Repeatability and Reproducibility of Subfoveal Choroidal Thickness in Normal Eyes of Japanese Using Different SD-OCT Devices

Yamashita, Toshifumi; Yamashita, Takehiro; Shirasawa, Makoto; Arimura, Noboru; Terasaki, Hiroto; Sakamoto, Taiji

doi:10.1167/iovs.11-8836

Cited by 147 publications

(108 citation statements)

References 27 publications

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“…Mean value ± standard deviation was -3.87±22.06µm, higher than the value previously reported by Rahman et al 31 but of the same order of magnitude. subfoveal choroidal thickness was the only comparable value, owing to the different methods used to acquire images.Yamashita et al 32 reported nasal, subfoveal and temporal ICC values of 0.978, 0.976 and 0.904, respectively, similar to our results. The authors calculated subfoveal and temporal COVs of 23%, with a nasal value of 27%.…”

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confidence: 91%

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Choroidal Thickness and Volume in Healthy Young White Adults and the Relationships between them and Axial Length, Ammetropy and Sex

Sánchez‐Cano

Orduna

Segura

et al. 2014

American Journal of Ophthalmology

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PURPOSE:To evaluate choroidal thickness in young subjects using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography (EDI SD-OCT) describing volume differences between all the defined areas of the Early Treatment Diabetic Retinopathy Study (ETDRS). DESIGN:Prospective, clinical study. METHODS:Seventy-nine eyes of 95 healthy, young (23.8±3.2years), adult volunteers were prospectively enrolled. Manual choroidal segmentation on a 25-raster horizontal scan protocol was performed. The measurements of the nine subfields defined by the ETDRS were evaluated. RESULTS:Mean subfoveal choroidal thickness was 345.67±81.80µm and mean total choroidal volume was 8.99±1.88mm 3 . Choroidal thickness and volume were higher at the superior and temporal areas compared to inferior and nasal sectors of the same diameter respectively. Strong correlations between subfoveal choroidal thickness and axial length (AL) and myopic refractive error were obtained, r = -0.649, p<0.001 and r = 0.473, p<0.001 respectively. Emmetropic eyes tended to have thicker subfoveal choroidal thickness (381.94±79.88µm versus 307.04±64.91µm) and higher total choroidal volume than myopic eyes (9.80± 1.87mm3 versus 8.14±1.48mm3). The estimation of the variation of the subfoveal choroidal thickness with the AL was -43.84µm/mm. In the myopic group, the variation of the subfoveal choroidal thickness with the myopic refractive error was -10.45µm/D. CONCLUSIONS:This study establishes for the first time a normal database for choroidal thickness and volume in young adults. Axial length, and myopic ammetropy are highly associated with choroidal parameters in healthy subjects. EDI SD-OCT exhibited a high degree of intraobserver and interobserver repeatability. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT INTRODUCTIONThe development of optical coherence tomography (OCT) technology has revolutionized the diagnostic, monitoring and therapeutic approaches to many retinal diseases. Spectral domain OCT (SD-OCT) offers improved axial resolution (3 µm); by providing 19,000 A-scans per second, it shortens examination times, reducing the eye exposure as well as artifacts 1 . The latest development in OCT technology, sweptsource longer-wavelength OCT (SS-OCT), has a longer-band light source than does the conventional instrumentation (1 µm band light source), providing higher penetration through the retinal pigment epithelium (RPE) and allowing for better visualization of the choroid; however, at the present time, SS-OCT use is limited to research.The role of the choroid in a number of diseases, including central serous chorioretinopathy, high myopia, age-related macular degeneration, choroidal melanoma, and polypoidal choroidal vasculopathy, emphasizes the importance of understanding choroidal structure in ocular disease [2][3][4][5] . Indocyanine green has been the best tool for studying choroidal vasculature; however, it does not provide a quantitative evaluation of the layer; other imaging methods such as echography aid in evaluating the layer, and MRI ...

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supporting

confidence: 91%

“…Yamashita et al 32 reported nasal, subfoveal and temporal ICC values of 0.978, 0.976 and 0.904, respectively, similar to our results. The authors calculated subfoveal and temporal COVs of 23%, with a nasal value of 27%.…”

supporting

confidence: 91%

Choroidal Thickness and Volume in Healthy Young White Adults and the Relationships between them and Axial Length, Ammetropy and Sex

Sánchez‐Cano

Orduna

Segura

et al. 2014

American Journal of Ophthalmology

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“…Previous studies also showed that the measurements of choroidal thickness, using EDI-OCT, have good reproducibility and repeatability. 25,26 Besides, considering the similarity of the normal values of this study and that of the previous studies, measuring error may not be significant. 10,26,27 In conclusion, increased SFCT of patients with CSC was reduced after spontaneous resolution and lowfluence PDT.…”

Section: Discussionsupporting

confidence: 61%

Change in subfoveal choroidal thickness in central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy

Kang

2013

Eye

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Purpose To assess the change in subfoveal choroidal thickness (SFCT) in central serous chorioretinopathy (CSC) following spontaneous resolution and low-fluence photodynamic therapy (PDT) using the enhanced depth imaging optical coherence tomography (EDI-OCT). Methods A total of 36 consecutive eyes of 36 patients were included in this retrospective study: 16 eyes with spontaneously resolved CSC and 20 eyes with PDT-treated CSC. Best-corrected visual acuity and SFCT were evaluated at each visit until complete absorption of the subretinal fluid. SFCT of 32 normal subjects were also measured, as the control group. Wilcoxon's singed-rank test was used to evaluate the effects of spontaneous resolution and PDT. To compare the SFCT of the eyes with resolved CSC with that of the normal eyes, Mann-Whitney U-test with Bonferroni correction was also employed. Results SFCT of patients was 459.16 ± 77.50 lm at the baseline, and decreased to 419.31±54.49lm after a spontaneous resolution (P ¼ 0.015). However, SFCT was not normalized in comparison with that of the normal subjects (Po0.001). SFCT in PDT group was also reduced from 416.43 ± 74.01 to 349.50 ± 88.99 lm (Po0.001), with no significant difference with the normal value (P ¼ 0.087).Conclusions SFCT in patients with CSC decreased both after spontaneous resolution and low-fluence PDT. However, only in the PDT group, after disappearance of subretinal fluid, did it decrease to that of normal subjects.

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“…Previous studies excluded eyes with indistinct CSI or extrapolated the CSI. 18,19 Although exclusion of eyes with an indefinite boundary could result in higher repeatability, it might not reflect the practical aspects and cause selection bias. Hence, the current study adopted the extrapolation method, because the indistinct CSI should be considered a significant factor in measurement error.…”

Section: Discussionmentioning

confidence: 99%

“…Two previous investigations revealed high reliability and a strong correlation when comparing repeatability after scanning with three different SD-OCT devices. 18,19 Yamashita et al, 18 however, only considered eyes for which a distinct choroid boundary was seen by both observers, and Branchini et al 19 also averaged the measurements of two observers. Consequently, their studies had a greater tendency to overestimate repeatability than ours.…”

Section: Eyementioning

confidence: 99%

Influence of choroidal thickness on subfoveal choroidal thickness measurement repeatability using enhanced depth imaging optical coherence tomography

Cho

Choi

Kim

2014

Eye

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Repeatability and Reproducibility of Subfoveal Choroidal Thickness in Normal Eyes of Japanese Using Different SD-OCT Devices

Abstract: SCT measurements obtained with three different SD-OCTs were highly correlated and could be used interchangeably. (http://upload.umin.ac.jp number, UMIN000005287.).

Cited by 147 publications

References 27 publications

Choroidal Thickness and Volume in Healthy Young White Adults and the Relationships between them and Axial Length, Ammetropy and Sex

Choroidal Thickness and Volume in Healthy Young White Adults and the Relationships between them and Axial Length, Ammetropy and Sex

Change in subfoveal choroidal thickness in central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy

Influence of choroidal thickness on subfoveal choroidal thickness measurement repeatability using enhanced depth imaging optical coherence tomography

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