Repair of meniscal cartilage white zone tears using a stem cell/collagen-scaffold implant

Pabbruwe, Moreica; Kafienah, Wáel; Tarlton, John F; Mistry, Sanjay; Fox, Dennis J; Hollander, Anthony P.

doi:10.1016/j.biomaterials.2009.12.023

Cited by 117 publications

(106 citation statements)

References 27 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Xu et al studied collagen type-I scaffolds integrating bone sialoprotein for their capacity to induce osteoblast differentiation, and found that this treatment resulted in early mineral deposition by proliferating repair-cells in calvarial defects. Pabburke et al implanted collagen-based constructs seeded with MSCs in sheep meniscal disks, and confirmed by histomorphometric analysis that they improve integration compared to the scaffolds alone and the control (Pabbruwe et al, 2009;Pabbruwe et al, 2010). Zhou et al showed that substructurereinforced collagen matrixes seeded with chondrocytes supported neocartilage formation .…”

Section: Collagenmentioning

confidence: 97%

“…These results highlight, once again, the importance of providing the cells with scaffold compositions that mimic their natural environment. To enhance their regenerative properties even further, collagen scaffolds can be loaded with GFs such as BMPs (Laflamme & Rouabhia, 2008), TGF (Pabbruwe et al, 2010) and FGF (Pang et al, 2010). Collagen-based sponge constructs be impregnated in BMP-2 are already available as a FDA-approved commercial product for spinal reconstruction (Infuse TM , Medtronic, Inc.).…”

Section: Collagenmentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Scaffolds for the Controlled Formation of Complex Skeletal Tissues

Hofmann

García-Fuentes²

2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

View full text Add to dashboard Cite

Section: Collagenmentioning

confidence: 97%

Section: Collagenmentioning

confidence: 99%

Bioactive Scaffolds for the Controlled Formation of Complex Skeletal Tissues

Hofmann

García-Fuentes²

2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

View full text Add to dashboard Cite

“…Growth factors may not be the solution in all cases however. Pabbruwe et al, (2010) reported that whilst the addition of TGF- to a stem cell/collagen scaffold encouraged the appropriate differentiation of stem cells, it rendered the construct less well integrated to the adjacent tissue. The introduction of chemokines may be a further way of controlling/attracting an appropriate and effective population of cells to the location (Shen et al, 2014).…”

Section: Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus

Roberts¹,

Turner²,

Evans³

2016

Comprehensive Biotechnology

View full text Add to dashboard Cite

Synopsis/AbstractThe intervertebral disc in the spine and the meniscus in the knee are two fibrocartilaginous tissues which commonly are injured or become degenerate, causing significant clinical problems. The principals of tissue engineering, which are applicable elsewhere in the body, hold true for the disc and meniscus. Whilst there are some similarities with articular cartilage in terms of the molecules present, these fibrocartilages have their own peculiarities, some of which can be quite challenging. Following a description of the structure and anatomy of the disc and meniscus and the current clinical treatments, the different strategies for biological repair are described focusing particularly on cell therapy. The types of cells and scaffolds being investigated and how these can be modified are discussed.

show abstract

“…While these tissues have high biocompatibility, some of them cannot be employed for tissue engineering techniques as they do not allow varying structure geometry and initial mechanical properties . A more attractive strategy is represented by isolated tissue components as collagens and proteoglycans (Mueller et al, 1999;Pabbruwe et al, 2010). They maintain the high biocompatibility of the whole tissues while allowing to create custom-made scaffold with definite pore dimension and geometry and, consequently, biomechanical features.…”

Section: Scaffoldsmentioning

confidence: 99%

Meniscus repair and regeneration: review on current methods and research potential

Scotti

Hirschmann

Antinolfi

et al. 2013

eCM

126

123

View full text Add to dashboard Cite

Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cellfree scaffolds, gene therapy, intra-articular delivery of progenitor cells, biological glues for enhanced bonding of reparable tears, partial and total tissue engineered meniscus replacement. None of these approaches has been completely successful and can be considered suitable for all patients, as meniscal tears require specific and patientrelated treatments depending on the size and type of lesion. Recent advances in cell biology, biomaterial science and bioengineering (e.g., bioreactors) have now the potential to drive meniscus regeneration into a series of clinically relevant strategies. In this tutorial paper, the clinical need for meniscus regeneration strategies will be explained, and past and current experimental studies on meniscus regeneration will be reported.

show abstract

Repair of meniscal cartilage white zone tears using a stem cell/collagen-scaffold implant

Cited by 117 publications

References 27 publications

Bioactive Scaffolds for the Controlled Formation of Complex Skeletal Tissues

Bioactive Scaffolds for the Controlled Formation of Complex Skeletal Tissues

Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus

Meniscus repair and regeneration: review on current methods and research potential

Contact Info

Product

Resources

About