Repeatability and inter‐observer variation of choroidal thickness measurements using swept‐source optical coherence tomography in myopic danish children aged 6–14 years

Abstract

Purpose: To estimate repeatability and inter-observer variation of choroidal thickness measurements in myopic Danish children aged 7-14 years using sweptsource optical coherence tomography (SS-OCT). Methods: Thirty-nine children were enrolled. Optical correction was single-vision spectacles (SVS) or orthokeratology lenses (OKL). Three repeated 7 3 7 mm 3dimensional SS-OCT macula scans and three repeated 9 mm SS-OCT line scans were collected for each child using a DRI OCT Triton. Choroidal thickness was measured using three different methods: line scan method 1 (LM1), line scan method 2 (LM2) and 3D macula scan method (3DM). Segmentation was adjusted if needed. Coefficients of repeatability (CR) and limits of agreement (LoA) were calculated. Results: The CRs ranged from 13.4 to 23.9 µm, 14.5 to 26.2 µm and 5.2 to 10.7 µmfor LM1, LM2 and 3DM, respectively. The LoA ranged from À22.9 to +31.5 µm, À23.3 to +32.2 µm and À10.2 to +12.4 µm for LM1, LM2 and 3DM, respectively. Segmentation was adjusted in most scans (63%-92%). Mean choroidal thickness ranged from 142.2 AE 47.2 to 253.8 AE 60.9 µm and 190.1 AE 64.0 to 299.0 AE 55.8 µm for the SVS and OKL groups, respectively, measured by 3DM. Conclusion:The 3DM was the most repeatable method in this paediatric population. It yielded a CR of 10.7 µm, confidence interval 2.4 µm, which makes the minimal detectable difference between two measurements 13.1 µm. Most inter-observer variation could be explained by the intramethod variation. Segmentation adjustment on 3D macula scans did not increase CR on a group level.

Macular choroidal thickness and correlations in a healthy pediatric South Asian cohort: A spectral domain optical coherence tomography study

“…Normal biological changes are another possible source of error, for example, diurnal and pulsatile variations, hemodynamic choroidal changes associated with autonomic nervous system activity, and hormonal changes. Automated solutions have been suggested to lessen the inaccuracy of subjective disparities present in the procedures [40, 41].…”

“…Normal biological changes are another possible source of error, for example, diurnal and pulsatile variations, hemodynamic choroidal changes associated with autonomic nervous system activity, and hormonal changes. Automated solutions have been suggested to lessen the inaccuracy of subjective disparities present in the procedures [40,41]. The importance of measurement of ChT has been emphasized in the study of chorioretinal diseases, where choroidal dysfunction plays an important role in their pathogenesis, namely central serous retinopathy, polypoidal choroidal vasculopathy, age-related macular degeneration, retinal vascular diseases, retinitis pigmentosa, glaucoma, and uveitis [42][43][44].…”

Short‐term effects of cyclopentolate and tropicamide eye drops on macular choroidal thickness in myopic children

“…A significant strength of the study was the use of automatic segmentation to segment choroidal layers, which eliminated potential error in judgements during manual segmentation and provided correction for transverse magnification error. Recent advances in SS‐OCT segmentation algorithm software have improved automatic choroidal segmentations and allowed for more repeatable ChT measurements 43 . Only 16% of study participants required manual segmentation correction.…”

“…Recent advances in SS-OCT segmentation algorithm software have improved automatic choroidal segmentations and allowed for more repeatable ChT measurements. 43 Only 16% of study participants required manual segmentation correction.…”

Orthokeratology with increased compression factor in adolescent myopia control: a 2-year prospective randomized clinical trial

“…Chen et al [12] tried to alter the HOAs profile by modifying the lens design, but to date, no research has examined the effect of HOAs on the changes in axial length (AL) systematically. Changes in choroidal thickness after wearing ortho-k remain controversial [13] . However, some of these studies did not consider the diurnal variation, age, and spherical equivalent (SE), which could affect choroidal thickness [14] .…”