Relationships of Sunlight, Complexion and Heredity to Skin Carcinogenesis

Hall, A. Fletcher

doi:10.1001/archderm.1950.01530110055004

Cited by 44 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic exposure to sunlight is thought to be an important predisposing factor for skin cancer among Caucasians and has been associated with premature aging of the skin (12). Sunscreens used for preventing sunburning during acute exposures to the sun also are advocated for the prevention of skin cancer recurrences and other chronic effects of solar irradiation (1,13).…”

Section: Discussionmentioning

confidence: 99%

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*

Matsuoka¹,

Ide²,

Wortsman³

et al. 1987

The Journal of Clinical Endocrinology & Metabolism

540

275

View full text Add to dashboard Cite

Sunscreens block the cutaneous absorption of UV-B radiation and prevent sunburning, premature aging, and cancer of the skin. Inasmuch as UV-B radiation is also responsible for the photosynthesis of vitamin D3, we investigated the effect of sunscreens on the cutaneous formation of vitamin D3 in vivo and in vitro. Eight normal subjects, four of whom had been protected with the sunscreen para-aminobenzoic acid (sun protection factor 8), were exposed to one minimal erythema dose of UV radiation. The mean serum vitamin D3 concentration increased from 1.5 +/- 1.0 (+/- SEM) to 25.6 +/- 6.7 ng/mL in unprotected subjects, whereas it was 5.6 +/- 3.0 and 4.4 +/- 2.4 ng/mL at these times in the subjects who were protected with para-aminobenzoic acid. Para-aminobenzoic acid also prevented the photoisomerization of 7-dehydrocholesterol to previtamin D3 in human skin slices in vitro. These results indicate that the sunscreen interferred with the cutaneous production of vitamin D3.

show abstract

Section: Discussionmentioning

confidence: 99%

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*

Matsuoka¹,

Ide²,

Wortsman³

et al. 1987

The Journal of Clinical Endocrinology & Metabolism

540

275

View full text Add to dashboard Cite

show abstract

“…Exposure to sunlight also results in a darkening of the skin which has been considered attractive in certain societies, particularly with the advent of the industrial revolution when much labor was moved indoors (Albert and Ostheimer, 2003a; Ibrahim and Brown, 2008). However, beginning in the 1900s, excessive sun exposure has been linked to skin cancer and by the second half of the century, there was overwhelming evidence implicating ultraviolet radiation (UVR) as a carcinogen (Ibrahim and Brown, 2008; Blum et al, 1941; Findlay, 1928; Hall, 1950; Levine et al., 2005). There have also been increased suggestions of purported benefits via vit D in regard to bone health and, more recently, reduced risk for internal malignancy (Giovannucci, 2005; Freedman et al, 2007; Skinner, 2008; Lu et al, 2008; Stolzenberg‐Solomon, 2008; Ahn et al, 2008; Khazai et al, 2008).…”

Section: Tanning Overviewmentioning

confidence: 99%

UV and pigmentation: molecular mechanisms and social controversies

Tran

Schulman

Fisher

2008

Pigment Cell Melanoma Res

View full text Add to dashboard Cite

SummaryUltraviolet radiation (UVR) is an essential risk factor for the development of premalignant skin lesions as well as of melanoma and non-melanoma skin cancer. UVR exerts many effects on the skin, including tanning, carcinogenesis, immunomodulation, and production of vitamin D. Vitamin D (vit D) is important in the maintenance of healthy bones as well as other purported beneficial effects, amongst which is the potential for reducing risk of malignancy-though oral supplementation is fully capable of maintaining systemic levels.The known medical harm from UV exposure relates primarily to cancer of the skin-the most common organ in man to be affected by cancer. In this review, we summarize the knowledge about the ultraviolet (UV) response in regards to inflammation, immunosuppression, carcinogenesis and the tanning response. We also discuss vit D and UV, as well as public health implications of tanning behavior and commercial interests related to the promotion of UV exposure. As the most ubiquitous human carcinogen, UVR exposure represents both a challenge and enormous opportunity in the realm of skin cancer prevention.

show abstract

“…Salsbury [8] has reported the very low rate of occurrence in Navajo Indians. Private practitioners have recorded their experiences in North Carolina [9] and Mississippi [10], while workers at the University of California [6] have given us the only detailed study of certain hereditary factors in this disease. The New England cases are covered by sampling supplied by Warren and his co-workers in Boston.…”

Section: Skin Cancer In United Statesmentioning

confidence: 99%

“…Usually, the population of the sunniest and hottest areas of the earth have relatively more pigment in their skins than people in the temperate zones, and clinical data support the claims that pigmented persons have less skin cancer than those of blond type. Medi-cal writings of Phillips [4,5] in Texas and Hall [6] in California have shown these facts in a striking way.…”

mentioning

confidence: 99%

Climate and Skin Cancer *

Phillips

1951

Bulletin of the American Meteorological Society

View full text Add to dashboard Cite

Relationships of Sunlight, Complexion and Heredity to Skin Carcinogenesis

Cited by 44 publications

References 19 publications

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*

UV and pigmentation: molecular mechanisms and social controversies

Climate and Skin Cancer *

Contact Info

Product

Resources

About

Relationships of Sunlight, Complexion and Heredity to Skin Carcinogenesis

Cited by 44 publications

References 19 publications

Sunscreens Suppress Cutaneous Vitamin D3Synthesis*

Sunscreens Suppress Cutaneous Vitamin D3Synthesis*

UV and pigmentation: molecular mechanisms and social controversies

Climate and Skin Cancer *

Contact Info

Product

Resources

About

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*

Sunscreens Suppress Cutaneous Vitamin D₃Synthesis*