Relationship between the modal class of cells and the morphological and functional state of population

Shabalkin, I. P.; Bogush, I. G.; Yagubov, A. S.; Шабалкин, П. И.; Mamontov, S. G.; Minaev, V. I.

doi:10.1007/s10630-005-0047-4

Cited by 3 publications

(5 citation statements)

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“…It should be noted that the hypothesis on the interrupted nature of DNA synthesis was put forward by some authorities [4,7,9,13], and was even experimentally proven [8]. Thus, we can conclude that the process of biochemical evolution of biopolymers led to the appearance of mechanisms based on the principle of maximum structural compaction in a limited space.…”

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confidence: 69%

Compaction Principle and Approaches to Biopolymer Structure Deciphering

Shabalkin

Шабалкин

2010

Bull Exp Biol Med

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On the basis of a principle of maximum compaction of biopolymer structure in a limited space derived from the concept about the existence of three different types of dimers in the studied structure, we propose a hypothesis according to which side groups in macromolecules (nitrogenous bases in nucleic acids or R-groups in proteins) are specifically distributed in different points depending on geometrical shape of dimer bending in the biopolymer chain backbone. The latter provides the possibility of complete deciphering of biopolymer structure.

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confidence: 69%

Compaction Principle and Approaches to Biopolymer Structure Deciphering

Shabalkin

Шабалкин

2010

Bull Exp Biol Med

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“…Starting from 94 h (20.2%), PLM steadily increased and peaked at 102 h (40.4%), thereafter the percent of labeled mitoses decreased at 106 to 19.6%. This wavy pattern of the curve is probably related to the phenomenon of DNA synthesis discontinuity in eukaryotic cells [3,4,6,7]. The fact that PLM was minimum from 38 to 94 h (on average, it did not exceed 10%) attests to the beginning of a new wave of PLM related to S period of the second mitotic cycle.…”

Section: Resultsmentioning

confidence: 99%

“…where t m is the duration of mitosis that in mouse corneal epithelial cells can vary from 1.1 to 4.1 h over the day [1,4]. Under these conditions, g 1 period varies on average from 55 to 58 h. Experimental data suggest that normally, S period of corneal epithelial cells includes several stages separated by intervals without DNA synthesis.…”

Section: Resultsmentioning

confidence: 99%

Effect of Irradiation on DNA Synthetic Period of the Mitotic Cycle in Cells

et al. 2012

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Kinetics of DNA synthesis in mitotic cycle of mouse corneal epithelial cells after single γ-irradiation (4 Gy) at the end of S period was studied by the method of radioautography. Normally, S period of corneal epithelial cells consists of several stages separated by intervals without DNA synthesis. The estimated mean duration of the first (S(1)) and second (S(2)) phases of S period was 16 and 10 h, respectively, and the interval between them was 7 h. Single irradiation at the end of S period changed the duration of mitotic cycle periods: S(2) phase became 2.2-longer than S(1) phase and the duration of g(1) period decreased, because the time for reparation in irradiated cell increases at the expense of g(1) period. Shortening of g(1) period is a factor promoting the appearance of transformed cells.

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“…In children with acute lymphoblastic leukemia in remission, the changes in the qualitative composition of bone marrow cell population precede the onset of a relapse [9]. Study of patient' bone marrow cell population by the morphological method (by the percentage of blast cells) showed that the content of cells deviating from the norm by the functional activity of cell genome surpassed 33% (C parameter) 3-13 months before clinical manifestation of a relapse.…”

Section: Resultsmentioning

confidence: 99%

“…No direct proofs of the existence of the "threshold" determining the moment when the biological system passes to a qualitatively new level were found. But we hope it will be possible to find it if we regard a multicellular organism as a community of descendants from the same maternal cell (zygote), differing from each other only by the level of functional activity of their genome [9], as the differential activity of the genes determines the function of the cell population. In this case it is essential to know at least the criterion of cell function and the number of cells whose function has shifted from the population function before transition by the moment of this transition.…”

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confidence: 99%