Relationship of Plasma Leptin to Plasma Cytokines and Human Survivalin Sepsis and Septic Shock

Arnalich, Francisco; López, Julia; Codoceo, Rosa; Jiménez, Manuel L.; Madero, Rosário; Montiel, Carmen

doi:10.1086/314963

Cited by 166 publications

(115 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LPS challenge in vivo induced a rapid increase, with peak concentration occurring 3-8 h postchallenge (54,77 ). In reported studies, IL-10 concentrations were increased (22-383 ng/L) in septic adults, whereas it was undetectable in all control and healthy individuals, with the exception in one study (55,58,74,77,83 ). However, IL-10 concentrations are reported to increase within 2 h of blunt trauma, in correlation with injury severity (84 ), and in uninfected surgical patients (83 ), indicating a tendency to participate in the general compensatory antiinflammatory response syndrome.…”

Section: Biomarker Detectionmentioning

confidence: 84%

Toward Resolving the Challenges of Sepsis Diagnosis

Scott²,

2004

View full text Add to dashboard Cite

Sepsis in the UnitedStates has an estimated annual healthcare cost of $16.7 billion and leads to 120 000 deaths. Insufficient development in both medical diagnosis and treatment of sepsis has led to continued growth in reported cases of sepsis over the past two decades with little improvement in mortality statistics. Efforts over the last decade to improve diagnosis have unsuccessfully sought to identify a "magic bullet" proteic biomarker that provides high sensitivity and specificity for infectious inflammation. More recently, genetic methods have made tracking regulation of the genes responsible for these biomarkers possible, giving current research new direction in the search to understand how host immune response combats infection. Despite the breadth of research, inadequate treatment as a result of delayed diagnosis continues to affect approximately one fourth of septic patients. In this report we review past and present diagnostic methods for sepsis and their respective limitations, and discuss the requirements for more timely diagnosis as the next step in curtailing sepsis-related mortality. We also present a proposal toward revision of the current diagnostic paradigm to include real-time immune monitoring.

show abstract

Section: Biomarker Detectionmentioning

confidence: 84%

Toward Resolving the Challenges of Sepsis Diagnosis

Scott²,

2004

View full text Add to dashboard Cite

show abstract

“…In humans, plasma leptin is elevated in septic patients, and a positive correlation between circulating leptin levels and survival after sepsis has been observed [107][108].…”

Section: Leptin and Acute Inflammationmentioning

confidence: 99%

Leptin and Inflammation

Iikuni¹,

Lam²,

Lu³

et al. 2008

CIR

303

251

View full text Add to dashboard Cite

The past few years of research on leptin have provided important information on the link between metabolism and immune homeostasis. Adipocytes influence not only the endocrine system but also the immune response through several cytokine-like mediators known as adipokines, which include leptin. It is widely accepted that leptin can directly link nutritional status and pro-inflammatory T helper 1 immune responses, and that a decrease of leptin plasma concentration during food deprivation can lead to an impaired immune function. Additionally, several studies have implicated leptin in the pathogenesis of chronic inflammation, and the elevated circulating leptin levels in obesity appear to contribute to the low-grade inflammatory background which makes obese individuals more susceptible to increased risk of developing cardiovascular diseases, type II diabetes, or degenerative disease including autoimmunity and cancer. Conversely, reduced levels of leptin such as those found in malnourished individuals have been linked to increased risk of infection and reduced cell-mediated immune responses. We discuss here the functional influences of leptin in the physiopathology of inflammation, and the effects of leptin in the modulation of such responses.

show abstract

“…Finally, we did not measure serum VLDL and cholesterol levels to assess whether there was a correlation between the measured parameters and the severity of the disease. Although changes of leptin may be related to changes in total cholesterol, serum triglycerides, and VLDL, it has been demonstrated that leptin is associated with many other systemic diseases such as acute phase response, endotoxemia, sepsis and Eye septic shock 32,33 with no connection to the plasma VLDL and cholesterol status. Indeed, Thong et al 21 studied plasma leptin levels in female athletes to relate it with body fat, nutritional, and endocrine factors, but did not measure plasma lipid status.…”

Section: Discussionmentioning

confidence: 99%

Serum leptin concentrations are decreased and correlated with disease severity in age-related macular degeneration: a preliminary study

Evereklioğlu

Doğanay

et al. 2003

Eye

View full text Add to dashboard Cite

Background Age-related maculopathy (ARM) or degeneration (ARMD) is the leading cause of irreversible blindness in developed countries. Despite several studies on the morphology of ARMD, the aetiology is unknown and factor(s) contributing to the pathogenesis remain to be characterised. More recent studies have demonstrated that cholesterol esters and lipids are present within Bruch's membrane deposits and drusen, and dietary fat intake is associated with ARMD. The product of Ob gene, leptin, is a recently discovered peptide participating in human metabolism. There is a direct relationship between serum leptin and diet, and lipoprotein metabolism, but the role of leptin in the course of ARMD has not previously been investigated. Purpose This cross-sectional case-control study investigated whether serum leptin level was associated with ARMD as a new possible risk factor and to assess its relationship with disease severity. Methods A total of 32 patients with ARM or ARMD (17 men, 15 women) and 20 age-and sex-matched healthy control subjects without ARMD (11 men, nine women) from a similar ethnic background were enrolled in this multicentre study. Body mass index (BMI) (weight (kg)/height (m 2 )) was calculated for

show abstract

Relationship of Plasma Leptin to Plasma Cytokines and Human Survivalin Sepsis and Septic Shock

Cited by 166 publications

References 13 publications

Toward Resolving the Challenges of Sepsis Diagnosis

Toward Resolving the Challenges of Sepsis Diagnosis

Leptin and Inflammation

Serum leptin concentrations are decreased and correlated with disease severity in age-related macular degeneration: a preliminary study

Contact Info

Product

Resources

About