Relationship Between the Wernicke and the Korsakoff Syndrome

The Relationship Between Korsakov's Syndrome and ‘Alcoholic Dementia’

“…Such abnormalities, although mentioned by Bowman and J ellinek ,( 194I) ' and Talland (1965) are largely neglected by most authors. Persistent delusions and rarely auditory hallucinations found in the present study had already been remarked on by Korsakov (1890), Chotzen (1906) and Malamud and Skillicorn (1956) but forgotten by recent authors, who have tended to disregard all aspects except the failure in memory. Summarizing the investigations in the present series, thiamine metabolism is disrupted in all, liver function in only a minority, and the majority have a disturbance of their electroencephalogram.…”

“…There have however, been quite different estimates of the chances of some recovery, of cognitive functions, with figures ranging from zero to 74 per cent. Malamud and Skillicorn (1956) found no improvement in 70 cases followed for four years; Jolliffe et al (1941) found that only one of their 12 cases was better despite adequate vitamin replacements. Siebert (1933) claimed that 50 per cent of 57 patients recovered sufficiently to be able to work; Moll (1915) found that two-thirds of his had achieved some degree of improvement; Victor et al (1971), in the most comprehensive study 'of all, discovered that of 104 patients followed for five years 2 I per cent recovered completely, 28 per cent showed significant improvement and 25 per cent were slightly improved.…”

The Relationship Between Korsakov's Syndrome and ‘Alcoholic Dementia’

“…Such abnormalities, although mentioned by Bowman and J ellinek ,( 194I) ' and Talland (1965) are largely neglected by most authors. Persistent delusions and rarely auditory hallucinations found in the present study had already been remarked on by Korsakov (1890), Chotzen (1906) and Malamud and Skillicorn (1956) but forgotten by recent authors, who have tended to disregard all aspects except the failure in memory. Summarizing the investigations in the present series, thiamine metabolism is disrupted in all, liver function in only a minority, and the majority have a disturbance of their electroencephalogram.…”

“…There have however, been quite different estimates of the chances of some recovery, of cognitive functions, with figures ranging from zero to 74 per cent. Malamud and Skillicorn (1956) found no improvement in 70 cases followed for four years; Jolliffe et al (1941) found that only one of their 12 cases was better despite adequate vitamin replacements. Siebert (1933) claimed that 50 per cent of 57 patients recovered sufficiently to be able to work; Moll (1915) found that two-thirds of his had achieved some degree of improvement; Victor et al (1971), in the most comprehensive study 'of all, discovered that of 104 patients followed for five years 2 I per cent recovered completely, 28 per cent showed significant improvement and 25 per cent were slightly improved.…”

Defect of memorizing of hippocampal-mammillary origin: a review

“…2 There are no more cortical lesions in their cases than in those described by Gamper (1928) or in two-thirds of the cases described by Malamud and Skillicorn (1956). An association with neuronal or cortical lesions does at times occur, but this merely reflects an associated intellectual degradation which also appears frequently in Korsakovians.…”

Alcoholic Dementia

“…This was first suspected on clinical grounds by Murawieff 6 and Bonhoeffer, 7 but it was Gamper, 8 in 1928, who made the astute observation that Korsakoff psychosis and the confusional state attendant upon Wernicke disease had a similar if not identical pathologic anatomy in the walls of the third and fourth ventricles and aqueduct of Sylvius. This relationship was later affirmed by Malamud and Skillicorn 9 and by Victor et al, 10 whose nutritional, clinical, and neuropathologic studies indicated that the Korsakoff amnesic state is simply the chronic psychologic residual of Wernicke encephalopathy.…”

The Relationship Between Korsakov's Syndrome and ‘Alcoholic Dementia’

“…Such abnormalities, although mentioned by Bowman and J ellinek ,( 194I) ' and Talland (1965) are largely neglected by most authors. Persistent delusions and rarely auditory hallucinations found in the present study had already been remarked on by Korsakov (1890), Chotzen (1906) and Malamud and Skillicorn (1956) but forgotten by recent authors, who have tended to disregard all aspects except the failure in memory. Summarizing the investigations in the present series, thiamine metabolism is disrupted in all, liver function in only a minority, and the majority have a disturbance of their electroencephalogram.…”

“…There have however, been quite different estimates of the chances of some recovery, of cognitive functions, with figures ranging from zero to 74 per cent. Malamud and Skillicorn (1956) found no improvement in 70 cases followed for four years; Jolliffe et al (1941) found that only one of their 12 cases was better despite adequate vitamin replacements. Siebert (1933) claimed that 50 per cent of 57 patients recovered sufficiently to be able to work; Moll (1915) found that two-thirds of his had achieved some degree of improvement; Victor et al (1971), in the most comprehensive study 'of all, discovered that of 104 patients followed for five years 2 I per cent recovered completely, 28 per cent showed significant improvement and 25 per cent were slightly improved.…”

Defect of memorizing of hippocampal-mammillary origin: a review

“…2 There are no more cortical lesions in their cases than in those described by Gamper (1928) or in two-thirds of the cases described by Malamud and Skillicorn (1956). An association with neuronal or cortical lesions does at times occur, but this merely reflects an associated intellectual degradation which also appears frequently in Korsakovians.…”

Alcoholic Dementia

“…This was first suspected on clinical grounds by Murawieff 6 and Bonhoeffer, 7 but it was Gamper, 8 in 1928, who made the astute observation that Korsakoff psychosis and the confusional state attendant upon Wernicke disease had a similar if not identical pathologic anatomy in the walls of the third and fourth ventricles and aqueduct of Sylvius. This relationship was later affirmed by Malamud and Skillicorn 9 and by Victor et al, 10 whose nutritional, clinical, and neuropathologic studies indicated that the Korsakoff amnesic state is simply the chronic psychologic residual of Wernicke encephalopathy.…”

The Relationship Between Korsakov's Syndrome and ‘Alcoholic Dementia’

“…Such abnormalities, although mentioned by Bowman and J ellinek ,( 194I) ' and Talland (1965) are largely neglected by most authors. Persistent delusions and rarely auditory hallucinations found in the present study had already been remarked on by Korsakov (1890), Chotzen (1906) and Malamud and Skillicorn (1956) but forgotten by recent authors, who have tended to disregard all aspects except the failure in memory. Summarizing the investigations in the present series, thiamine metabolism is disrupted in all, liver function in only a minority, and the majority have a disturbance of their electroencephalogram.…”

“…There have however, been quite different estimates of the chances of some recovery, of cognitive functions, with figures ranging from zero to 74 per cent. Malamud and Skillicorn (1956) found no improvement in 70 cases followed for four years; Jolliffe et al (1941) found that only one of their 12 cases was better despite adequate vitamin replacements. Siebert (1933) claimed that 50 per cent of 57 patients recovered sufficiently to be able to work; Moll (1915) found that two-thirds of his had achieved some degree of improvement; Victor et al (1971), in the most comprehensive study 'of all, discovered that of 104 patients followed for five years 2 I per cent recovered completely, 28 per cent showed significant improvement and 25 per cent were slightly improved.…”

Defect of memorizing of hippocampal-mammillary origin: a review

“…2 There are no more cortical lesions in their cases than in those described by Gamper (1928) or in two-thirds of the cases described by Malamud and Skillicorn (1956). An association with neuronal or cortical lesions does at times occur, but this merely reflects an associated intellectual degradation which also appears frequently in Korsakovians.…”

Alcoholic Dementia

“…This was first suspected on clinical grounds by Murawieff 6 and Bonhoeffer, 7 but it was Gamper, 8 in 1928, who made the astute observation that Korsakoff psychosis and the confusional state attendant upon Wernicke disease had a similar if not identical pathologic anatomy in the walls of the third and fourth ventricles and aqueduct of Sylvius. This relationship was later affirmed by Malamud and Skillicorn 9 and by Victor et al, 10 whose nutritional, clinical, and neuropathologic studies indicated that the Korsakoff amnesic state is simply the chronic psychologic residual of Wernicke encephalopathy.…”