2015
DOI: 10.18632/aging.100766
View full text | Cite
|
Sign up to set email alerts
|

Abstract: Global disruption of the GH receptor in mice (GHR−/−) produces a large and reproducible extension in lifespan. Since lack of GH action in muscle resulting in improved glucose homeostasis is potentially a mechanism by which GHR−/− mice are long-lived, and since no information on muscle-specific GHR disruption in females is available, we generated and characterized a line of muscle-specific GHR disrupted (MuGHRKO) mice. As expected, male MuGHRKO mice had improved fasting blood glucose, insulin, c-peptide, and gl… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
36
0

Year Published

2016
2016
2018
2018

Publication Types

Select...
2

Relationship

1
1

Authors

Journals

citations
Cited by 44 publications
(36 citation statements)
references
References 52 publications
(78 reference statements)
0
36
0
Order By: Relevance
“…This difference may be used to explain the differences between these two mouse lines. That is, the changes of growth, body compositions and insulin sensitivities were opposite in these two lines (304,305,306,307,308). Importantly, the MCK males increased maximum lifespan along with decreased inflammation (305,307,308) and they were protected from HF diet-induced metabolic deterioration(306).…”
Section: Muscle-specific Ghrkomentioning
confidence: 99%
“…This difference may be used to explain the differences between these two mouse lines. That is, the changes of growth, body compositions and insulin sensitivities were opposite in these two lines (304,305,306,307,308). Importantly, the MCK males increased maximum lifespan along with decreased inflammation (305,307,308) and they were protected from HF diet-induced metabolic deterioration(306).…”
Section: Muscle-specific Ghrkomentioning
confidence: 99%
“…In an effort to identify local and systemic effects of GH signaling in its various target organs, several laboratories generated mice with targeted deletion of the GH receptor in the liver, muscle, adipose tissue, pancreatic β-cells or macrophages [4350]. The resulting animals with organ specific GH resistance were phenotypically very different from the GHRKO mice.…”
Section: Selective Deletion Of the Gh Receptor In Different Gh Targetmentioning
confidence: 99%
“…To determine the role of different organs in mediating the striking effects of global GHR deletion on aging and longevity, the Kopchick laboratory produced new lines of mice with deletion of GHR limited to the adipose tissue, liver or skeletal and cardiac muscles [46, 47, 50]. Growth, body composition, glucose homeostasis and other phenotypic characteristics of animals from each of these lines were unique but none of them reproduced the phenotype of the animals with global GHR deletion (Table 1).…”
Section: Selective Deletion Of the Gh Receptor In Different Gh Targetmentioning
confidence: 99%
See 2 more Smart Citations