Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis
Daniel Spari,
Annina Schmid,
Daniel Sánchez-Taltavull
et al.
Abstract:Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to target inflammation. An important mediator of inflammation is extracellular adenosine triphosphate (ATP) that is released by inflamed host cells and tissues, and also by bacteria in a strain-specific and growth-dependent manner. Here, we investigated the mechanisms by which b… Show more
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