Relationships between quality of life, sleep problems, and sleep quality in patients with chronic idiopathic urticaria

Abstract

Background In this study, we aimed to evaluate the sleep quality among chronic urticaria patients using the Chronic Urticaria Quality‐of‐Life Questionnaire (CU–Q2oL), sleep quality assessment tools, and polysomnography and to investigate any relationships between the obtained results. Methods The study included 21 patients diagnosed with chronic spontaneous urticaria and 19 healthy controls. We recorded the patients' sleep quality data, including CU–Q2oL, Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and polysomnography results. Result Patients in the chronic urticaria group were more likely to have an ESS score of ≥10 (52.4% vs. 5.3%, p = 0.004) and an apnea‐hypopnea index of ≥5 (44.4% vs. 5.3%, p = 0.017) compared to the control group. In the patient group, the CU–Q2oL total score was positively correlated with sleep latency (r = 0.713, p = 0.004) and PSQI–C1 score (r = 0.726, p = 0.005), while it was negatively correlated with urticaria duration (r = −0.579, p = 0.015), apnea‐hypopnea index (r = −0.607, p = 0.021), longest apnea duration (r = −0.583, p = 0.029), total number of respiratory events (r = −0.618, p = 0.018), and apnea count (r = −0.686, p = 0.007). Conclusion We conclude that sleep‐related problems exist among a considerably large proportion of patients with chronic spontaneous urticaria.

The Impact of Sleep Quality on Mood Status and Quality of Life in Patients with Alopecia Areata: A Comparative Study

“…A worse sleep quality has been described in a variety of skin diseases, including psoriasis [ 15 ], atopic dermatitis [ 10 ] or chronic spontaneous urticaria [ 11 ]. However, to date, the potential association and implications of a worse sleep quality in patients with AA have not been properly described.…”

“…On the other hand, insomnia and sleep disorders are frequent among the general population [ 5 ] and have been associated with a variety of cardiovascular [ 6 ], neurologic [ 7 ] or psychiatric [ 8 ] complications. Moreover, a worse sleep quality has been described in a variety of chronic skin diseases such as psoriasis [ 9 ], atopic dermatitis [ 10 ] or chronic spontaneous urticaria [ 11 ]. In this regard, recent studies [ 12 ] identify a complex interplay among various physiological, psychosocial and behavioral factors mediating the relationship between sleep loss and chronic inflammatory skin diseases.…”

Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports

“…Melatonin (N-acetyl-5-methoxytryptamine) is a hormone that plays a central role in the sleep cycle. It is mostly produced by the pineal gland from the amino acid tryptophan, and it is secreted into the blood and cerebrospinal fluid [ 1 , 4 ]. Other tissues aside from the epiphysis also produce melatonin, including the retina, bone marrow, gonads, and gastrointestinal mucous, as well as the skin, but the role of melatonin in these tissues is still largely unknown [ 1 ].…”

Sleep Quality as a Predictor of Quality-of-Life and Emotional Status Impairment in Patients with Chronic Spontaneous Urticaria: A Cross-Sectional Study

“…Most commonly used treatments include the use of high-dose antihistamines, with omalizumab being the treatment of choice for cases resistant to antihistamines [ 2 , 5 ]. CSU has been described to impact negatively on the quality of life of patients as a result of the pruritus and visible skin lesions [ 6 , 7 ], therefore leading to emotional status disturbances and poor quality of sleep [ 8 , 9 ].…”

“…Currently, there are a considerable number of studies that explore the impact of poorer sleep quality on the quality-of-life of patients suffering from other pruritic conditions, such as psoriasis [ 10 ] or atopic dermatitis [ 11 ]. However, evidence of the impact of sleep quality on patients with urticaria has been very scarcely discussed in the scientific literature [ 9 ], with scientific reports showing a poor quality of sleep and poor quality of life, but without exploring the impact on emotional status and other spheres of the quality of life. More in-depth research on these topics would be of great interest because of the increasing evidence on the role that poor sleep quality could play in the development of significant neuro-psychiatric [ 12 , 13 ] and cardiovascular [ 14 ] complications.…”