Relative Advantages of Continuous Versus Batch Processes

Griffiths, JB

doi:10.1007/978-94-011-3550-4_48

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…A broad range of industries have adopted continuous processes, spanning chemical and oil refineries to food and life sciences ( 74 – 76 ). The reason for this implementation relates to the proven benefits continuous processing brings to reducing process cycle times, materials and energy used as well as waste production ( 77 ). Recently, the biopharmaceutical industry, with the rise of cell based therapies, had to become more competitive in terms of bioprocessing to reduce the costs of manufacturing ( 78 ).…”

Section: Continuous Cell Culture As An Alternative Approachmentioning

confidence: 99%

“…An alternative approach is to develop a new bioreactor that allows the continuous manufacture of adherent cells, based on the well-known benefits of continuous bioprocessing compared to batches ( Figure 7 ) ( 77 ). In order to do that, the critical steps are: (i) how to detach single-cells, (ii) how to maintain the system in equilibrium between detachment and proliferation (steady-state), and (iii) how to collect cells continuously.…”

Section: Continuous Cell Culture As An Alternative Approachmentioning

confidence: 99%

“…A broad range of industries have adopted continuous processes, spanning chemical and oil refineries to food and life sciences (74)(75)(76). The reason for this implementation relates to the proven benefits continuous processing brings to reducing process cycle times, materials and energy used as well as waste production (77).…”

Section: Continuous Cell Culture As An Alternative Approachmentioning

confidence: 99%

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Scale-Up Technologies for the Manufacture of Adherent Cells

Bellani

Ajeian²,

Duffy³

et al. 2020

Front. Nutr.

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Great importance is being given to the impact our food supply chain and consumers' food habits are having on the environment, human health, and animal welfare. One of the latest developments aiming at positively changing the food ecosystem is represented by cultured meat. This form of cellular agriculture has the objective to generate slaughter-free meat products starting from the cultivation of few cells harvested from the animal tissue of interest. As a consequence, a large number of cells has to be generated at a reasonable cost. Just to give an idea of the scale, there were billions of cells just in a bite of the first cultured-meat burger. Thus, one of the major challenges faced by the scientists involved in this new ambitious and fascinating field, is how to efficiently scale-up cell manufacture. Considering the great potential presented by cultured meat, audiences from different backgrounds are very interested in this topic and eager to be informed of the challenges and possible solutions in this area. In light of this, we will provide an overview of the main existing bioprocessing technologies used to scale-up adherent cells at a small and large scale. Thus, giving a brief technical description of these bioprocesses, with the main associated advantages and disadvantages. Moreover, we will introduce an alternative solution we believe has the potential to revolutionize the way adherent cells are grown, helping cultured meat become a reality.

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