Repeated intravenous cocaine administration: Locomotor activity and dopamine D2/D3 receptors

Altered Behavioral Response to Dopamine D3 Receptor Agonists 7-OH-DPAT and PD 128907 Following Repetitive Amphetamine Administration

“…Consistent with the proposed hypothesis, the D3 antagonist nafadotride inhibits locomotor sensitization to amphetamine (Richtand et al, 2000). Additionally, D3 receptor binding is reduced in nucleus accumbens following cocaine-induced locomotor sensitization (Wallace et al, 1996). Third, other manipulations augmenting responsiveness to stimulant drugs such as exposure to stress in uteroand neonatal hippocampal lesion downregulate D3 receptor binding in nucleus accumbens (Henry et al, 1995;Flores et al, 1996).…”

Factors Underlying +/- 3, 4-Methylenedioxymethamphetamine Self Administration

“…SCH233390 (0.2mg/kg) delayed the locomotor activating effects of MDMA and excitation of striatal neurons, while eticlopride (0.2mg/kg) administration attenuated MDMA -induced locomotion and neuronal excitation (Ball et al 2003). The reduction in MDMA -induced locomotion seen after dopamine antagonism was also comparable to studies reporting DA antagonism of the locomotor activating effects of amphetamine and cocaine (Gold et al 1989, Kelley & Lang 1989, Piazza et al 1991, Wallace et al 1996.…”

Risperidone Pretreatment Prevents Elevated Locomotor Activity Following Neonatal Hippocampal Lesions

“…The loss of a D3 receptor-mediated 'brake' on these behaviors would be expressed as the emergence of augmented locomotor response to amphetamine in rodents and paranoid psychotic symptoms in humans. We (Richtand et al, 2000(Richtand et al, , 2003 and others (Chiang et al, 2003;Wan and Corbett, 1997;Flores et al, 1996a;Henry et al, 1995;Wallace et al, 1996) have described evidence supporting this hypothesis in rodent behavioral sensitization and other 'animal models' of psychosis.…”