Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy

Abstract

Homozygous BclI G allele carriers are at risk for traumatic memories, posttraumatic stress disorder symptoms, and lower health-related quality of life after cardiac surgery and intensive care unit therapy. The BclI single-nucleotide polymorphism may help to identify individuals at need for tailored medical care.

Glucocorticoid receptor genetic polymorphisms is associated with improvement of health-related quality of life in Chinese population with systemic lupus erythematosus

“…The GR gene has been suggested to be a candidate gene affecting depression risk and management [19]. Recently, Hauer et al [20] studied the association of the GR gene BclI polymorphism with HRQOL in 126 patients undergoing cardiac surgery and intensive care unit therapy, and they found that homozygous BclI G allele carriers were at risk for lower HRQOL after cardiac surgery and intensive care unit therapy. Considering the above evidences, it is possible that genetic polymorphisms within GR gene are related to improvement of HRQOL in SLE patients treated with GCs.…”

Stress-induced neuroplasticity: (Mal)adaptation to adverse life events in patients with PTSD – A critical overview

“…With respect to the subgroup of PTSD patients characterized by hypocortisolism, genetic studies have shown a Bcll polymorphism that encodes the GR gene to be associated with glucocorticoid hypersensitivity which is in line with the increased negative feedback hypothesis. This view is further supported by an association between this genetic variant and an increased risk to develop PTSD symptoms after trauma exposure (Hauer et al, 2011). Intriguingly, the same polymorphism has also been found to be associated with better memory performance for emotional pictures in healthy subjects (Ackermann et al, 2013).…”

The BclI polymorphism of the glucocorticoid receptor gene is associated with emotional memory performance in healthy individuals

“…According to the study of Hauer et al (2011), we compared GG vs. GC and CC carriers, as the recessive model of inheritance best described the effect of the BclI polymorphism on memory. Gender was included as covariate because of significant gender effects on picture recall and arousal/valence ratings.…”

“…In analogy to the paper of Hauer et al (2011), we compared GG carriers with C-allele carriers. For short delay recall of pictures, we observed a significant picture valence  genotype interaction (F(1, 838) = 4.87, p = 0.03).…”

“…Recently, Hauer et al (2011) investigated whether the BclI polymorphism is related to memory for traumatic events in the setting of cardiac surgery. The authors measured memory for traumatic events from intensive care unit and PTSD symptoms using a standardized and validated questionnaire (Stoll et al, 1999).…”