Remission and Relapse in Subjects with Panic Disorder and Panic with Agoraphobia

Keller, Martin B.; Yonkers, Kimberly A.; Warshaw, Meredith G.; Pratt, Lisa A.; Gollan, Jackie K.; Massion, Ann O.; White, K. Geoffrey; Swartz, Alan R.; Reich, James; Lavori, Philip W.

doi:10.1097/00005053-199405000-00007

Cited by 146 publications

(94 citation statements)

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“…In the Harvard Brown Anxiety Research Project (HARP) (42), the intensity of panic attacks and agoraphobia was graded on a rating scale from one to six where one indicated a symptom free state and six indicated daily panic attacks or extensive phobic avoidance. Full remittance of PD was defined as eight consecutive weeks of symptom ratings "one" or "two" for both panic and agoraphobia.…”

Section: Course Of Panic Disordermentioning

confidence: 99%

“…They reported a chronic course of PD with high risk of relapse after remission of PD symptoms (42). After 12 years, the probability of remission was 82% for patients with PD without agoraphobia and 48% for patients with PD with agoraphobia, but the probability of recurrence after a period of remission was more than 50% for both groups (43).…”

Section: Course Of Panic Disordermentioning

confidence: 99%

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A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

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Section: Course Of Panic Disordermentioning

confidence: 99%

Section: Course Of Panic Disordermentioning

confidence: 99%

A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

View full text Add to dashboard Cite

“…Panic disorder (PD) is a common psychiatric disorder with a lifetime prevalence of approximately 3% (Kessler et al, 1994), associated with high levels of social, occupational, physical disability (Klerman et al, 1991;Keller et al, 1994), and considerable economic costs (Leon et al, 1995). Numerous outcome studies have established the efficacy of pharmacological (Mavissakalian & Michelson, 1986) and psychological treatments (Barlow et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Feedback of end-tidal pCO2 as a therapeutic approach for panic disorder

Meuret¹,

Wilhelm²,

Ritz³

et al. 2008

Journal of Psychiatric Research

143

124

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Background-Given growing evidence that respiratory dysregulation is a central feature of panic disorder (PD) interventions for panic that specifically target respiratory functions could prove clinically useful and scientifically informative. We tested the effectiveness of a new, brief, capnometry-assisted breathing therapy (BRT) on clinical and respiratory measures in PD.Methods-Thirty-seven participants with PD with or without agoraphobia were randomly assigned to BRT or to a delayed-treatment control group. Clinical status, respiration rate, and end-tidal pCO 2 were assessed at baseline, posttreatment, 2-month and 12-month follow-up. Respiratory measures were also assessed during homework exercises using a portable capnometer as a feedback device.Results-Significant improvements (in PD severity, agoraphobic avoidance, anxiety sensitivity, disability, and respiratory measures) were seen in treated but not untreated patients, with moderate to large effect sizes. Improvements were maintained at follow-up. Treatment compliance was high for session attendance and homework exercises; dropouts were few.Conclusions-The data provide preliminary evidence that raising end-tidal pCO 2 by means of capnometry feedback is therapeutically beneficial for panic patients. Replication and extension will be needed to verify this new treatment's efficacy and determine its mechanisms.

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“…This reflects the basic fact that that a majority of the afflicted individuals are female. In an epidemiological sample the gender rate was 70% female vs. 30% male (Keller et al, 1994). In clinical samples an even larger proportion of female subjects has been identified.…”

Section: Gender Factorsmentioning

confidence: 93%

“…In a naturalistic one-year follow-up on 309 patients participating in the Harvard/Brown Anxiety Research Project (Keller et al, 1994), a 39% probability of full remission for uncomplicated PD was found. This is compared to a 17% probability of full remission for PDA.…”

Section: Clinical Coursementioning

confidence: 98%

Behavioral Treatments of Panic Disorder with Agoraphobia: Treatment Process and Determinants of Change

Ramnerö¹

2005

PsycEXTRA Dataset

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The present dissertation comprises four empirical studies within the area of behavioral treatment of panic disorder with agoraphobia. The focus is on studying issues pertaining to outcome, treatment process and determinants of change. The first study is a randomized controlled treatment study of 73 patients undergoing 16 sessions of either exposure in vivo (E), or cognitive behavior therapy (CBT). Both treatments showed clear improvements at post-treatment that were well maintained at 1-year follow up, and there were no significant differences between the treatments. The second study concerned prediction of outcome in the same sample. From a variety of pre-treatment characteristics severity of avoidance was the one most related to outcome. Most predictors were found unrelated. Two approaches of prediction were also compared: treating outcome as a categorical vs. continuous variable. The different approaches yielded a somewhat dissimilar picture of the impact of pre-treatment severity of avoidance. The third study examined different aspects of the therapeutic relationship, and their relation to outcome. Clients' perceptions of therapists and their ratings of the working alliance were generally not related to outcome at any point. On the other hand, therapists' perceptions of patients as showing goal-direction and active participation were related to outcome from early on in therapy. The fourth study examined different aspects of change. It was found that change in indices of the frequency of panic attacks was not closely related to change in agoraphobic avoidance at post-treatment. Change in avoidance was also more related to other aspects of outcome. At one-year follow-up, a more unitary picture, regarding the different aspects of change was observed.

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Remission and Relapse in Subjects with Panic Disorder and Panic with Agoraphobia

Cited by 146 publications

References 0 publications

A 1-year follow-up study of chest-pain patients with and without panic disorder

A 1-year follow-up study of chest-pain patients with and without panic disorder

Feedback of end-tidal pCO2 as a therapeutic approach for panic disorder

Behavioral Treatments of Panic Disorder with Agoraphobia: Treatment Process and Determinants of Change

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