Renal protective effect of sodium ferulate on pulmonary hypertension patients undergoing computed tomography pulmonary angiography

Zhao, Ying; Wang, Haiyan; Zhao, Jiayu; Wang, Xun; Wang, Yanbo; Li, Wei; Song, Tingting; Hao, Guiyang; Fu, Xianghua; Gu, Xing

doi:10.1177/2045894020903953

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…As one of the major components of Rhodiola algida, which prevents high latitude sickness clinically, FA is effective in hypoxia-induced pulmonary arterial hypertension animals [198]. Similarly, sodium ferulate has been used clinically in the treatment of pulmonary hypertension with satisfactory results [199].…”

Section: Other Pulmonary Diseasesmentioning

confidence: 99%

Ferulic Acid: A Review of Pharmacology, Toxicology, and Therapeutic Effects on Pulmonary Diseases

Zhai

Wang

et al. 2023

IJMS

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Ferulic acid (FA), a prevalent dietary phytochemical, has many pharmacological effects, including anti-oxidation and anti-inflammation effects, and has been widely used in the pharmaceutical, food, and cosmetics industries. Many studies have shown that FA can significantly downregulate the expression of reactive oxygen species and activate nuclear factor erythroid-2-related factor-2/heme oxygenase-1 signaling, exerting anti-oxidative effects. The anti-inflammatory effect of FA is mainly related to the p38 mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways. FA has demonstrated potential clinical applications in the treatment of pulmonary diseases. The transforming growth factor-β1/small mothers against decapentaplegic 3 signaling pathway can be blocked by FA, thereby alleviating pulmonary fibrosis. Moreover, in the context of asthma, the T helper cell 1/2 imbalance is restored by FA. Furthermore, FA ameliorates acute lung injury by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase pathways via toll-like receptor 4, consequently decreasing the expression of downstream inflammatory mediators. Additionally, there is a moderate neuraminidase inhibitory activity showing a tendency to reduce the interleukin-8 level in response to influenza virus infections. Although the application of FA has broad prospects, more preclinical mechanism-based research should be carried out to test these applications in clinical settings. This review not only covers the literature on the pharmacological effects and mechanisms of FA, but also discusses the therapeutic role and toxicology of FA in several pulmonary diseases.

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Section: Other Pulmonary Diseasesmentioning

confidence: 99%