Renal Changes in Patients with Hepatosplenic Schistosomiasis *

Andrade, Zilton A.; Andrade, Sônia Gumes; Sadigursky, Moysés

doi:10.4269/ajtmh.1971.20.77

Cited by 84 publications

(27 citation statements)

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“…Patients with chronic S. mansoni infection involving portal hypertension and an enlarged spleen (hepatosplenic schistosomiasis) have an increased frequency (15%) of renal disease; this infection is clinically characterized by variable proteinuria ranging from asymptomatic to nephrotic syndrome (4,10,61). The pathological changes vary.…”

Section: Schistosoma Mansonimentioning

confidence: 99%

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Glomerulopathy Associated with Parasitic Infections

Velthuysen¹,

Florquin²

2000

Clinical Microbiology Reviews

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Section: Schistosoma Mansonimentioning

confidence: 99%

“…Although schistosomiasis is one of the oldest and most widespread parasitic infections, its association with glomerular disease was established only in the 1970s (4,10). In some areas of endemic infection, more than 90% of adults are infected with schistosomes.…”

Section: Schistosomiasismentioning

confidence: 99%

Glomerulopathy Associated with Parasitic Infections

Velthuysen¹,

Florquin²

2000

Clinical Microbiology Reviews

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“…The pronounced hypergammaglobulinemia found in humans (16,26,106) and mice (251) and the occurrence of autoantibodies in the latter (134) (8,14). Proteinuria may be linked to HS disease manifestations (177,232).…”

Section: Introductionmentioning

confidence: 99%

Immunopathology of Schistosoma mansoni infection

1989

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Schistosomiasis mansoni is a chronic helminthic disease that affects about 100 million people in the tropics. The worms have a life span of 5 to 10 years, and they live in the mesenteric veins of the host. Lightly infected individuals are asymptomatic or manifest mild intestinal symptoms. Heavily infected individuals often develop severe morbidity with hepatosplenomegaly, sometimes with a fatal outcome. Morbidity is attributed to the strong humoral and T-cell-mediated host immune responses developed to a variety of parasite antigens and expressed as tissue inflammations. The immunopathology includes dermatitis, immune complex-mediated kidney disease, and, chiefly, T-cell-mediated granuloma formation and fibrosis around disseminated parasite eggs. This review describes the mechanisms of induction and expression of immunopathology in infected persons and experimental animals. Immunoregulatory mechanisms that modulate the enhanced immune responses and may ameliorate excessive morbidity are discussed.

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“…Studies in Brazil show that up to 15% of patients with hepatosplenic schistosomiasis also present renal disease [6][7][8][9][10][11][12][13][14] . In Egypt, Barsoum 15,16 reported that in 10% of patients on chronic hemodialysis, schistosomiasis was the primary cause of their renal failure.…”

Section: Introductionmentioning

confidence: 99%

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

Rodrigues

Otoni

Voieta

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction:The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. Methods: Sixty three patients (mean age 45.5±11 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosis of hepatosplenic schistosomiasis was based on epidemiological, clinical and parasitological data and imaging techniques. Eight patients, who presented >30mg/day albuminuria, were submitted to percutaneous ultrasound guided renal biopsy. Kidney tissue fragments were examined under light, direct immunofluorescence and electron microscopy. Results: All patients showed mesangial enlargement. In five, mesangial hypercellularity was observed and four presented duplication of the glomerular basement membrane. Areas of glomerular sclerosis were diagnosed in four. Deposits of immunoglobulin M and C3 were present in six samples; deposits of IgG in four, IgA in three and C1q in two samples. In all patients, immunoglobulin A was reported in the lumen of renal tubules. Deposits of kappa and lambda were observed in six samples. Electron microscopy revealed dense deposits in the glomerular tissue of three patients. Arterial hypertension, small esophageal varices, slight increases in serum creatinine and decreases in serum albumin were associated with glomerular disease. Conclusions: Renal disease associated with hepatosplenic schistosomiasis was verified in 12.7% of patients and type I membranoproliferative glomerulonephritis was observed in 50% of them. Schistosomal glomerulopathy still is an important problem in patients with hepatosplenic schistosomiasis in Brazil.

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Renal Changes in Patients with Hepatosplenic Schistosomiasis *

Cited by 84 publications

References 0 publications

Glomerulopathy Associated with Parasitic Infections

Glomerulopathy Associated with Parasitic Infections

Immunopathology of Schistosoma mansoni infection

Glomerulonephritis in schistosomiasis mansoni: a time to reappraise

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