2018
DOI: 10.1111/nep.13256
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Abstract: Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. … Show more

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Cited by 22 publications
(19 citation statements)
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References 96 publications
(214 reference statements)
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“…Acute kidney injury (AKI) characterized by abrupt deterioration in kidney function and tubular cell death is associated with high morbidity and mortality 1 . It can be caused by multiple pathological conditions, such as ischemia-reperfusion (I/R), sepsis, trauma, and nephrotoxic agents, including drugs with therapeutic uses 2,3 .…”
Section: Introductionmentioning
confidence: 99%
“…Acute kidney injury (AKI) characterized by abrupt deterioration in kidney function and tubular cell death is associated with high morbidity and mortality 1 . It can be caused by multiple pathological conditions, such as ischemia-reperfusion (I/R), sepsis, trauma, and nephrotoxic agents, including drugs with therapeutic uses 2,3 .…”
Section: Introductionmentioning
confidence: 99%
“…The level of CIS in the kidney is the highest in the proximal tubule (28). Proximal tubular cell injury and death are responsible for CIS-induced AKI (29), and proximal tubular cell death is associated with high morbidity and mortality (30). Therefore, in order to relieve kidney injury of patients with AKI and investigate the protective effect of FOR on cIS-induced AKI, the present study examined kidney and proximal tubular cells under cIS condition.…”
Section: Discussionmentioning
confidence: 99%
“…C5a, in addition to C3a, is an important anaphylactic and chemotactic factor involved in apoptosis and inflammation [22,23]. There are several ways to suppress the immune response, including corticosteroid treatments and several types of chemotherapies [24]. However, extensive suppression of the immune system can be hazardous since it exposes the patients to higher risks of sepsis.…”
Section: Discussionmentioning
confidence: 99%
“…However, extensive suppression of the immune system can be hazardous since it exposes the patients to higher risks of sepsis. In addition, at least certain elements of the immune system play important roles in the needed regenerative processes [24]. Accordingly, new alternatives that target specific elements of the immune system are being investigated.…”
Section: Discussionmentioning
confidence: 99%