Remifentanil Versus Fentanyl for Esophagogastroduodenoscopy in Children

Abstract

Remifentanil in combination with propofol provides good analgesic and sedative effects, which were shorter lasting compared with fentanyl-based sedation, and caused fewer delayed adverse effects. The use of remifentanil was associated with respiratory depression, emphasizing the need for experienced anesthesiologists.

The safety and efficacy of remifentanil compared to fentanyl in pediatric endoscopy

“…The reason for this low consumption could be the simultaneous administration of propofol and opioid together when additional doses were needed. Recovery times in our study were similar (8).…”

“…Opioids have been reported to reduce the need for propofol, in addition to providing hemodynamic stability and increasing the performance of the endoscopist by providing ease of procedure (2,(6)(7)(8)(9)(10). Different combinations of these agents were studied in pediatric anesthesia literature (2,8,10,11).…”

“…Different combinations of these agents were studied in pediatric anesthesia literature (2,8,10,11). Fentanyl is a frequently used opioid agent proven to be efficient and safe for pediatric procedures, but its potency is intermediate and blood clearance is slow, which usually leads to much longer anesthesia duration than that of endoscopic procedures (2,8,10,11).…”

“…Different combinations of these agents were studied in pediatric anesthesia literature (2,8,10,11). Fentanyl is a frequently used opioid agent proven to be efficient and safe for pediatric procedures, but its potency is intermediate and blood clearance is slow, which usually leads to much longer anesthesia duration than that of endoscopic procedures (2,8,10,11). Remifentanil, which is a more potent agent with shorter duration of action, is frequently used in pediatric outpatient anesthesia in bone marrow aspiration, bronchoscopy, and cardiac catheterization, as well as in laser photocoagulation in premature infants (12)(13)(14)(15).…”

Sedation monitoring during open muscle biopsy in children by Comfort Score and Bispectral Index – a prospective analysis

“…To perform a short intervention safely and effectively, various analgesic and sedative drug protocols have been used. In recent years propofol and remifentanil have been frequently applied in children . They are suitable for controlled sedation and can be safely employed in combination in children .…”