Relationship Between Vitamin D Status and Vitamin D Receptor Gene Polymorphisms With Markers of Metabolic Syndrome Among Adults

Background: Sunlight exposure, the main source of endogenous vitamin D synthesis, may increase the risk of non-melanoma skin cancer (NMSC) development. Vitamin D receptor (VDR) polymorphisms are associated with 25(OH)D levels, cancer development and insulin resistance. This study was aimed to examine the associations among vitamin D status, VDR FokI polymorphism, insulin resistance and NMSC. Methods: This case-control study included 73 diagnosed cases of NMSC and 72 healthy controls from dermatology clinics at Razi Hospital, Tehran, Iran. A questionnaire was used to assess sunlight exposure. The extracted DNA from whole blood samples were genotyped. Fasting serum 25-hydroxyvitaminD (25(OH)D)), lipid profile, glucose, and insulin were measured. To evaluate insulin resistance, HOMA-IR formula was used. Results: We found a significant higher duration of cumulative sunlight exposure in cases compared with controls (p<0.001). However, 25(OH)D concentrations were not significantly different between cases and controls (30±15 vs. 29±15 ng/mL, p=0.78). Higher levels of insulin (p = 0.004) and HOMA-IR score (p= 0.019) were observed in Ff and ff genotype of FokI. We did not observe any significant increased risk of NMSC due to f allele, as compared with FF (OR =2.33, 95% CI 0.81-6.75, p=0.12). The components of lipid profile, fasting serum glucose, iPTH and anthropometric measures did not differ significantly across VDR genotypes. Conclusion: In conclusion, sunlight exposure was associated with NMSC risk. VDR FokI polymorphisms appears to influence insulin resistance in the NMSC patients. Keywords: sun exposure; non-melanoma skin cancer; polymorphisms; insulin resistance

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“…The gene encoding for VDR is located on the long arm of chromosome 12 (locus 12q12-q14) [13]. VDR single nucleotide polymorphisms (SNPs) have been identified, and their association with vitamin D status or risk of CVD, diabetes, obesity, hypertension, tuberculosis, and breast cancer has been reported in different ethnicities [14][15][16][17][18][19]. However, all these studies, especially in the Middle East region, analysed few VDR SNPs in relation to CVD risk factors [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

FokI vitamin D receptor gene polymorphism and serum 25-hydroxyvitamin D in patients with cardiovascular risk

Nakhl

Sleilaty

Chouery

et al. 2019

Arch Med Sci Atheroscler Dis

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Introduction: The biological actions of vitamin D are mediated through vitamin D receptor (VDR). Numerous single-nucleotide polymorphisms (SNPs) in the VDR gene have been identified, and some have been associated with cardiovascular disease (CVD) risk factors. This study aims to evaluate the association of five SNPs in the VDR gene with 25-hydroxyvitamin D (25[OH]D) levels in patients with at least one CVD risk factor. Material and methods: Genomic DNA was sequenced using standard Sanger methods for five VDR SNPs (BsmI rs1544410; ApaI rs7975232; Cdx2 rs11568820; TaqI rs731236; FokI rs2228570) in 50 Mediterranean subjects having hypovitaminosis D with at least one documented CVD risk factor, aged 18 years or more. The collected variables were serum levels of (25[OH]D), HbA 1c , fasting plasma glucose, triglycerides, LDL cholesterol, and total cholesterol. Results: BsmI, ApaI, and TaqI were moderately to highly intercorrelated. Cdx2 was less frequent than expected. With respect to the number of mutations in FokI, levels of (25 [OH]D) were 11.2 ±5.5 ng/ml in the absence of mutations, 12.6 ±4.7 ng/ml in the presence of one mutation, and 16.5 ± 5.5 ng/ml in the presence of two mutations. Conclusions: FokI polymorphism is more frequent in subjects with cardiovascular risk factors than in the general Caucasian population.

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“…This was mainly because of the sequestration of vitamin D in the body fat compartment, which could lead to the reduction of the bioavailability of vitamin D that was either photosynthesized through the skin by direct exposure to sunlight or from dietary sources (28). Other researchers have revealed the correlation of obesity with hypovitaminosis D with enhanced catabolism of the said vitamin in fat tissues and their conversion into inactive metabolites (29).…”

Section: Discussionmentioning

confidence: 99%

The prevalence of vitamin D deficiency between Saudis and non-Saudis in Al-Madinah Al-Munawarah a cross-sectional study

Nasr

Othman

Hassan

et al. 2019

Preprint

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BackgroundVitamin D, or the “sunshine” hormone became an attractable topic that recently captivates many researchers. The increased prevalence of vitamin D deficiency became an alarming health concern despite the accumulative evidence exploring its crucial role not only in bone metabolism, but also in a variety of pleiotropic functions throughout the various body organs. The aim of this study is to compare the prevalence that might influence vitamin D deficiency among Saudi and non-Saudi nationalities in Almadinah Almunawarh, Saudi Arabia, and to study the different factors that may have an influence in the difference of this prevalence like the marital status, occupation, smoking, sunlight exposure, education, and dietary habits.MethodsThe study was a cross sectional study done in the medical care unit in Taiba University Almadina Almunawarah in which, 65 healthy male individuals from different nationalities (Saudis and non-Saudis), aged 18 - 65 years were divided into 2 groups, 33 Saudis and 32 non-Saudis. A sociodemographic questionnaire was filled by the study participants and 25-OH vitamin D3 (25(OH)D3) concentrations were detected by electrochemiluminescence immunoassay.ResultsResults showed a Significant percentage of the participants in the Saudi group (n = 30, 91%) suffered from deficiency in vitamin D levels [25 (OH) D < 20 ng/ml] 12.57 ± 4.82 (mean ± SD), compared to only 47% (n = 15) in the non-Saudi group [21.56 ± 6.82 (mean ± SD)]. Vitamin D deficiency was found to be significantly higher in the Saudi group than the non-Saudi group with P = 0.001.ConclusionResults showed a significant increase in vitamin D deficiency in Saudi population than the non-Saudis P = 0.001. The occupation status was found to be the only factor positively correlated with vitamin D deficiency.

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“…Recently, the study of these polymorphisms is becoming increasingly popular because their detection can be a reliable diagnostic characteristic in determining the risk of T2D development. The association between VDR polymorphisms and abdominal obesity has shown that patients with Bsm1 and Apa1 polymorphisms have low vitamin D status, which is accompanied by an increase in the concentrations of TC, LDL, and TG [69]. The results of another study show that body weight and BMI were significantly associated with polymorphisms Bsm1 and Taq1, while Bsm1 strongly correlated with elevated HbA1c level.…”

Section: Vitamin D Deficiency and Type 2 Diabetes Mellitusmentioning

confidence: 97%

“…As we mentioned earlier, VD mediates its biological activity through VDR, which belongs to the family of steroid hormone receptors. Many VDR gene SNPs have been identified to be related to T2D, in particular to insulin synthesis and release [69]. The most reported VDR SNPs associated with diabetes are Fok1, Bsm1, Taq1, and Apa1.…”

Section: Vitamin D Deficiency and Type 2 Diabetes Mellitusmentioning

confidence: 99%

Vitamin D Deficiency and Diabetes Mellitus

Shymanskyi¹,

Lisakovska²,

Mazanova³

et al. 2020

Vitamin D Deficiency

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Vitamin D (VD) is a molecule that can be synthesized directly in the humans' body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D-1,25(OH) 2 D. 1,25(OH) 2 D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells' functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.

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Relationship Between Vitamin D Status and Vitamin D Receptor Gene Polymorphisms With Markers of Metabolic Syndrome Among Adults

Cited by 31 publications

References 51 publications

Vitamin D status and its relation with insulin resistance and VDR-FokI polymorphism in Iranian non-melanoma skin cancer (NMSC) patients: a case-control study

FokI vitamin D receptor gene polymorphism and serum 25-hydroxyvitamin D in patients with cardiovascular risk

The prevalence of vitamin D deficiency between Saudis and non-Saudis in Al-Madinah Al-Munawarah a cross-sectional study

Vitamin D Deficiency and Diabetes Mellitus

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