Release and toxicity of bisphenol-A (BPA) contained in orthodontic adhesives: A systematic review

Sabour, Anas; Helou, Marwan El; Roger-Leroi, Valérie; Bauer, Cynthia

doi:10.1016/j.ortho.2020.11.002

Cited by 14 publications

(8 citation statements)

References 38 publications

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“…Bisphenol A (BPA) is one of the monomers, which is widely known for its cytotoxicity and disruptive effect on endocrine [183]. It can also be detected in orthodontic adhesive [184]. However, it is controversial whether the amount of BPA in the saliva of orthodontic patients is sufficient to affect oral epithelial cells [184][185][186] since Invisalign plastic does not have the necessary ingredients to release bisphenol.…”

Section: Periodontal Response To Orthodontic Force Applicationmentioning

confidence: 99%

“…It can also be detected in orthodontic adhesive [184]. However, it is controversial whether the amount of BPA in the saliva of orthodontic patients is sufficient to affect oral epithelial cells [184][185][186] since Invisalign plastic does not have the necessary ingredients to release bisphenol. Eliades et al prepared eluent by immersing aligner for 2 months, and no estrogenic effects were detected [187].…”

Section: Periodontal Response To Orthodontic Force Applicationmentioning

confidence: 99%

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Immune System Acts on Orthodontic Tooth Movement: Cellular and Molecular Mechanisms

Gao

Min

et al. 2022

BioMed Research International

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Orthodontic tooth movement (OTM) is a tissue remodeling process based on orthodontic force loading. Compressed periodontal tissues have a complicated aseptic inflammatory cascade, which are considered the initial factor of alveolar bone remodeling. Since skeletal and immune systems shared a wide variety of molecules, osteoimmunology has been generally accepted as an interdisciplinary field to investigate their interactions. Unsurprisingly, OTM is considered a good mirror of osteoimmunology since it involves immune reaction and bone remolding. In fact, besides bone remodeling, OTM involves cementum resorption, soft tissue remodeling, orthodontic pain, and relapse, all correlated with immune cells and/or immunologically active substance. The aim of this paper is to review the interaction of immune system with orthodontic tooth movement, which helps gain insights into mechanisms of OTM and search novel method to short treatment period and control complications.

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Section: Periodontal Response To Orthodontic Force Applicationmentioning

confidence: 99%

Section: Periodontal Response To Orthodontic Force Applicationmentioning

confidence: 99%

Immune System Acts on Orthodontic Tooth Movement: Cellular and Molecular Mechanisms

Gao

Min

et al. 2022

BioMed Research International

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“…In addition to the harmful effects of BPA on various systems, such as the reproductive [ 20 ] or nervous systems [ 21 ], recent studies have suggested a correlation between BPA exposure and tumor development [ 22 ]. In vitro studies have shown that BPA stimulates the viability of breast cancer cells and increases oxidative stress [ 23 ]. Regarding the release of BPA from orthodontic appliances, it was observed that the maximum measured BPA release values, both in vitro and in vivo, were recorded in the first week after the implementation of the biomaterial [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…In vitro studies have shown that BPA stimulates the viability of breast cancer cells and increases oxidative stress [ 23 ]. Regarding the release of BPA from orthodontic appliances, it was observed that the maximum measured BPA release values, both in vitro and in vivo, were recorded in the first week after the implementation of the biomaterial [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Assessment of an Acrylic Removable Orthodontic Appliance Using 2D and 3D In Vitro Methods

et al. 2022

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Malocclusion is a global health problem, mainly affecting children and adolescents. For this reason, orthodontic treatment must be, on the one hand, safe, non-toxic, and effective and, on the other hand, it must have the best possible esthetic profile. Thus, the use of orthodontic appliances is addressed to all age groups, including young children, for a long period of time, which is why their safety profile is a matter of real interest. For this reason, the purpose of the present study was to evaluate the safety and biocompatibility of an acrylic removable orthodontic appliance made of polymethylmethacrylate and stainless steel alloy made by our team of researchers. To verify the biocompatibility of the medical device, it was immersed in artificial saliva with three different pHs (3, 7, and 10) for a period of ten days. Subsequently, the three types of saliva were tested on human keratinocytes (HaCaT cell line) in terms of viability and modification of cell morphology. Finally, the use of 3D reconstructed human epidermis verified the cytotoxic and irritating potential of the medical device, thus providing relevant information regarding its biocompatibility. The results revealed that by maintaining the orthodontic device in the saliva there is no release of substances with a toxic effect on the human keratinocytes and on the 3D reconstructed human epidermis. There were also no significant changes in cell morphology. In conclusion, it is suggested that the acrylic removable appliance has a safety profile recommended for in vivo use.

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“…Paralelamente, nas diferentes bases de dados atualmente encontram-se disponíveis 9 artigos de revisões integrativas e sistemáticas, os quais salientam os riscos e os efeitos biológicos maléficos do uso do BPA em Ortodontia (Eliades, 2007;Kloukos et al, 2013;Halimi et al, 2016;Eliades, 2017;Sifakakis e Eliades, 2017;Iliadi et al, 2020;Hassan et al, 2021;Lopes-Rocha et al, 2021;Sabour et al, 2021). Assim, o uso de adesivos ortodônticos compostos por Bis-GMA deve ser questionado, visto que são fontes derivadas do BPA, justificando a necessidade do desenvolvimento de materiais isentos deste composto, a fim de eliminar ou atenuar seus inconvenientes para a saúde humana.…”

Section: Introductionunclassified

Avaliação in vitro e in vivo de um sistema restaurador resinoso isento de Bisfenol-A, adaptado para uso na fixação de bráquetes ortodônticos

Delgado¹

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Agradeço primeiramente a Deus, grande professor do Universo, fonte infinita de bondade, misericórdia e amor, que me presenteia diariamente com saúde e perseverança, para conquistar novos objetivos sem esquecer de respeitar o meu semelhante.À minha mãe, Simone Mirian Rizental, por ser sempre referência e exemplo de vida. Lembro de na infância, acordar inúmeras vezes durante a madugada e ver você trabalhando horas a fio para me proporcionar a melhor educação possível.Obrigada por me ensinar a perseverar em todos os momentos da vida e encontrar propósito até diante das adversidades. Gratidão por você ter sido a minha primeira referência de educadora, por ser uma mãe zelosa e, por sua parceria e amizade sem condições. Te amo infinitamente! A toda a minha família e amigos queridos, por sempre vibrarem com muita alegria e se orgulharem a cada conquista minha. Ter vocês ao meu lado nessa caminhada faz a vida valer a pena! Amo vocês! Ao Prof. Dr. Paulo Nelson Filho, meu "pai científico", que acreditou no meu potencial antes mesmo de me conhecer. Ter a oportunidade de conviver com você foi como ganhar um tesouro. Você é luz em momentos de escuridão, guia sábio em etapas de decisão e ânimo quando a insegurança acontece. Obrigada por toda paciência e trato gentil e respeitoso. Me inspiro em você, para um dia, se possível, alçar vôos semelhantes aos seus! Sou eternamente grata por nossos caminhos terem se cruzado e pelas marcas permanentes que em mim você deixou. Foi uma honra ser sua orientada! Te levarei sempre comigo, como uma das mais importantes lembranças de minha vida e, farei questão de sempre que puder difundir ao mundo o quanto você é excelente! Todo aluno deveria ao menos uma vez na vida, ter um professor como você! Meus agradecimentos serão sempre pequeninos diante da grandiosidade dos seus ensinamentos. Obrigada por tanto! Ao Prof. Dr. Murilo Neupmann Feres, por toda a paciência e auxílio neste trabalho, além de sempre ter disponível uma palavra amiga e incentivo. Obrigada por trazer o domínio técnico-científico de alta qualidade, sempre atrelado a momentos de leveza e descontração, aos nossos dias de pesquisa clínica.À pós-doutoranda e amiga Ana Zilda Nazar Bergamo, por toda a parceria durante estes 4 anos de doutorado, além das valiosas sugestões para o aprimoramento deste trabalho. Sua delicadeza comigo se traduz em carinho, apoio e incentivo.Obrigada por toda a troca nestes anos e que venham muitos anos mais!

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Release and toxicity of bisphenol-A (BPA) contained in orthodontic adhesives: A systematic review

Cited by 14 publications

References 38 publications

Immune System Acts on Orthodontic Tooth Movement: Cellular and Molecular Mechanisms

Immune System Acts on Orthodontic Tooth Movement: Cellular and Molecular Mechanisms

Toxicological Assessment of an Acrylic Removable Orthodontic Appliance Using 2D and 3D In Vitro Methods

Avaliação in vitro e in vivo de um sistema restaurador resinoso isento de Bisfenol-A, adaptado para uso na fixação de bráquetes ortodônticos

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