Relationship between time of day and periprocedural myocardial infarction after elective angioplasty

Fournier, Stéphane; Puricel, Serban; Morawiec, Beata; Eeckhout, Éric; Mangiacapra, Fabio; Trana, Catalina; Tapponnier, Maxime; Iglesias, Juan F.; Michiels, Vincent; Stauffer, Jean‐Christophe; Beggah, Ahmed T.; Monney, Pierre; Gobet, Stéphanie; Vogt, Pierre; Cook, Stéphane; Müller, Olivier

doi:10.3109/07420528.2013.839561

Cited by 13 publications

(8 citation statements)

References 28 publications

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“…The evidence of the adverse effect of cortisol on CMC is a clinical study that demonstrates that increased levels of the stress hormone (cortisol) are associated with increased levels of cardiospecific TnT ( Lazzarino et al, 2013 ). In addition, a number of researchers associate the increased high activity of the sympathoadrenal system with a larger size of the focus of myocardial necrosis in MI, the incidence of acute CVD and an unfavorable prognosis ( Manfredini et al, 2004 ; Arroyo Úcar et al, 2012 ; Fournier et al, 2014 ; Seneviratna et al, 2015 ; Roos and Holzmann, 2018 ; Chaulin, 2021 ; Chaulin and Duplyakov, 2021g ; Chaulin, 2021h ; Chaulin and Duplyakov, 2022 ; Mullova et al, 2022 ).…”

Section: Circadian Rhythms Of Cardiospecific Tns: Possible Mechanisms...mentioning

confidence: 99%

Metabolic Pathway of Cardiospecific Troponins: From Fundamental Aspects to Diagnostic Role (Comprehensive Review)

Chaulin

2022

Front. Mol. Biosci.

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Many molecules of the human body perform key regulatory functions and are widely used as targets for the development of therapeutic drugs or as specific diagnostic markers. These molecules undergo a significant metabolic pathway, during which they are influenced by a number of factors (biological characteristics, hormones, enzymes, etc.) that can affect molecular metabolism and, as a consequence, the serum concentration or activity of these molecules. Among the most important molecules in the field of cardiology are the molecules of cardiospecific troponins (Tns), which regulate the processes of myocardial contraction/relaxation and are used as markers for the early diagnosis of ischemic necrosis of cardiomyocytes (CMC) in myocardial infarction (MI). The diagnostic value and diagnostic capabilities of cardiospecific Tns have changed significantly after the advent of new (highly sensitive (HS)) detection methods. Thus, early diagnostic algorithms of MI were approved for clinical practice, thanks to which the possibility of rapid diagnosis and determination of optimal tactics for managing patients with MI was opened. Relatively recently, promising directions have also been opened for the use of cardiospecific Tns as prognostic markers both at the early stages of the development of cardiovascular diseases (CVD) (arterial hypertension (AH), heart failure (HF), coronary heart disease (CHD), etc.), and in non-ischemic extra-cardiac pathologies that can negatively affect CMC (for example, sepsis, chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), etc.). Recent studies have also shown that cardiospecific Tns are present not only in blood serum, but also in other biological fluids (urine, oral fluid, pericardial fluid, amniotic fluid). Thus, cardiospecific Tns have additional diagnostic capabilities. However, the fundamental aspects of the metabolic pathway of cardiospecific Tns are definitively unknown, in particular, specific mechanisms of release of Tns from CMC in non-ischemic extra-cardiac pathologies, mechanisms of circulation and elimination of Tns from the human body, mechanisms of transport of Tns to other biological fluids and factors that may affect these processes have not been established. In this comprehensive manuscript, all stages of the metabolic pathway are consistently and in detail considered, starting from release from CMC and ending with excretion (removal) from the human body. In addition, the possible diagnostic role of individual stages and mechanisms, influencing factors is analyzed and directions for further research in this area are noted.

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Section: Circadian Rhythms Of Cardiospecific Tns: Possible Mechanisms...mentioning

confidence: 99%

Metabolic Pathway of Cardiospecific Troponins: From Fundamental Aspects to Diagnostic Role (Comprehensive Review)

Chaulin

2022

Front. Mol. Biosci.

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“…Эта разница оставалась статистически значимой после коррекции по полу и возрасту (21% vs 29%, p=0,03). Согласно многофакторному анализу, проведение ЧКВ во второй половине дня независимо увеличивает риск развития перипроцедурного ИМ (отношение шансов 2,0; 95% ДИ 1,1-3,4; р=0,02) [35].…”

Section: циркадные ритмы стunclassified

Circadian rhythms of cardiac troponins: mechanisms and clinical significance

2020

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Modern laboratory methods for determining biomarkers of cardiovascular diseases are highly sensitive and can detect almost single molecules in human biological fluids, significantly speeding up and improving the diagnosis of cardiovascular diseases. However, in this case, there is a decrease in specificity and it is necessary to take into account a number of additional factors that may affect the result of the study. Recent studies have shown that circadian rhythms (CR) are among these factors. This review article is devoted to the discussion of recently discovered CR of cardiac troponins (CT). A number of articles reported that, both in healthy people and in patients with a number of chronic diseases, CT concentrations change during the day. Given that modern algorithms for diagnosing myocardial infarction (MI) are based on serial studies (0-1 h and 0-3 h) of blood serum, and the values of CT in the blood serum for the diagnosis of myocardial infarction (MI) for this period of time are only a few ng/l, the CT CR can to some extent affect the accuracy of MI diagnosis. Thus, natural physiological changes in the concentration of CT during the day can be mistakenly interpreted as diagnostically significant deviations and lead to an erroneous interpretation of laboratory test results.

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“…A significantly lower risk of periprocedural MI was actually reported in 308 PS-matched pairs undergoing percutaneous coronary intervention if the procedure was performed in the morning instead of the afternoon. 16 Although there is accumulating evidence that the circadian system may affect cardiovascular disease processes, [17][18][19][20] this might not be evident in the context of surgical procedures. This could possibly be explained by the concept of an interruption of the melatonin-mediated biologic clock under the effect of anesthesia and cardiopulmonary bypass in the perioperative and 48-hour postoperative periods.…”

Section: Commentmentioning

confidence: 99%

Daytime Variation in Aortic Valve Surgery and Clinical Outcome: A Propensity Score–Matched Analysis

Götte

Zittermann

Deutsch

et al. 2020

The Annals of Thoracic Surgery

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Relationship between time of day and periprocedural myocardial infarction after elective angioplasty

Abstract: This observational PS-matched study suggests that the timing of an elective PCI influences the rate of PMI.

Cited by 13 publications

References 28 publications

Metabolic Pathway of Cardiospecific Troponins: From Fundamental Aspects to Diagnostic Role (Comprehensive Review)

Metabolic Pathway of Cardiospecific Troponins: From Fundamental Aspects to Diagnostic Role (Comprehensive Review)

Circadian rhythms of cardiac troponins: mechanisms and clinical significance

Daytime Variation in Aortic Valve Surgery and Clinical Outcome: A Propensity Score–Matched Analysis

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