Relationships between alcoholic beverages and cardiovascular risk factor levels in middle-aged men, the PRIME study

Marques‐Vidal, Pedro; Montaye, Michèle; Haas, Bernadette; Bingham, Annie; Evans, Alun; Juhan‐Vague, I.; Ferrières, Jean; Luc, Gérald; Amouyel, Philippe; Arveiler, Dominique; Yarnell, John; Ruidavets, Jean Bernard; Scarabin, Pierre‐Yves; Ducimetière, Pierre

doi:10.1016/s0021-9150(00)00734-6

Cited by 43 publications

(33 citation statements)

References 62 publications

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“…19 In this study, increasing wine consumption was more related to increased HDL cholesterol level. The direct link between wine and HDL cholesterol level is in agreement with some studies 7,20 but not with others. 21 Possible main confounders include the higher socioeconomic status or the healthier behaviors of wine drinkers 21 or the fact that the major beverage type consumed by a population, wine in this population, has often been shown to have the strongest and most significant association with cardiovascular risk factors.…”

Section: Discussionsupporting

confidence: 90%

“…The increase in HDL cholesterol level with total alcohol consumption has been previously described 7,19 and is presumed to be the main mechanism for the protective effect of moderate alcohol consumption on CAD. 19 In this study, increasing wine consumption was more related to increased HDL cholesterol level.…”

Section: Discussionmentioning

confidence: 78%

“…5,20 Multivariate analysis showed no effect of wine on triglycerides but did show effects of spirits and beer, similar to previous studies. 7,21 However, residual confounding due to incomplete adjustment cannot be ruled out, and further studies are needed to better assess the specific effects of beverage types on triglyceride levels. The direct association between the level of alcohol consumption and blood pressure is in agreement with previous research, 7,20 and this study provides additional information on the effect of high levels of alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

“…4,6 Three different types of alcoholic beverages were considered in this study: wine, beer, and spirits. 7 Self-reported alcohol consumption was partially validated by measuring the blood levels of carbohydrate-deficient transferrin (CDT; a combination of asialotransferrin and disialotransferrin). CDT separation was obtained by capillary electrophoresis on a P/ACE 5510 System (Beckman Coulter Instruments, Nyon, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

“…7 The standardized regression coefficients represent the change in the dependent variables that resulted from a change of 1 SD in each of the independent variables.…”

mentioning

confidence: 99%

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Alcohol Drinking and Cardiovascular Risk in a Population With High Mean Alcohol Consumption

Foerster

Marques‐Vidal

Gmel

et al. 2009

The American Journal of Cardiology

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107

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Moderate alcohol consumption has been associated with lower coronary artery disease (CAD) risk. However, data on the CAD risk associated with high alcohol consumption are conflicting. The aim of this study was to examine the impact of heavier drinking on 10-year CAD risk in a population with high mean alcohol consumption. In a population-based study of 5,769 adults (aged 35 to 75 years) without cardiovascular disease in Switzerland, 1-week alcohol consumption was categorized as 0, 1 to 6, 7 to 13, 14 to 20, 21 to 27, 28 to 34, and >35 drinks/week or as nondrinkers (0 drinks/week), moderate (1 to 13 drinks/ week), high (14 to 34 drinks/week), and very high (>35 drinks/week). Blood pressure and lipids were measured, and 10-year CAD risk was calculated according to the Framingham risk score. Seventy-three percent (n ‫؍‬ 4,214) of the participants consumed alcohol; 16% (n ‫؍‬ 909) were high drinkers and 2% (n ‫؍‬ 119) very high drinkers. In multivariate analysis, increasing alcohol consumption was associated with higher high-density lipoprotein cholesterol (from a mean ؎ SE of Increasing wine consumption was more related to high-density lipoprotein cholesterol levels, whereas beer and spirits were related to increased triglyceride levels. In conclusion, as measured by 10-year CAD risk, the protective effect of alcohol consumption disappears in very high drinkers, because the beneficial increase in high-density lipoprotein cholesterol is offset by the increases in blood pressure levels.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…7 The standardized regression coefficients represent the change in the dependent variables that resulted from a change of 1 SD in each of the independent variables.…”

mentioning

confidence: 99%

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