Renal infarction in a patient with Coronavirus Disease 2019: another rare thrombotic event

Farias, Luís Arthur Brasil Gadelha; Cruz, Eberson de Alcântara; Silva, Angélica Maria Holanda Pascoal da; Almeida, Tássia Ívila Freitas de

doi:10.1590/0037-8682-0038-2021

Cited by 1 publication

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“…Two cases had orchitis while one case of epididymitis was reported previously (28). Renal infarction was documented in one case and has been described in adults with acute COVID-19 (29) but we could find no previous reports in MIS-C.…”

Section: Discussionmentioning

confidence: 63%

Multicenter cohort study of multisystem inflammatory syndrome in children (MIS-C)

Merckx

Cooke

Tal

et al. 2021

Preprint

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BACKGROUND: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We investigated risk factors for severe disease and explored changes in severity over time. METHODS: Children up to 17 years of age admitted March 1, 2020 through March 7th, 2021 to 15 hospitals in Canada, Iran and Costa Rica with confirmed or probable MIS-C were included. Descriptive analysis and comparison by diagnostic criteria, country, and admission date was performed. Adjusted absolute average risks (AR) and risk differences (RD) were estimated for characteristics associated with ICU admission or cardiac involvement. RESULTS: Of 232 cases (106 confirmed) with median age 5.8 years, 56% were male, and 22% had comorbidities. ICU admission occurred in 73 (31%) but none died. Median length of stay was 6 days (inter-quartile range 4-9). Children 6 to 12 years old had the highest AR for ICU admission (44%; 95% confidence interval [CI] 34-53). Initial ferritin greater than 500 mcg/L was associated with ICU admission. When comparing cases admitted up to October 31, 2020 to those admitted later, the AR for ICU admission increased from 25% (CI 17-33) to 37% (CI 29-46) and for cardiac involvement from 44% (CI 35-53) to 75% (CI 66-84). Risk estimates for ICU admission in the Canadian cohort demonstrated a higher risk in December 2020-March 2021 compared to March-May 2020 (RD 25%; 95%CI 7-44). INTERPRETATION: MIS-C occurred primarily in previously well children. Illness severity appeared to increase over time. Despite a high ICU admission incidence, most children were discharged within one week.

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Section: Discussionmentioning

confidence: 63%