Relationships Between the Changes of Serum Levels of OPG and RANKL with Age, Menopause, Bone Biochemical Markers and Bone Mineral Density in Chinese Women Aged 20-75

Liu, J. M.; Zhao, Hongyan; Ning, Guang; Zhao, Yongju; Chen, Y.; Zhang, L. Zh.; Sun, Lin; Xu, Man-yin; Chen, J. L.

doi:10.1007/s00223-004-0007-2

Cited by 70 publications

(58 citation statements)

References 35 publications

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“…Se ve ral stu di es has tri ed to re ve al its re la ti ons hip bet we en bo ne tur no ver mar kers and BMD. Pre vi ous re se arch ha ve in di ca ted that BMD is po si ti vely 60 or ne ga ti vely 22 re la ted or not re la ted [25][26][27]30,61 to serum OPG le vels. Pa ti ents with low BMD at so me cer ta in si tes ha ve de mons tra ted hig her OPG 62 and sRANKL le vels; [63][64][65] or ne ga ti ve cor re la ti ons bet ween se rum OPG and RANKL le vels with BMD.…”

Section: Opg-ranklmentioning

confidence: 99%

“…29 Ho we ver, Li u et al fo und an in ver se cor re la ti on bet we en se rum OC and se rum sRANKL and sRANKL/OPG ra ti os. 30 In this pre sent study, des pi te a sig ni fi cant re duc ti on in the per centa ge of sRANKL/OPG ra ti os in LIG and CG, we found that ne it her BMD at any ske le tal si te me a su red nor bo ne turn-over mar kers cor re la ted with sRANKL/OPG ra ti o. Sin ce we ob ser ved a sig ni ficant re duc ti on in sRANKL in all gro ups and sig nifi cant re duc ti ons in sRANKL/OPG ra ti os in LIG and CG wit ho ut any sig ni fi cant chan ge in HIG, we can in fer that this re duc ti on might not ha ve be en af fec ted by the re sis tan ce tra i ning pro to col.…”

Section: Opg-ranklmentioning

confidence: 99%

“…29 Similarly, Li u et al de mons tra ted no asso ci a ti on bet we en BMD and se rum sRANKL or sRANKL/OPG ra ti os, but they fo und an in ver se cor re la ti on bet we en se rum OC and se rum sRANKL and sRANKL/OPG ra ti os. 30 The la test sci en ti fic ad van ces ha ve enab led us to de tect cir cu la ting OPG and RANKL in pe rip heral blo od; ho we ver, it is still not cer ta in whet her cir cu la ting OPG and RANKL ref lect chan ges in bone me ta bo lism as a re sult of physi cal ac ti vity sin ce the re are very few stu di es with conf lic ting re sults in di ca ting the cor re la ti on bet we en the physi cal acti vity and the OPG/sRANKL system, 16,31 however the re are no stu di es exa mi ning the ef fects of re sistan ce tra i ning for 12 we eks on OPG/sRANKL system, with the ot her bo ne tur no ver mar kers and BMD of so me cer ta in si tes in post me no pa u sal women. The re fo re, the aim of the pre sent study was to il lu mi na te the chan ges in sRANKL and OPG-se rum le vels, as well as the ot her bo ne tur no ver mar kers and BMD of so me cer ta in si tes in post me no pa u sal wo men fol lo wing a 12-we ek high-ver sus low-inten sity re sis tan ce tra i ning.…”

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Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Karaarslan¹,

Büyükyazi²,

Taneli³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : To in ves ti ga te the ef fects of 12-we ek two-dif fe rent in ten sity re sis tan ce tra i ning prog rams on bo ne tur no ver mar kers, bo ne mi ne ral den sity (BMD), os te op ro to ge rin (OPG), and so lub le recep tor ac ti va tor of nuc le ar fac tor kap pa β li gand (sRANKL) in post me no pa u sal wo men. M Ma a t te e r ri i a al l a an nd d M Me et t --h ho od ds s: : Forty he althy wo men (aged 45-60 ye ars) par ti ci pa ted in the study. High-in ten sity gro up (HIG; n=14) wor ked 4 days a we ek and per for med two sets of 8-10 re pe ti ti ons at ~70-80% of 1 re pe at ma xi mum (RM). Low-in ten sity gro up (LIG; n= 13) wor ked in the sa me du ra ti on, with 13-17 re pe ti ti ons, at ~40-50% of 1RM. Con trol gro up (CG; n = 13) did not per form any exer ci ses. Body com po si ti on, 1RM va lu e for 10 exer ci ses, re pe ti ti ons of sit-ups for 30 se conds, bo ne for ma ti on and re sorp ti on mar kers, se rum os te o cal ci ne (OC), bone al ka li ne phosp ha ta se (BAP), βCross Labs, OPG, and sRANKL le vels we re me a su red be fo re and af ter the tra i ning prog ram. BMD was me a su red vi a du al energy X-ray ab sorp ti o metry. R Re e s su ul lt ts s: : Re sis tan ce tra i ning ca u sed in cre a ses in spi ne BMD in HIG and LIG (p< 0.05), and OC le vels in cre a sed in the HIG (p< 0.05). We ob ser ved a sig ni fi cant dif fe ren ce bet we en the per cent chan ge in HIG ver sus the per cent chan ge in CG in the spi ne BMD va lu es (p< 0.01). sRANKL le vels dec re a sed sig ni fi cantly in all three gro ups. Strength me asu res in cre a sed in both exer ci se gro ups (p< 0.001), fa vo ring the HIG. C Co on nc c l lu u s si i o on n: : High-in ten sity re sis tance tra i ning may be mo re ef fec ti ve for in cre a sing musc le strength and pro tec ting aga inst os te o po ro sis and frac tu res. Du e to in sig ni fi cant chan ges in OPG le vels and sig ni fi cant re duc ti ons in sRANKL in all gro ups, me a su res of cir cu la ting OPG and sRANKL le vels se em not to be so use ful to pre dict BMD or bo ne tur nover sta tus af ter re sis tan ce tra i ning prog rams. The re fo re, the se pa ra me ters re ma in to be de ter mi ned di rectly in the bo ne mic ro en vi ron ments to get her with BMD me a su res and bo ne tur no ver mar kers.K Ke ey y W Wo or rd ds s: : Os te o po ro sis, post me no pa u sal; RANK li gand; os te op ro te ge rin Ö ÖZ ZE ET T A Am ma aç ç: : İki fark lı yük len me şid de tin de ya pı lan 12 haf ta lık di renç an tren man prog ram la rı nın postme ne po zal dö nem de ki ka dın la rın, ke mik tur no ver mar ker le ri, ke mik mi ne ral yo ğun lu ğu (KMY), os te opro ge rin (OPG) ve so lub le nük le er fak tör kap pa Β re sep tör ak ti va tör li gan dı (sRANKL) üze ri ne olan et ki si ni be lir le mek. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Post-me no poz dö nem de ki 40 sağ lık lı ka dın (45-60 yaş) ça lış ma ya ka tıl -dı. Yük sek şid det gru bu (YŞG; n= 14) haf ta da 4 gün, 1 tek rar mak si mu mun (TM)...

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Section: Opg-ranklmentioning

confidence: 99%

Section: Opg-ranklmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Karaarslan¹,

Büyükyazi²,

Taneli³

et al. 2010

Turkiye Klinikleri J Med Sci

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“…However, some studies found no age-dependent change in the RANKL serum level in healthy individuals 54 or decreased in the serum RANKL concentration with age. 55 One explanation for this discrepancy may be that serum RANKL levels do not consistently reflect the local microenvironment in the bone. Besides bone, a variety of other extraskeletal tissues such as brain, heart, kidney, skeletal muscle, and skin can express RANKL mRNA, which highlights the importance of assessing RANKL levels directly in the bone's microenvironment.…”

Section: Gene Expression Analysis Of Major Lineage-defining Factors Imentioning

confidence: 99%

Gene expression analysis of major lineage‐defining factors in human bone marrow cells: Effect of aging, gender, and age‐related disorders

Jiang

Mishima

Sakai

et al. 2008

Journal Orthopaedic Research

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Adult bone marrow cells (BMCs) include two populations:;mesenchymal stem cells (MSCs), which can differentiate into bone, cartilage, and fat; and hematopoietic stem cells (HSCs), which produce all mature blood lineage. To study the effect of aging, gender, and agerelated disorders on lineage differentiation, we performed quantitative RT-PCR to examine mRNA expression of the major factors defining BMC lineage, cbfa1 for osteoblasts, ppar-gamma for adipocytes, sox9 for chondrocytes, and rankl for osteoclasts, in bone marrow from 80 healthy subjects and patients (14-79 years old) with two age-related disorders: osteoarthritis (OA) and rheumatoid arthritis (RA). Two apoptosis-related genes, bcl-2 and drak1, were studied. RANKL and PPAR-Gamma levels exhibited a clear positive correlation with age in female patients, but not in males, with a slight age-related decline in CBFa1 transcripts. DRAK1 expression showed an age-associated ascending trend with significantly greater transcripts of RANKL and DRAK1 in females ( p < 0.01). Compared with age-matched controls, RA patients exhibited increased RANKL, PPAR-Gamma, and DRAK1 mRNA levels (p < 0.05), and OA showed the higher RANKL and PPARGamma transcripts (p < 0.05). Furthermore, SOX9 and DRAK1 expressions in the RA group were higher than in the OA group (p < 0.05). Our data indicate that aging and age-related disorders affect gene expressions differently, suggesting that in aging, the lineage of bone marrow cells was modified with prominent changes in decreased bone marrow osteoblastogenesis, increased adipogenesis and osteoclastogenesis, while in age-related disorders, marrow adipogenesis and the activity or number of osteoclasts may play an important role in the pathogenesis of arthritic bone loss. ß

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“…OPG is a soluble receptor for RANKL and acts as a decoy receptor in the RANK-RANKL signalling system [16,17]. Some studies have shown that circulating osteoprotegerin and receptor activator of NF-kappa B ligand system are associated with bone metabolism [18,19]. It was also suggested that interleukins may play an important role for post-BMT bone loss in adults [20], possibly via the RANKL pathway [21].…”

Section: Introductionmentioning

confidence: 99%

The role of Insulin-like Growth Factor 1, Receptor Activator for Nuclear Factor κB ligand — Osteoprotegerin system, Interleukin 6 and 1β in post-transplantation bone metabolic disease in childhood

Wędrychowicz

Sztefko²,

Majka³

et al. 2013

Endokrynologia Polska

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Relationships Between the Changes of Serum Levels of OPG and RANKL with Age, Menopause, Bone Biochemical Markers and Bone Mineral Density in Chinese Women Aged 20-75

Cited by 70 publications

References 35 publications

Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Gene expression analysis of major lineage‐defining factors in human bone marrow cells: Effect of aging, gender, and age‐related disorders

The role of Insulin-like Growth Factor 1, Receptor Activator for Nuclear Factor κB ligand — Osteoprotegerin system, Interleukin 6 and 1β in post-transplantation bone metabolic disease in childhood

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