Renal cell tumors with an entrapped papillary component: a collision with predilection for oncocytic tumors

CD117 Is a Specific Marker of Intraductal Papillary Mucinous Neoplasms (IPMN) of the Pancreas, Oncocytic Subtype

“…Our data clearly indicated that CD117 was expressed more frequently and with more diffuse/stronger staining patterns in IOPNs compared to the other IPMN subtypes [ 1 , 2 , 3 ]. This marker had been already described to be expressed in neoplasms composed of cells rich in mitochondria [ 1 , 24 , 25 , 26 ], and our findings confirmed this kind of association. Notably, CD117 did represent a potential additional tool to better distinguish IOPNs from the other IPMN subtypes.…”

“…Oncocytic tumors are rare and show a unique biological behavior [24]. They can develop in the thyroid, parathyroid and salivary glands, kidneys, and adrenal cortex, and are almost invariably characterized by an indolent neoplastic behavior regardless of the site [25,26]. IOPNs share similar characteristics as, even if malignancy evolution is remarkable, adjuvant therapies and surgery for disease recurrence ensure an excellent prognosis, different from other IPMN subtypes [27].…”

“…The aim of this study was to investigate the possible role of CD117 as a new potential biomarker supporting the diagnosis of IOPN, and to generate insights into the biology of this tumor entity. We focused our study on this marker since CD117 has been described as a potential useful immunohistochemical marker for oncocytic neoplasms of other districts, such as kidneys and thyroids [18][19][20][21][22][23][24][25][26]. CD117 is transmembrane protein functioning as a receptor tyrosine kinase [18,19].…”

True collision renal tumour of oncocytoma and papillary Renal cell carcinoma: Case Report and Review of the Literature

“…With no signs of metastases to the lungs (Figure 1 We describe a case of oncocytoma and papillary RCC. Our presentation is in line with previous reports that the possibility of mixed malignant tumours should be considered when treating benign renal tumours [2,[11][12][13][14][15][16][17][18][19].…”

“…With the exception of two cases [18,19] (Table 1), our patient was relatively younger (53-years old) compared to other cases [2,[11][12][13][14][15][16][17] (Table 1). Overall, the median age of men at diagnosis was 68 years, in accordance with reported median age of other renal tumours [21].…”