Renal Venous Thrombosis in Neonates

Abstract

Five neonates with renal venous thrombosis (RVT) were studied at the onset of the disease, and four have been followed up for from 24 to 32 months after the time of diagnosis. Reduced glomerular filtration (two of four cases) on follow-up occurred only in infants with bilateral abnormalities as shown by results of physical examination, urography, renal scan, and angiography. Results of contrast studies showed the similarity between resolved RVT and certain congenital renal abnormalities. Renal tubular defects (polyuria, acidosis, hyperkalemia) constituted the primary clinical abnormalities in one of the two infants with renal insufficiency. Although the prognosis of RVT after medical management has improved, the ultimate outcome is unknown; the possibility of unsuspected neonatal RVT should be considered during investigation of children with unilaterally or bilaterally small kidneys.

Renal vein thrombosis in newborn infants

“…Ainda em relação à função renal evolutiva alguns autores concluíram não haver correlação entre as anormalidades demonstradas em estudos por imagem ou radioisó-topos e dados laboratoriais da função renal, ou seja, apesar das alterações morfológicas persistentes nos exames por imagem, a função renal estava normal, tanto pela medida do clearance da creatinina, quanto pela medida da capacidade de concentração urinária 5,12,18 . É possível, portanto, que tais anormalidades também observadas nos exames com DMSA em 2 pacientes deste estudo, que têm clearance de creatinina normal, sejam transitórias e compensadas por hipertrofia contralateral, que pode ocorrer nesta idade.…”

Early neonatal renal venous thrombosis: long‐term outcome

“…In the late neonatal period and in infancy, most cases of RVT are attributed to hyperosmolar states due to diarrhea and dehydration (1)(2)(3). The degree of recovery of the affected kidneys after acute thrombosis varies from full recovery to a wide spectrum of abnormal renal function, such as the non-functional contracted kidney, chronic renal failure, renovascular hypertension and renal tubular dysfunction (4)(5)(6)(7)(8)(9)(10). This study presents our experience in the management and long-term follow-up of six infants who presented with RVT in the early neonatal period.…”