Relationship of bacterial species to the pathogenesis of hematogenous pyelonephritis

Braude, Abraham I.; Shapiro, Anna; Siemienski, Jennie

doi:10.1016/0002-9343(56)90218-2

Cited by 13 publications

(17 citation statements)

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“…Together with the faecal studies ( Table 6) this suggests that, as in humans, the bacteria found in UTI have a faecal origin. The earlier average age at death of the EA MM pyelonephritics (Tables 1 and 7) was a consequence of the acute nature of Proteus mirabilis UTI (Braude, Siemienski & Shapiro, 1960;Taylor, Fraser & Bruce, 1988). However, the average age at death of animals without renal complications is also much lower in EA.…”

Section: Discussionmentioning

confidence: 90%

A shift from acute to chronic spontaneous pyelonephritis in male MM mice associated with a change in the causal micro-organisms

Taylor

1988

Lab Anim

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27Summary Proteus mirabilis was the predominant cause of acute diabetes-associated pyelonephritis occurring spontaneously in male MM mice until they were segregated in a new environment. Thereafter Pasteurella pneumotropica and Streptococcus faecalis emerged collectively as the most common causal organisms, the pyelonephritis became more chronic and Proteus mirabilis iso· lates from faeces and urine produced atypical non-swarming colonies on blood agar plates. This did not account for the reduced pathogenicity of Proteus mirabilisj when MM males were returned to the original environment the pyelonephritis again became acute but was associated with the atypical type of Proteus mirabilis although the normal type was abundant in the environment.The MM mice were Caesarian-derived and cross-fostered shortly before their transfer to the second environment, which probably accounts for their changed microbial status, but the reason for the emergence of the atypical type of Proteus mirabilis is not understood. The acute nature of the male MM pyelonephritis when caused by Proteus mirabilis parallels the situation described in other animals and humans.

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Section: Discussionmentioning

confidence: 90%

A shift from acute to chronic spontaneous pyelonephritis in male MM mice associated with a change in the causal micro-organisms

Taylor

1988

Lab Anim

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“…Furthermore, the consequences of infection with Proteus spp. are often more serious because, whereas E. coli is usually confined to the bladder, Proteus strains have a special predilection for the upper urinary tract (Fairley et al, 1971) where they may cause damage to the renal tubular epithelium (Braude et al, 1960) and bring about conditions leading to the formation of renal stones (Griffith et al, 1973). On the other hand, Morganella morgani and Providencia spp.…”

Section: Introductionmentioning

confidence: 99%

A survey of IgA protease production among clinical isolates of Proteeae

Senior

Albrechtsen

Kerr

1988

Journal of Medical Microbiology

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Summary.A collection of 100 strains of Proteeae, in which all species within the tribe were represented, was examined for IgA protease production. The strains were isolated from various clinical specimens from sick and healthy persons in several countries. IgA protease-producing strains were not found amongst species of Providencia and Morganella but were common in Proteus spp. All the strains of P. mirabilis and P. penneri and many of the strains of P. vulgaris examined produced an EDTA-sensitive protease that cleaved the IgA heavy chain outside the hinge region. The proteus enzyme was different in this respect from the EDTA-sensitive, hingecutting proteases of other bacteria. The ability to produce IgA protease was unrelated to the 0 antigenicity, biotype or bacteriocin type of the strain. IgA protease production may be an important virulence mechanism for Proteus strains.

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“…As a result of urease activity (Senior, Bradford and Simpson, 1980) the urine rapidly becomes alkaline. This leads to necrosis of the renal tubular epithelium (Braude, Siemienski and Shapiro, 1960) and the formation of renal stones (Griffith, Musher and Campbell, 1973).…”

Section: Introductionmentioning

confidence: 99%

A highly discriminatory multi-typing scheme for Proteus mirabilis and Proteus vulgaris

Senior

Larsson

1983

Journal of Medical Microbiology

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SUMMARY. Strains of Proteus mirabilis and P. vulgaris isolated inEngland, Scotland and Sweden were characterised by proticine production-proticine sensitivity (P-S) typing, 0 serotyping and Dienes typing methods. The determinants of 0 antigenicity were independent of those determining proticine production and proticine sensitivity. Because of this independence, the combination of P-S typing and 0 serotyping for the analysis of the 133 serotypable strains separated them into 81 distinct types whereas P-S typing and 0 serotyping methods alone separated them into only 56 and 19 types respectively. There was a relationship between the Dienes type and the P-S type; the determinants of Dienes compatibility were the proticine production-proticine sensitivity characters. The determinants of 0 antigenicity appeared to play no role in the Dienes reaction. Some strains that were indistinguishable by P-S typing and 0 serotyping methods were distinguished by Dienes typing.

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Relationship of bacterial species to the pathogenesis of hematogenous pyelonephritis

Cited by 13 publications

References 0 publications

A shift from acute to chronic spontaneous pyelonephritis in male MM mice associated with a change in the causal micro-organisms

A shift from acute to chronic spontaneous pyelonephritis in male MM mice associated with a change in the causal micro-organisms

A survey of IgA protease production among clinical isolates of Proteeae

A highly discriminatory multi-typing scheme for Proteus mirabilis and Proteus vulgaris

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