1999
DOI: 10.1046/j.1365-2559.1999.00667.x
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Abstract: Intraoperative frozen section analysis is a reliable procedure by which a high percentage of sentinel lymph node metastases can be detected in breast cancer patients without false positive results. This allows the surgeon to perform an immediate axillary lymph node dissection in case of positive SNs. In up to 10% of cases, the final paraffin sections will reveal micrometastases that were not detected by the frozen section, and in these patients axillary lymph node dissection will have to be performed in a seco… Show more

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Cited by 233 publications
(149 citation statements)
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“…These are nearby sections from the same ~2-mm node slabs, yet significant disagreements are seen where 1 set of slides contain metastatic tissue and the other set does not ( Table 7, Table 8 and Table 9). The lack of perfect agreement is caused by the analysis of different section samples from the same lymph node because significant metastases can be missed in nearby tissue left uncut on the block [13] and [14]. If site slide findings are compared with central slide findings as the reference, the agreement of the 2 histologic evaluations approximates the agreement between the BLN Assay and OHR on different ~2-mm node slabs.…”
Section: Resultsmentioning
confidence: 99%
“…These are nearby sections from the same ~2-mm node slabs, yet significant disagreements are seen where 1 set of slides contain metastatic tissue and the other set does not ( Table 7, Table 8 and Table 9). The lack of perfect agreement is caused by the analysis of different section samples from the same lymph node because significant metastases can be missed in nearby tissue left uncut on the block [13] and [14]. If site slide findings are compared with central slide findings as the reference, the agreement of the 2 histologic evaluations approximates the agreement between the BLN Assay and OHR on different ~2-mm node slabs.…”
Section: Resultsmentioning
confidence: 99%
“…The current recommendation when a sentinel lymph node is identified as positive is to perform a completion Level I and II axillary lymph node dissection, because additional lymph nodes will be involved in up to 40% of such patients. 23,24 Current practice dictates that, if the intraoperative assessment of the sentinel lymph node is positive, then a completion Level I and II axillary lymph node dissection is performed at the time of the initial operation. Unfortunately, the intraoperative examination of sentinel lymph nodes with frozen-section analysis, imprint cytology techniques, or both does not reveal all micrometastases.…”
Section: Clinical Dilemma: Predicting the Status Of The Axillary Sentmentioning
confidence: 99%
“…Routine frozen section examination of sentinel nodes has yielded more disappointing results, with sensitivities for the detection of cancer ranging from 44-87%. 39,40 Touch imprint cytology is one of the oldest techniques in cytology and is now being applied to the examination of lymph nodes. Immediately after excision, the node is bisected and the cut edge smeared over a glass slide, fixed and stained.…”
Section: Elastic Scattering Spectroscopymentioning
confidence: 99%
“…It is quick and easy to perform and gives similar results to frozen sections. [40][41][42] Both techniques, however, rely on the availability of a highly skilled pathologist, and it is likely that the excellent results reported from specialist units will not be replicated in smaller hospitals relying on a general pathologist for reporting. A real-time optical method for determining sentinel node involvement would provide significant benefits to patients undergoing surgery for breast cancer.…”
Section: Elastic Scattering Spectroscopymentioning
confidence: 99%