Renal Eicosanoids

Goppelt-Strbe, Margarete; Fauler, Joachim

doi:10.1002/9783527613625.ch7

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2001

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“…CYP4F2, CYP4F11 and CYPF12 are expressed in the kidney, and Northern blot analysis also suggests that expression of CYP4F11 and CYP4F12 occur in the heart (13,11). Renal eicosanoids have been implicated in renin release, regulation of blood flow and modulation of the actions of vasopressin (28). As many CYP4F enzymes metabolize arachidonic acid and eicosanoids, it will be of interest to determine the cellular localization of CYP4F enzymes in the intestinal mucosa and in the kidney, and to link their localization to biosynthesis and metabolism of eicosanoids or other biologically important lipid mediators.…”

Section: Discussionmentioning

confidence: 95%