Relationships between Inflammation, Adiponectin, and Oxidative Stress in Metabolic Syndrome

Abstract

Metabolic syndrome (MS) represents a cluster of physiological and anthropometric abnormalities. The purpose of this study was to investigate the relationships between the levels of inflammation, adiponectin, and oxidative stress in subjects with MS. The inclusion criteria for MS, according to the Taiwan Bureau of Health Promotion, Department of Health, were applied to the case group (n = 72). The control group (n = 105) comprised healthy individuals with normal blood biochemical values. The levels of inflammatory markers [high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6), adiponectin, an oxidative stress marker (malondialdehyde), and antioxidant enzymes activities [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] were measured. Subjects with MS had significantly higher concentrations of inflammatory markers and lower adiponectin level, and lower antioxidant enzymes activities than the control subjects. The levels of inflammatory markers and adiponectin were significantly correlated with the components of MS. The level of hs-CRP was significantly correlated with the oxidative stress marker. The IL-6 level was significantly correlated with the SOD and GPx activities, and the adiponectin level was significantly correlated with the GPx activity. A higher level of hs-CRP (≥1.00 mg/L), or IL-6 (≥1.50 pg/mL) or a lower level of adiponectin (<7.90 µg/mL) were associated with a significantly greater risk of MS. In conclusion, subjects suffering from MS may have a higher inflammation status and a higher level of oxidative stress. A higher inflammation status was significantly correlated with decreases in the levels of antioxidant enzymes and adiponectin and an increase in the risk of MS.

The Glucagon-Like Peptide-1 Analogue Liraglutide Inhibits Oxidative Stress and Inflammatory Response in the Liver of Rats with Diet-Induced Non-alcoholic Fatty Liver Disease

“…26) Additionally, a significant correlation between adiponectin, inflammatory markers and oxidative stress has been observed in patients with metabolic syndrome. 27) Liraglutide has been reported to significantly increase plasma adiponectin levels and adiponectin protein expression in adipose tissue in the mice with high fat diet-induced NAFLD. 28) However, whether liraglutide can also elevate the adiponectin levels in the liver is not yet established.…”

Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease

“…As a consequence, the oxidative stress generated by the severe inflammation contributes to valve damage [5]. A study by Chen et al (2012) showed that the increased inflammation was significantly correlated to the increase of oxidative stress. Under stressful conditions such as inflammatory processes mediated by oxidative stress, the cell surface undergo glycosylation and thus can be targeted in MBL/ficolin binding.…”

“…Under stressful conditions such as inflammatory processes mediated by oxidative stress, the cell surface undergo glycosylation and thus can be targeted in MBL/ficolin binding. This in turn will lead to pathological complement activation, and inflammation [26]. In vitro studies showed that oxidative stress caused formation of MBL ligand activating complement in the endothelial cells [2].…”

The factor of fibroblacts-21 growth in the blood of patients with non-alcocholic fatty disease of liver at the background of hypertonic disease

“…В Україні також третина насе-лення хворіє на ГХ [4,5]. На сучасному етапі доведе-ний зв'язок НАЖХП з ГХ, а сам факт розвитку зазна-ченої патології змінює прогноз для таких пацієнтів як щодо прогресування печінкової недостатності, так і в плані значного підвищення частоти ускладнень серцево-судинних захворювань (ССЗ).…”