Renal Metastasis of Malignant Melanoma with Unknown Primary

Shimko, Mark; Jacobs, Stephen C.; Phelan, Michael W.

doi:10.1016/j.urology.2006.11.013

Cited by 15 publications

(8 citation statements)

References 12 publications

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“…Malignant melanoma in the kidneys is usually located in the renal pelvis and in cases of metastatic lesions, multifocal metastasis is common 7. However, our patient did not exhibit a primary lesion and the tumor was located in the cortex.…”

Section: Discussionmentioning

confidence: 53%

Pigmented Perivascular Epithelioid Cell Tumor (PEComa) of the Kidney: A Case Report and Review of the Literature

et al. 2012

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Heavily pigmented perivascular epithelioid cell tumors (PEComa) are rare, only eight cases of which have been reported. Unlike typical epithelioid angiomyolipoma, most of these tumors have been encountered in female patients without tuberous sclerosis. The long-term prognosis thereof is undetermined. Cytological similarity and heavy melanin pigment make it difficult for pigmented PEComa to be differentiated from pigmented clear cell renal cell carcinoma or malignant melanoma. The immunoprofile of tumor cells, such as human melanoma black-45 expression, as well as the absence or presence of other melanocytic or epithelial markers, are helpful in determining a differential diagnosis. Here we report a case of heavily pigmented PEComa of the right kidney and review the literature describing this tumor. In this case, the immunoprofile and clinical features corresponded well to those described in the literature. Since the prognosis of such disease has not yet been established, close follow-up of this patient was recommended.

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Section: Discussionmentioning

confidence: 53%

Pigmented Perivascular Epithelioid Cell Tumor (PEComa) of the Kidney: A Case Report and Review of the Literature

et al. 2012

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“…Overt metastatic melanoma in the kidneys, on the other hand, is clinically uncommon. However, microscopic metastases of melanoma have been detected in up to 50% of patients [23]. This suggests that the local environment in the kidneys is not favorable for tumor growth and explain the infrequency of metastasis of most human cancers in the kidneys.…”

Section: Discussionmentioning

confidence: 99%

“…Given the minimal initial tumor cell death in the kidneys, it would indicate that the apparent lack of increased tumor cells is likely attributed to the adoption of dormancy phenotype, rather than an active proliferative status that is counter-balanced by active apoptotic events. Indeed, it has been reported that melanoma cells remained solitary with modest aggressiveness, even long after treatment [23,24]. The marked increase in growth at later stage may suggest remodeling and the activation of local stroma in the kidneys and lungs, boosting tumor cell growth.…”

Section: Discussionmentioning

confidence: 99%

Differential growth and responsiveness to cancer therapy of tumor cells in different environments

Alsaggar

Yao

Cai

et al. 2015

Clin Exp Metastasis

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Tumor metastasis often confers poor prognosis for cancer patients due to lack of comprehensive strategy in dealing with cells growing in different environment. Current anticancer therapies have incomplete effectiveness because they were designed assuming metastatic tumors behave similarly in different organs. We hypothesize that tumors growing in different sites are biologically heterogeneous in growth potential, as well as in tumor response to anti-cancer therapies. To test this hypothesis, we have developed a multi-organ tumor growth model using the hydrodynamic cell delivery method to establish simultaneous and quantifiable tumor growth in the liver, lungs and kidneys of mice. We demonstrated that growth rate of melanoma tumor in the liver is higher than that of the lungs and kidneys. Tumors in the lungs and kidneys grew minimally at the early stage and aggressively thereafter. Tumors in different organs were also heterogeneous in response to chemotherapy and immune gene therapy using dacarbazine and interferon beta gene, respectively. Lung tumors responded to chemotherapy better than tumors in the liver, but showed minimal response to interferon beta gene therapy, compared to tumors in the liver and kidneys. We also confirmed differential tumor growth of the metastatic colon cancer in mice. Our results point out the importance of a better understanding of the differences in tumor growing in diverse environments. The biological heterogeneity of metastatic tumors demonstrated in this study necessitates establishing new drug screening strategies that take into account the environmental difference at the sites of tumor growth.

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“…10 The most common primary sites for renal metastases (except hematologic malignancies) are lung, colon and breast carcinoma, melanoma and reproductive system malignancies. 10,11 Spread of metastasis to the kidney is usually hematogenous or lymphatic.…”

Section: • Metastasesmentioning

confidence: 99%

“…7). 11,12 The maximal and homogeneous parenchymal enhancement in this phase facilitates detection of renal metastases, which typically do not enhance to the same degree as the renal parenchyma. Renal metastases usually do not change the treatment approach due to the advanced stage of the disease.…”

Section: • Metastasesmentioning

confidence: 99%

The Renal Sinus—Transitional Cell Carcinoma and its Mimickers on Computed Tomography

Gayer

Zissin

2014

Seminars in Ultrasound, CT and MRI

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Renal Metastasis of Malignant Melanoma with Unknown Primary

Cited by 15 publications

References 12 publications

Pigmented Perivascular Epithelioid Cell Tumor (PEComa) of the Kidney: A Case Report and Review of the Literature

Pigmented Perivascular Epithelioid Cell Tumor (PEComa) of the Kidney: A Case Report and Review of the Literature

Differential growth and responsiveness to cancer therapy of tumor cells in different environments

The Renal Sinus—Transitional Cell Carcinoma and its Mimickers on Computed Tomography

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