Renal Function after Renal Ischemia in Dogs Infused with Atrial Natriuretic Peptide (ANP)

Dimitrov, D.; Klein, Hanns‐Georg; Atanasova, I; Thurau, Klaus; Natcheff, N

doi:10.1007/978-3-642-83858-3_21

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“…without lowering BP and with no effect on postischemic renal function [21]. In the pre sent study, the infusion rate of 100 ng/min x kgBW ANF resulted in plasma concentra tions of 552 ± 124 pg/ml without lowering BP below prcischemic values.…”

Section: Discussionmentioning

confidence: 97%

Atrial Natriuretic Factor Infusion following Acute Renal Ischemia in Anesthetized Dogs

Klein

Dimitrov²,

Atanasova³

et al. 1992

Kidney Blood Press Res

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Atrial natriuretic factor (ANF) has been shown to be effective in reversing renal functional impairments following renal ischemia. We studied the effects of a nonhypotensive intravenous ANF infusion (100ng/min × kg BW, 60 min) after 90 min unilateral renal arterial occlusion in anesthetized dogs with an intact contralateral kidney. ANF plasma levels remained unchanged in controls (group 1) and increased in ANF-infused animals (group 2) from 22 ± 3 to 552 ± 124 pg/ml. Blood pressure increased in both groups during renal ischemia, but returned to control values in group 2 when ANF infusion was started. Plasma vasopressin did not change in groupl, but increased in group 2 (0.77 ± 0.29 vs. 1.10 ± 0.49 pg/ml) after terminating ANF infusion. The postischemic fall in creatinine clearance (C_Cr) filtration fraction (FF) and renal blood flow (RBF) was prevented by infusion of ANF (C_cr: group 1, 0.16 ± 0.05 vs. group 2, 1.01 ± 0.25 ml/min × kg BW; FF: groupl, 4.0 ± 1.6 vs group2, 14.114.1%; RBF: groupl, 6.0 ± 1.2 vs. group 2,9.2 ± 1.6 ml/min × kg BW); however, the effects were limited to the time of infusion and the postischemic increase in urinary excretion of the proximal tubular enzyme N-acetyl-beta-D-glucosaminidase (NAG; group 1, 317.7 ± 163.6 vs. group 2, 672.4 ± 245.7 µU/min × kg BW) was not improved by ANF Our data suggest that infusion of ANF transiently reverses postischemic renal impairment. However, the failure to demonstrate a sustained postischemic improvement of renal functional parameters and to ameliorate massive NAG excretion casts doubt on the benefit of ANF infusion in preventing cellular damage.

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Section: Discussionmentioning

confidence: 97%