Relationship of Baseline Serum Cholesterol Levels in 3 Large Cohorts of Younger Men to Long-term Coronary, Cardiovascular, and All-Cause Mortality and to Longevity

Abstract

These results demonstrate a continuous, graded relationship of serum cholesterol level to long-term risk of CHD, CVD, and all-cause mortality, substantial absolute risk and absolute excess risk of CHD and CVD death for younger men with elevated serum cholesterol levels, and longer estimated life expectancy for younger men with favorable serum cholesterol levels. JAMA. 2000;284:311-318

Association of four lipid components with mortality, myocardial infarction, and stroke in statin-naïve young adults: A nationwide cohort study

“…Of note, the present study revealed that the majority of clinical events occurred before the age of 45 years. Thus, unlike the earlier reports showing the effect of dyslipidaemia detected in their 20 s on midlife CVD, 17–19 the present study suggests that dyslipidaemia could determine clinical events earlier in life. Therefore, dyslipidaemia could be involved in short-term as well as long-term prognosis for young adults, and earlier and active intervention for lipids might be beneficial to improve the prognosis.…”

Lipid Profiles and Associated Gene Polymorphisms in Young Asian Indian Patients With Acute Myocardial Infarction and the Metabolic Syndrome

“…When lipid values were analyzed independently of the metabolic syndrome, hypercholesterolemia (83.1%) and increased LDL-C (81.3%) were found to occur most frequently. These results are in agreement with a previously reported epidemiologic study, which showed a continuous graded relationship between the serum total plasma cholesterol concentration and coronary risk in young patients 16. Interestingly, low HDL-C (67.5%) and hypertriglyceridemia (62.5%), which are important components of the metabolic syndrome, were observed less frequently in our subjects.…”

Impact of a family history of cardiovascular disease on prevalence, awareness, treatment, control of dyslipidemia, and healthy behaviors: Findings from the Korea National Health and Nutrition Examination Survey

“…This suggests that individuals with an FH of CVD are at a higher risk of developing dyslipidemia. In fact, these results are expected because both the FH of CVD and dyslipidemia are well-known risk factors for CVD occurrence [5,28,29]. The results of previous studies were also consistent with ours, as the FH of CVD group displayed significantly higher dyslipidemia prevalence [12,15,30].…”