Relationships Between Cerebral Atrophy Imaged by CT Scanning and Neuropsychological Test Results In Alzheimer's Disease

Disease, Alzheimer’s; Feher, Edward P.; Largen, John W.; Barr, Deborah L.; Smith, Robert C.

doi:10.3109/00207458409089825

Cited by 1 publication

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“…Although only GABAergic terminals establish axo-somatic synapses, both glutamatergic and GABAergic terminals are typically found in the perisomatic region (Merchan-Perez et al, 2009). This is in line with other studies suggesting that GABAergic circuits in the cerebral cortex of AD patients are relatively well preserved when compared to circuits that use other neurotransmitters (Young, 1987; Lowe et al, 1988; Reinikainen et al, 1988; Ferrer et al, 1991; Hof et al, 1991; Nägga et al, 1999; Bell et al, 2003; Rissman et al, 2007). However, other studies indicated possible alterations to the PV-ir basket and chandelier cells in the cerebral cortex of AD patients that are responsible for the GABAergic pericellular innervation of pyramidal cells (DeFelipe et al, 1989; reviewed in Jones, 1993; Freund and Buzsaki, 1996; DeFelipe, 1999).…”

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confidence: 89%

Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer’s disease patients

2010

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Neurofibrillary tangles (NFT) represent one of the main neuropathological features in the cerebral cortex associated with Alzheimer's disease (AD). This neurofibrillary lesion involves the accumulation of abnormally hyperphosphorylated or abnormally phosphorylated microtubule-associated protein tau into paired helical filaments (PHF-tau) within neurons. We have used immunocytochemical techniques and confocal microscopy reconstructions to examine the distribution of PHF-tau-immunoreactive (ir) cells, and their perisomatic GABAergic and glutamatergic innervations in the hippocampal formation and adjacent cortex of AD patients. Furthermore, correlative light and electron microscopy was employed to examine these neurons and the perisomatic synapses. We observed two patterns of staining in PHF-tau-ir neurons, pattern I (without NFT) and pattern II (with NFT), the distribution of which varies according to the cortical layer and area. Furthermore, the distribution of both GABAergic and glutamatergic terminals around the soma and proximal processes of PHF-tau-ir neurons does not seem to be altered as it is indistinguishable from both control cases and from adjacent neurons that did not contain PHF-tau. At the electron microscope level, a normal looking neuropil with typical symmetric and asymmetric synapses was observed around PHF-tau-ir neurons. These observations suggest that the synaptic connectivity around the perisomatic region of these PHF-tau-ir neurons was apparently unaltered.

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