Release and Activation of Matrix Metalloproteinase-9 During In Vitro Mechanical Compression in Hypertrophic Scars

The Inhibitory Effect of Minocycline on Hypertrophic Scarring

“…22,24 TIMP and collagen expression have also been shown to be up-regulated in hypertrophic scars, 1,25 further supporting this theory. Of indirect support is the observation that mechanical pressure induces hypertrophic scar fibroblasts to express more MMPs, 26 implying that a deficiency of MMP initiates the hypertrophy, and that pressure dressings work to prevent or to treat hypertrophic scars by correcting this deficiency.…”

“…1,[3][4][5][6][7][8][9][10][11][12][13][14][15][16] Pertinent to this study, the matrix metalloproteinase-tissue inhibitors axis has been shown to be deranged in hypertrophic scarring. 1,[17][18][19][20][21][22][23][24][25][26] This observation led us to investigate the effect of metalloproteinase inhibition on hypertrophic scarring. A variety of these inhibitors have been discovered and developed; among the best-characterized and most widely available is the antibiotic minocycline.…”

Skin tissue repair: Matrix microenvironmental influences

“…Proteases are found to persist in scar tissues. MMP-2 in particular, strangely in conjunction with its inhibitors TIMP-1 and TIMP-2, is found in human burn and hypertrophic scars (58), whereas MMP-9 appears to correlate with scar resolution (59). Other MMPs, particularly MMP-1 have been proposed as therapeutics to break down the fibrillar collagen to reduce scars.…”

Sehr hochfrequenter Ultraschall

“…Eine langfristig erhöhte Produktion von MMP-2 und MMP-9 sind bekannte Merkmale von chronischen Wunden [12], wobei besonders MMP-9 für eine verzö-gerte Wundheilung verantwortlich zu sein scheint [20]. Eine Suppression von MMP-2 und eine Stimulation von MMP-9 korrelieren wesentlich mit einer klinischen Verbesserung von hypertrophen Narben [21]. Dies könnte so interpretiert werden, dass MMP-2 eine "pro-narbenbildende" und MMP-9 eine "anti-narbenbildende" Wirkung zeigen.…”