2018
DOI: 10.3389/fendo.2018.00448
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Abstract: Introduction: Recent studies have demonstrated that vitamin D deficiency contributes to the development of metabolic disorders, including obesity and type 2 diabetes mellitus (T2DM). Several vitamin D receptor (VDR) gene polymorphisms had been described to play a role in these conditions since vitamin D receptors were found in many tissues. The aim of this study was to assess the relationship between vitamin D status and VDR gene polymorphisms with metabolic syndrome (MS) parameters in Russian middle-aged wome… Show more

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Cited by 36 publications
(23 citation statements)
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“…status (25,52). However, we found no significant difference in circulating calcidiol concentrations among VDR FokI variants.…”
Section: Several Studies Have Examined the Possible Interactions Betwcontrasting
confidence: 70%
“…status (25,52). However, we found no significant difference in circulating calcidiol concentrations among VDR FokI variants.…”
Section: Several Studies Have Examined the Possible Interactions Betwcontrasting
confidence: 70%
“…The gene encoding for VDR is located on the long arm of chromosome 12 (locus 12q12-q14) [13]. VDR single nucleotide polymorphisms (SNPs) have been identified, and their association with vitamin D status or risk of CVD, diabetes, obesity, hypertension, tuberculosis, and breast cancer has been reported in different ethnicities [14][15][16][17][18][19]. However, all these studies, especially in the Middle East region, analysed few VDR SNPs in relation to CVD risk factors [20][21][22][23][24].…”
Section: Introductionmentioning
confidence: 99%
“…This was mainly because of the sequestration of vitamin D in the body fat compartment, which could lead to the reduction of the bioavailability of vitamin D that was either photosynthesized through the skin by direct exposure to sunlight or from dietary sources (28). Other researchers have revealed the correlation of obesity with hypovitaminosis D with enhanced catabolism of the said vitamin in fat tissues and their conversion into inactive metabolites (29).…”
Section: Discussionmentioning
confidence: 99%