Renal cell carcinoma histological subtype distribution differs by age, gender, and tumor size in coastal Chinese patients

Abstract

The distribution pattern of renal cell carcinoma (RCC) histological subtypes according to age, gender and tumor size has not been well illustrated in RCC patients living in fast-developing regions of China. We recruited 2941 patients with clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (PCC) or chromophobe from two hospitals in coastal China (2004−2012) consecutively and draw 538 American Chinese RCC patients’ data with time matched from the Surveillance, Epidemiology, and End Results database. We found that compared with ccRCC patients, chromophobe patients were more likely to be female (OR: 2.538, 95% CI: 1.923−3.350), younger (OR for 51−60 years old: 0.686; OR for over 60 years old: 0.478; reference: age < 50) and to have a larger maximal diameter (Dmax) (OR for Dmax > 7 cm: 1.883; reference: Dmax ≤ 4 cm). Besides, in comparison with coastal Chinese patients, American Chinese individuals had lower Fuhrman grades (P < 0.001) and had an onset age 10 years delay. In conclusion, we were the first to observe marked gender, age and tumor size differences in the proportional subtype distribution of RCCs in coastal Chinese patients, and also the first to compare coastal Chinese with American Chinese data.

Decreased expression of METTL14 predicts poor prognosis and construction of a prognostic signature for clear cell renal cell carcinoma

“…Clear cell renal cell carcinoma (ccRCC), as the most common histological type of RCC, accounts for approximately 85% of all primary renal neoplasms [ 2 ]. The overall 5-year survival rate of RCC is 74% and 16% of patients have been diagnosed with local invasion or distant metastasis, resulting in a poorer prognosis [ 3 ]. Hence, the early diagnosis and treatment of ccRCC are imperative and challenging.…”

Nomograms for predicting long-term overall survival and disease-specific survival of patients with clear cell renal cell carcinoma

“…However, some researchers have reported that other clinicopathological factors such as race, sex, age, tumor size, and mode of presentation may also influence the RCC patients’ outcomes. 13 – 15 No single factor can account for the wide variability of outcomes observed in individual patients. Neglecting these significantly prognostic parameters may reduce the accuracy of survival predictions.…”

TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients&rsquo; survival

“… 3 Recently, 90.7% of RCC had been ccRCC, which was reported in a Chinese study. 4 Progression has been made to manage the patients for different diagnoses and treatments of ccRCC. Cancer metastasis and invasion lead to 90% of patient deaths, and ~30% of patients have been diagnosed with local invasion or distant metastasis, resulting in a poor prognosis.…”