Repeated Botulinum Toxin Type A Injections to Treat Patients With Frey Syndrome

Abstract

In patients with Frey syndrome, repeated treatment with intracutaneous injection of botulinum toxin type A lowered subjective symptom scores, decreased the size of the affected area, and increased the duration of the effect.

Botulinum toxin therapy in Frey's syndrome: a retrospective study of 440 treatments in 100 patients

“…We could not confirm previous reports on increased duration of effect and prolonged symptom‐free intervals after repeated treatment with BoNT . Initial time intervals (mean 5.2 months) in the prospective trial of de Bree et al .…”

“…In agreement with previous data, 9,10,20 12 The median dosage of ABoNT was 200.0 U per patient in the present study. We visualised the affected area using Minor test before each treatment, treated the sweating area only and applied a constant dose of BoNT per cm 2 .…”

“…De Bree et al . recommended the injection of 7.5 U/0.1 mL of ABoNT per 4 cm 2 of affected area . The median dosage of ABoNT was 200.0 U per patient in the present study.…”

“…Thus, we could not confirm a decrease of affected sweating area after repeated treatments. Too short intertreatment intervals (<3 months), short follow‐up time (<1 year) and small size of patients’ series might have simulated decreasing size of the sweating area and prolonged duration of effect after repeated BoNT injections in other studies . However, the applied ABoNT dosage varied significantly in patients during analysed time in the present trial (Fig.…”

Botulinum toxin for Frey's syndrome: a closer look at different treatment responses

“…Of special interest are those Frey's syndrome patients who, following botulinum toxin treatment, demonstrate relapse of gustatory sweating within the pharmacologically effective period (i.e. type C response with early relapse); such cases are unusual but not rare 6 , 19 . Our analysis revealed no special characteristics in these patients (e.g.…”