ovulation promotion increased the number of abnormal mitochondria in mouse oocytes, reduced the volume of the primordial follicular pool, decreased serum AMH levels and significantly inhibited embryo development [ 137 ]. This process also significantly increases the risk of long-term complications such as osteoporosis and cardiovascular disease [ 138 ]. In contrast, oral contraceptives have been shown to alleviate age-related ovarian aging and fertility decline by suppressing ovulation [ 139 ].…”
Section: Factors Related To Os That Lead To Ovarian Agingmentioning
confidence: 99%