Relaxivity control of magnetic nanoclusters for efficient magnetic relaxation switching assay

Cha, Jeongho; Kwon, Yong-Su; Yoon, Tae‐Jong; Lee, Jin-Kyu

doi:10.1039/c2cc36863c

Cited by 20 publications

(15 citation statements)

References 20 publications

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“…Significant values of r 2 (>500 mM −1 s −1 ) are obtained regardless of the size of the MNP used (from 6 to 16 nm), the type of organization, or the chemical route (CP, TD, polyol) adopted to prepare the magnetic nanoparticles. This observation clearly demonstrates the primacy of the total magnetic moment of assembly over the nanoparticle alone [20,26,30,31,36,38,39,41,49,74,75]. Optimal d H values are in a wide range between 70 and 250 nm depending on the systems considered.…”

Section: Namementioning

confidence: 77%

“…In MAR, the relaxivity is a function of d H 2 and increases with the outer sphere diameter assimilated to d H . In SDR, the relaxivity has reached a maximum and is independent of the outer sphere diameter [28,49]. Finally, when the d H increases too much, transverse relaxivity is described by ELR.…”

Section: Namementioning

confidence: 98%

“…According to the diameter d H of the contrast agent, three regimes are successively achieved ( Figure 3B): first the motional average regime (MAR), then the static dephasing regime (SDR) and finally the echo-limiting regime (ELR) [19,28,49,50]. Vuong et al [50] defined the transition from the MAR to SDR as a function of ∆ωτ D factor.…”

Section: Namementioning

confidence: 99%

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Luminophore and Magnetic Multicore Nanoassemblies for Dual-Mode MRI and Fluorescence Imaging

2019

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Nanoassemblies encompass a large variety of systems (organic, crystalline, amorphous and porous). The nanometric size enables these systems to interact with biological entities and cellular organelles of similar dimensions (proteins, cells, …). Over the past 20 years, the exploitation of their singular properties as contrast agents has led to the improvement of medical imaging. The use of nanoprobes also allows the combination of several active units within the same nanostructure, paving the way to multi-imaging. Thus, the nano-object provides various additional information which helps simplify the number of clinical procedures required. In this review, we are interested in the combination between fluorescent units and magnetic nanoparticles to perform dual-mode magnetic resonance imaging (MRI) and fluorescent imaging. The effect of magnetic interaction in multicore iron oxide nanoparticles on the MRI contrast agent properties is highlighted.

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Section: Namementioning

confidence: 77%

Section: Namementioning

confidence: 98%

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Luminophore and Magnetic Multicore Nanoassemblies for Dual-Mode MRI and Fluorescence Imaging

2019

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“…Therefore, the water protons were not in an inhomogeneous magnetic field, similar to free water molecules resulting in an increase in T 2 . This is known as static dephasing mode (SD mode) [33], with a corresponding increase in the T 2 of water [11,13]. The change in T 2 (ΔT 2 ) increased up to a plateau with increased Cd 2+ concentration (Fig.3).…”

Section: Au-fe 3 O 4 Nps As a Magnetic Sensor For CD 2+mentioning

confidence: 97%

A bifunctional sensor based on Au-Fe3O4 nanoparticle for the detection of Cd2+

Zhang

Zhao

Yang

et al. 2015

Sensors and Actuators B: Chemical

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“…Since DEVD can be recognized and cleaved by caspase‐3, the DEVD‐blended MCSPs were dissembled when using caspase‐3; this process could be detected with an increase in T 2 . Additionally, Yoon and Lee's group studied the change trend of T 2 when the as‐prepared MCSPs were assembled through the streptavidin‐biotin interaction 87. A series of PAA‐stabilized MCSPs were solvothermally synthesized and showed the controlled particle sizes from 15, 30 to 50 nm, which corresponded to an increase in r 2 from 247, 340 and 364 mM −1 s −1 , respectively.…”

Section: Biomedical Applications Of Mcspsmentioning

confidence: 99%

Magnetic Colloidal Supraparticles: Design, Fabrication and Biomedical Applications

2013

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Magnetic nanoparticles (MNPs) bear many intriguing properties such as superparamagnetism, high specific surface area, remarkable colloidal stability and biocompatibility, which evoke great interest and desire of exploration in biomedical applications. For the use in the complicated physiological environment, MNPs are still being developed to have the enhanced performances and down-to-earth practicality. Engineering of MNPs into hierarchical structures is thus proposed to create a new family of magnetic materials, magnetic colloidal supraparticles (MCSPs), which exhibit collective properties and unique nanomaterial characters. From a biomedical point of view, applicability of MCSPs is somewhat more distinctive in contrast to their primary MNPs, because MCSPs are amenable to modulation of secondary structure, promotion of magnetic responsiveness and ease of function design. As a result, MCSPs have been subject to intense researches in recent years, with the aim to develop outstanding composite materials for biomedical applications. In this review, we embark on an overview of foundational topics that detail the design and fabrication of MCSPs by evaporation-induced emulsion and solvothermal techniques, and continue with a guideline for modification of MCSPs with inorganic oxides and organic polymers. Particular focus is then placed on the biomedical applications of modified MCSPs. Many examples illustrate the latest progress in design of MCSP-based microspheres for magnetic resonance imaging, targeted drug delivery, sensing, and harvesting of peptides/proteins. After these detailed accounts, the current challenges and future development of researches and applications are discussed as a conclusion to the review.

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Relaxivity control of magnetic nanoclusters for efficient magnetic relaxation switching assay

Cited by 20 publications

References 20 publications

Luminophore and Magnetic Multicore Nanoassemblies for Dual-Mode MRI and Fluorescence Imaging

Luminophore and Magnetic Multicore Nanoassemblies for Dual-Mode MRI and Fluorescence Imaging

A bifunctional sensor based on Au-Fe3O4 nanoparticle for the detection of Cd2+

Magnetic Colloidal Supraparticles: Design, Fabrication and Biomedical Applications

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