Repeated application of photodynamic and antibiotic therapy as an adjunct to root surface debridement in patients with grade C and stage III or IV aggressive periodontitis

Al-Khureif, Abdulaziz Abdullah; Mohamed, Badreldin A.; Siddiqui, Adel Zia; Khan, Aftab Ahmed; Divakar, Darshan Devang

doi:10.1016/j.pdpdt.2019.101610

Cited by 26 publications

(53 citation statements)

References 35 publications

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“…Wang et al [ 54 ] found a decrease of IL-6 in the serum of rats after the adjunctive administration of amoxicillin and metronidazole during nonsurgical periodontal therapy. Al-Khureif et al [ 55 ] reported increased levels of IL-10 and reduced levels of lL-17 in the gingival crevicular fluid of periodontitis patients after subgingival instrumentation and adjunctive antibiotic therapy with amoxicillin and metronidazole. These studies did not include groups with just one of these combined used antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected—A Randomized Clinical Trial

2020

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Background: The aim was to compare two different systemic antibiotics regimens adjunctive to non-surgical periodontal therapy when Aggregatibacter actinomycetemcomitans was not detected in the subgingival biofilm. Methods: A total of 58 patients with periodontitis and with no A. actinomycetemcomitans in the subgingival biofilm were treated with full-mouth subgingival instrumentation and either metronidazole (MET; n = 29) or amoxicillin/metronidazole (AMX/MET; n = 29). Probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were recorded at baseline, as well as after three and six months. Subgingival biofilm and gingival crevicular fluid were collected and analyzed for major periodontopathogens and biomarkers. Results: PD, CAL and BOP improved at 3 and 6 months (each p < 0.001 vs. baseline) with no difference between the groups. Sites with initial PD ≥ 6 mm also improved in both groups after 3 and 6 months (p < 0.001) with a higher reduction of PD in the AMX/MET group (p < 0.05). T. forsythia was lower in the AMX/MET group after 3 months (p < 0.05). MMP-8 and IL-1β were without significant changes and differences between the groups. Conclusion: When A. actinomycetemcomitans was not detected in the subgingival biofilm, the adjunctive systemic use of amoxicillin/metronidazole results in better clinical and microbiological outcomes of non-surgical periodontal therapy when the application of systemic antibiotics is scheduled.

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Section: Discussionmentioning

confidence: 99%

Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected—A Randomized Clinical Trial

2020

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“…Five randomized clinical trials (RCT) were included in this review. The studies were conducted in Saudi Arabia [18] in Brazil [19,20] and in Poland [21,22]. The number of participants varied between 17 and 35 individuals per study, with a minimum age of 26 and a maximum age of 57 years.…”

Section: General Characteristics Of the Included Studiesmentioning

confidence: 99%

“…One study was conducted with smoking patients [19] while in the other four studies, smoking was one of the exclusion criteria. Patients diagnosed with chronic periodontitis were included in two studies [19,20] while the other three studies included patients with aggressive periodontitis [18,21,22].…”

Section: General Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Patient follow-up in all included studies was between 3 and 6 months postoperatively. One study showed favorable results to aPDT in the analyzed parameters [18], two studies showed equivalent results between the test and control group [19,20] and two studies showed better clinical results in group that used systemic antibiotic therapy [21,22] (Table 1).…”

Section: General Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Thus, antimicrobial photodynamic therapy (aPDT) has become a promising adjunctive therapy to scaling and root planing (SRP) in the treatment of periodontitis. Experimental studies in animals [12,15] and clinical studies in humans [16,17] have shown significant improvements in periodontal clinical parameters compared conventional mechanical treatment, and some studies have compared the effects of systemic antibiotic therapy with aPDT in periodontal clinical treatment [18,19,20,21,22]. aPDT basically consists of three components: a light source, a chemical molecule known as a photosensitizer (PS) and the presence of oxygen [14].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis

Souza

Rocha

Toro

et al. 2020

Photodiagnosis and Photodynamic Therapy

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Background: Periodontitis is one of the most prevalent inflammatory diseases in humans. It is associated with the presence of bacteria and is mediated by the host's immune response This study represents a systematic review and meta-analysis trying to answer the following question: "What is the effect of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) compared to systemic antibiotic therapy with amoxicillin plus metronidazole (AMX+MTZ) on the non-surgical treatment of periodontitis?". Methods: Clinical studies comparing aPDT with systemic use of AMX / MTZ were searched until January of 2020 using the databases: PubMed / MEDLINE, SCOPUS, EMBASE, Cochrane Central, Web of Science and Scielo, as well manual searches in related journals. Periodontal clinical parameters such as probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were statistically analyzed. Results: Five randomized clinical studies (RCTs) were included within the eligibility criteria and served as a basis for qualitative and quantitative analyzes. All the studies reported an improvement in the clinical parameters with both therapies, although in a direct comparison, our analyzes did not find statistical differences that indicate the superiority of one supporting treatment in relation to the other. Conclusion: Although the limited number of RCTs and the great heterogeneity between them, it can conclude that aPDT presents similar clinical results compared to antibiotic therapy with AMX+MTZ as adjuvants in the non-surgical treatment of periodontitis.

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Effectiveness of photodynamic therapy adjunct to oral debridement in improving clinical, microbiological, and pain in necrotizing ulcerative gingivitis

Al‐Kheraif,

Javed,

Al‐Momani

et al. 2023

Journal of Biophotonics

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To evaluate the efficacy of photodynamic therapy (PDT) as adjunctive to oral debridement (OD) in the improvement of clinical, microbiological, and pain in patients with necrotizing ulcerative gingivitis (NUG). Patients with NUG were split into two groups: Group‐OD + PDT received PDT with OD, while Group‐OD underwent OD alone. Clinical inflammatory parameters including full mouth plaque scores (FMPS), full mouth bleeding scores (FMBS), and probing depth (PD) were assessed. Fusobacterium nucleatum and Prevotella intermedia were analyzed using the polymerase chain reaction technique. Pain examination was done using various pain scales. Group PDT + OD showed more reduction in FMPS, FMBS, and greater reduction in F. nucleatum and P. intermedia count compared to group OD at 12 weeks follow up (p < 0.01). Group PDT + OD showed significantly lower pain scores at 12 weeks (p < 0.05). PDT was more effective in improving clinical parameters, and reducing bacterial counts and pain in NUG patients than dental scaling alone.

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Repeated application of photodynamic and antibiotic therapy as an adjunct to root surface debridement in patients with grade C and stage III or IV aggressive periodontitis

Cited by 26 publications

References 35 publications

Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected—A Randomized Clinical Trial

Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected—A Randomized Clinical Trial

Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis

Effectiveness of photodynamic therapy adjunct to oral debridement in improving clinical, microbiological, and pain in necrotizing ulcerative gingivitis

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