Renoprotective mechanisms of morin in cisplatin-induced kidney injury

Wei, Zhengkai; He, Xuexiu; Kou, Jinhua; Wang, Jingjing; Chen, Libin; Yao, Minjun; Zhou, Ershun; Fu, Yunhe; Guo, Changming; Yang, Zhengtao

doi:10.1016/j.intimp.2015.07.009

Cited by 41 publications

(29 citation statements)

References 25 publications

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“…Hesperidin or rutin administration ameliorated the cisplatin-induced nephrotoxicity as indicated by the restoration of kidney function and oxidative stress biomarkers. In different studies, Wei et al 14 suggested that morin may have renoprotective effects on cisplatin-induced kidney injury. Morin (3,2 0 ,4 0 ,5,7-pentahydroxyflavone) is one of the most common flavonols and it occurs in Morus alba L. and many other herbs and fruits.…”

Section: Introductionmentioning

confidence: 99%

Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity

Kaltalıoğlu

Cevher

2016

Renal Failure

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Oxidative stress is one of the important mechanisms of cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore the potential protective effects of morin and/or hesperidin on oxidative stress in cisplatin-induced nephrotoxicity. This study was performed on 42 Wistar rats. Rats were divided into seven groups: control, morin, hesperidin, cisplatin, cisplatin þ morin, cisplatin þ hesperidin, and cisplatin þ morin þ hesperidin. Morin and/or hesperidin were given for 10 consecutive days by oral gavage and on the 4th day a single dose of cisplatin (7 mg/kg) was injected intraperitoneally. After administrations, on the 11th day of the experiment the animals were killed, and malondialdehyde (MDA), nitric oxide (NOx), glutathione (GSH) levels and myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD) activity were measured. Cisplatin-treated rats showed increased levels of MDA, and decreased levels of NOx also activity of CAT. Morin and/or hesperidin pretreatment prevent oxidative stress in kidney tissue, while they increase the NOx level, CAT activity, and decrease MPO activity. In conclusion, morin þ hesperidin pretreatment may have a significant potential for protection of cisplatin-induced nephrotoxicity.ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity

Kaltalıoğlu

Cevher

2016

Renal Failure

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“…Antioxidant enzymes play critical roles in free radicals elimination [21]. For example, the decreased activity of GSH-px and SOD was significantly restored by morin [22] in CDDP treated mice, resulting in decreased free radical content. CDDP treatment causes a decrease in antioxidant enzyme activity in kidneys, likely from the loss of copper and zinc or by directly binding to sulfhydryl groups on cysteine.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Sika Deer Antler Protein on Cisplatin-Induced Nephrotoxicity

Yang

Wang³

et al. 2017

Cell Physiol Biochem

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Background/Aims: This study measured the effect of Sika deer (Cervus nippon Temminck) antler protein (SDAPR), glycoproteins (SDAG), and polysaccharides (SDAPO) on cisplatin-induced cytotoxicity in HEK 293 cells, and investigated the effect of SDAPR against cisplatin-induced nephrotoxicity in mice. Methods: Cell viability was measured by MTT assay. ICR mice were randomly divided into five groups: control, cisplatin with vehicle, and cisplatin with SDAPR at three concentrations: 5, 10, or 20 mg/kg, p.o., 10 d. Cisplatin was injected on 7^th day (25 mg/kg, i.p.). Renal function, oxidative stress, levels of inflammatory factors, and expression of apoptosis-related proteins were measured in vivo. Renal tissues were stained with TUNEL and H&E to observe renal cell apoptosis and pathological changes. Results: Pretreatment with SDAPR (125-2000 µg/mL) significantly improved cell viability, with an EC₅₀ of approximately 1000 µg/mL. SDAPR also ameliorated cisplatin-induced histopatholo- gic changes, and decreased blood urea nitrogen (BUN) and creatinine (Cr) (P < 0.05). Western blotting analysis showed SDAPR clearly decreased expression levels of cleaved-caspase-3 and Bax, and increased the expression level of Bcl-2 (P < 0.01). Additionally, SDAPR markedly regulated oxidative stress markers and inflammatory cytokines (P<0.05). TUNEL staining showed decreased apoptosis after SDAPR treatment (P < 0.01). Conclusions: These results indicate that SDAPR can be an effective dietary supplement, to relieve cisplatin-induced nephrotoxicity by improved antioxidase activity, suppressed inflammation, and inhibited apoptosis in vivo.

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“…A previous study showed that morin inhibited LPS-induced inflammatory mediator production in BV2 microglial cells [17]. Morin also has protective effects against cisplatininduced kidney injury in mice [18]. In addition, morin has been reported to inhibit IL-1β-induced inflammatory mediator production in human chondrocytes [19].…”

Section: Introductionmentioning

confidence: 96%

Morin Exhibits Anti-Inflammatory Effects on IL-1β-Stimulated Human Osteoarthritis Chondrocytes by Activating the Nrf2 Signaling Pathway

Wang

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Osteoarthritis (OA) is a multifactorial disease that is associated with inflammation in joints. The purpose of the present study was to investigate the anti-inflammatory activity and mechanism of morin on human osteoarthritis chondrocytes stimulated by IL-1β. Methods: The levels of NO and PGE2 were measured by the Griess method and ELISA. The levels of MMP1, MMP3, and MMP13 were also measured by ELISA. Results: The results revealed that IL-1β significantly increased the production of NO, PGE2, MMP1, MMP3, and MMP13. Additionally, the increases were significantly attenuated by treatment with morin. Furthermore, IL-1β-induced NF-κB activation was suppressed by morin. In addition, the expression of Nrf2 and HO-1 were increased by morin and knockdown of Nrf2 could prevent the anti-inflammatory effects of morin. Conclusion: In conclusion, this study suggested that morin attenuated IL-1β-induced inflammation by activating the Nrf2 signaling pathway.

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Renoprotective mechanisms of morin in cisplatin-induced kidney injury

Cited by 41 publications

References 25 publications

Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity

Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity

The Protective Effects of Sika Deer Antler Protein on Cisplatin-Induced Nephrotoxicity

Morin Exhibits Anti-Inflammatory Effects on IL-1β-Stimulated Human Osteoarthritis Chondrocytes by Activating the Nrf2 Signaling Pathway

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