Relationships between steady state blood concentrations and cardiac output during intravenous infusions

The two-compartment recirculatory pharmacokinetic model'an introduction to recirculatory pharmacokinetic concepts

“…As liver blood¯ow is often a ®xed fraction of cardiac output, the clearance of this group of drugs will also be cardiac output dependent. 27 This may exacerbate any cardiac output dependency in kinetics over that predicted by the present model.…”

The two-compartment recirculatory pharmacokinetic model'an introduction to recirculatory pharmacokinetic concepts

“…As liver blood¯ow is often a ®xed fraction of cardiac output, the clearance of this group of drugs will also be cardiac output dependent. 27 This may exacerbate any cardiac output dependency in kinetics over that predicted by the present model.…”

A Review of Psychophysiological Stressors on Pharmacokinetics

“…shows major changes in blood flow dynamics under acute exercise. Specifically, cardiac output, a determinant of blood drug concentrations, 3 , 4 is 3.5 times at a moderate level of exercise compared with rest.…”

Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise

“…Plasma samples were collected via a catheter placed in the right atrium in the exercising horses and via a jugular catheter in the resting horses. Sampling site can have an effect on drug plasma concentrations if there is inadequate mixing or if one sampling site is immediately downstream from the eliminating organ (Upton 2000). The authors could find no reports documenting differences between jugular and right atrial plasma drug concentrations in horses.…”

The two-compartment recirculatory pharmacokinetic model'an introduction to recirculatory pharmacokinetic concepts

“…As liver blood¯ow is often a ®xed fraction of cardiac output, the clearance of this group of drugs will also be cardiac output dependent. 27 This may exacerbate any cardiac output dependency in kinetics over that predicted by the present model.…”

A Review of Psychophysiological Stressors on Pharmacokinetics

“…shows major changes in blood flow dynamics under acute exercise. Specifically, cardiac output, a determinant of blood drug concentrations, 3 , 4 is 3.5 times at a moderate level of exercise compared with rest.…”

Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise

“…Plasma samples were collected via a catheter placed in the right atrium in the exercising horses and via a jugular catheter in the resting horses. Sampling site can have an effect on drug plasma concentrations if there is inadequate mixing or if one sampling site is immediately downstream from the eliminating organ (Upton 2000). The authors could find no reports documenting differences between jugular and right atrial plasma drug concentrations in horses.…”

The two-compartment recirculatory pharmacokinetic model'an introduction to recirculatory pharmacokinetic concepts

“…As liver blood¯ow is often a ®xed fraction of cardiac output, the clearance of this group of drugs will also be cardiac output dependent. 27 This may exacerbate any cardiac output dependency in kinetics over that predicted by the present model.…”

A Review of Psychophysiological Stressors on Pharmacokinetics

“…shows major changes in blood flow dynamics under acute exercise. Specifically, cardiac output, a determinant of blood drug concentrations, 3 , 4 is 3.5 times at a moderate level of exercise compared with rest.…”

Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise

“…Plasma samples were collected via a catheter placed in the right atrium in the exercising horses and via a jugular catheter in the resting horses. Sampling site can have an effect on drug plasma concentrations if there is inadequate mixing or if one sampling site is immediately downstream from the eliminating organ (Upton 2000). The authors could find no reports documenting differences between jugular and right atrial plasma drug concentrations in horses.…”