Remodeling of inherent antimicrobial nanofiber dressings with melamine-modified fibroin into neoskin

Hu, Weikang; Wang, Zijian; Xu, Yin; Wang, Xinghuan; Xiao, Yu; Zhang, Shengmin; Wang, Jianglin

doi:10.1039/c9tb00276f

Cited by 28 publications

(31 citation statements)

References 51 publications

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“…In contrast to SS, there are multiple studies that have used SF as a starting material for electrospun wound dressings. SF has been electrospun alone [ 127 , 130 , 140 , 142 , 143 ], in combination with synthetic polymers such as PCL [ 126 , 134 , 137 ], polyethylenimine (PEI) [ 129 ], PVA [ 131 , 132 ], poly(L-lactic acid-co-e-caprolactone) [ 136 ], PEO [ 135 , 137 , 138 , 144 , 145 ], and in combination with natural polymers such as gelatin [ 133 ] and CS as well as its derivatives [ 128 , 138 , 141 ] to tune the mechanical and physicochemical properties of the fiber mats ( Table 2 ). In many cases, the electrospun SF-based fibers have been post-treated with ethanol, methanol, acetone or glutaraldehyde to increase β-sheet crystallinity or cross-link the material to improve its water stability [ 130 , 132 , 135 , 140 , 142 , 143 ].…”

Section: Electrospinning Animal-derived Proteins For Wound Healingmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

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With the growth of the aging population worldwide, chronic wounds represent an increasing burden to healthcare systems. Wound healing is complex and not only affected by the patient’s physiological conditions, but also by bacterial infections and inflammation, which delay wound closure and re-epithelialization. In recent years, there has been a growing interest for electrospun polymeric wound dressings with fiber diameters in the nano- and micrometer range. Such wound dressings display a number of properties, which support and accelerate wound healing. For instance, they provide physical and mechanical protection, exhibit a high surface area, allow gas exchange, are cytocompatible and biodegradable, resemble the structure of the native extracellular matrix, and deliver antibacterial agents locally into the wound. This review paper gives an overview on cytocompatible and biodegradable fibrous wound dressings obtained by electrospinning proteins and peptides of animal and plant origin in recent years. Focus is placed on the requirements for the fabrication of such drug delivery systems by electrospinning as well as their wound healing properties and therapeutic potential. Moreover, the incorporation of antimicrobial agents into the fibers or their attachment onto the fiber surface as well as their antimicrobial activity are discussed.

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Section: Electrospinning Animal-derived Proteins For Wound Healingmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

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“…[ 45–46 ] The antimicrobial activities against Staphylococcus aureus and Escherichia coli were separately evaluated using the proliferation assay and colony forming unit (CFU) test. [ 47 ] The proliferation plots indicated the proliferation rates of bacterial remarkably declined along with the increase of deposition layers ( Figure b,e). Among them, the 7 layers group was obvious lower than that in the negative control group, indicating that QC in the 7 layers group could effectively inhibit the proliferation of E. coli and S. aureus .…”

Section: Resultsmentioning

confidence: 99%

High Flexible and Broad Antibacterial Nanodressing Induces Complete Skin Repair with Angiogenic and Follicle Regeneration

Wang

Zha

et al. 2020

Adv Healthcare Materials

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Complete skin reconstruction is a hierarchically physiological assembly involving epidermis, dermis, vasculature, innervation, hair follicles, and sweat glands. Despite various wound dressings having been developed for skin regeneration, few works refer to the complete skin regeneration, particularly lacking for vasculatures and hair follicles. Herein, an instructive wound dressing that integrates the antibacterial property of quaternized chitin and the mechanical strength and biological multifunction of silk fibroin through layer-by-layer electrostatic self-assembly is designed and reported. The resultant dressings exhibit a nanofibrous structure ranging from 471.5 ± 212.1 to 756.9 ± 241.8 nm, suitable flexibility with tensile strength up to 4.47 ± 0.29 MPa, and broad-spectrum antibacterial activity against Escherichia coli and Staphylococcus aureus. More interestingly, the current dressing system remarkably accelerates in vivo vascular reconstruction within 15 days, and the number of regenerated hair follicles reaches up to 22 ± 4 mm −2 , which is comparable to the normal tissue (27 ± 2 mm −2). Those crucial functions might originate from the combination between quaternized chitin and silk fibroin and the hierarchical structure of electrospun nanofiber. This work establishes an easy but effective pathway to design a multifunctional wound dressing for the complete skin regeneration.

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“…From a practical standpoint, we investigated the application of MHT derived CDs as filler in polymers via introducing them into electrospun nanofibers . Herein, we employed polycaprolactone (PCL), an FDA‐approved synthetic polymer as the scaffolds . After blending CDs and PCL in 2,2,2‐Trifluoroethanol (TFE), the solution was electrospun into nanofibers and collected on the surface of a grounded rotating drum to obtain nanofibrous scaffolds (Figure a).…”

Section: Figurementioning

confidence: 99%

Rapid and Large‐Scale Production of Multi‐Fluorescence Carbon Dots by a Magnetic Hyperthermia Method

et al. 2020

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The intrinsic low yield of carbon dots (CDs) is a barrier that limits practical application. Now, a magnetic hyperthermia (MHT) method is used to synthesize fluorescent CDs on a large scale (up to 85 g) in one hour (yield ca. 60 %). The reaction process is intensified by MHT since the efficient heating system enhances the energy transfer. CDs with blue, green, and yellow luminescence are synthesized by using carbamide and citrate with three different cations (Zn2+, Na+, K+), respectively. The CDs exhibit bright fluorescence under UV light and show excellent monodispersity and solubility in water. The alternation of photoluminescence (PL) emissions of these CDs is probably due to the difference in particle sizes and surface state. A bar coating technique is used to construct large‐area emissive polymer/CDs films. CDs can insert themselves into the polymer chains by hydrogen bonding and electrostatic interactions. Wound healing efficiency can be enhanced by the Zn‐CDs/PCL nanofibrous scaffold.

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Remodeling of inherent antimicrobial nanofiber dressings with melamine-modified fibroin into neoskin

Abstract: A melamine-modified fibroin was synthesized and fabricated into electrospun nanofiber films with broad-spectrum antimicrobial activity, sustained water retention, and fast reepithelialization and revascularization.

Cited by 28 publications

References 51 publications

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

High Flexible and Broad Antibacterial Nanodressing Induces Complete Skin Repair with Angiogenic and Follicle Regeneration

Rapid and Large‐Scale Production of Multi‐Fluorescence Carbon Dots by a Magnetic Hyperthermia Method

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