2014
DOI: 10.1093/ndt/gfu250
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Abstract: These findings indicated that the severity of glomerular and interstitial lesions were significantly associated with renal outcomes in patients with DN, whereas the vascular indexes did not have any impact on renal outcomes.

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Cited by 176 publications
(147 citation statements)
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“…Worldwide, roughly 3% of newly diagnosed patients with Type 2 diabetes have overt nephropathy and about 20-30% of patients with Type 1 or Type 2 diabetes develop such complications throughout their life [54]. The early identification of DN is mandatory to delay ESKD, but early biomarkers (e.g.…”
Section: Discussionmentioning
confidence: 99%
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“…Worldwide, roughly 3% of newly diagnosed patients with Type 2 diabetes have overt nephropathy and about 20-30% of patients with Type 1 or Type 2 diabetes develop such complications throughout their life [54]. The early identification of DN is mandatory to delay ESKD, but early biomarkers (e.g.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, treatment approaches for DN and NDRD may diverge: for instance, IgA nephropathy, FSGS, membranous glomerulonephritis and other primary and secondary glomerular diseases usually benefit from personalized treatments (e.g. immunosuppressive therapies) rather than from general approaches [54]. The prognostic importance of RB is another aspect that should be seriously taken into consideration [2,10].…”
Section: Discussionmentioning
confidence: 99%
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“…Progressive renal structural and functional changes have been noted in diabetic patients [4-6]. The renal effects of diabetes include hemodynamic, morphological, and functional changes.…”
Section: Introductionmentioning
confidence: 99%
“…This finding is due to multiple factors affecting the concentration of serum creatinine, such as aging, race, and lifestyle. Currently, the National Kidney Disease Education Program (NKDEP) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), American Society of Nephrology (ASN), and National Kidney Foundation (NKF) recommend estimating GFR (eGFR) for serum creatinine in combination with age, sex, weight, or race to improve the accuracy of renal injury evaluation [6]. …”
Section: Introductionmentioning
confidence: 99%