Relationship between the hyperinsulinemic–euglycaemic clamp and a new simple index assessing insulin sensitivity in overweight and obese postmenopausal women

Bastard, Jean‐Philippe; Vandernotte, J.M.; Faraj, May; Karelis, AD; Messier, Lyne; Malita, F.M.; Garrel, Dominique R.; Prud’homme, Denis; Rabasa‐Lhoret, Rémi

doi:10.1016/j.diabet.2007.02.004

Cited by 66 publications

(39 citation statements)

References 19 publications

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“…30 Fasting insulin sensitivity indices, homeostasis model assessment for insulin resistance and quantitative insulin sensitivity check index, were calculated as published. 31 Lipoprotein size and cholesterol concentrations were measured by an automated Food and Drug Administration-approved electrophoresis system (Lipoprint, Quantimetrix), which separates lipoproteins based on size and measures the cholesterol concentrations in each fraction.…”

Section: Anthropometrics and Biochemistrymentioning

confidence: 99%

White Adipose Tissue Apolipoprotein C-I Secretion in Relation to Delayed Plasma Clearance of Dietary Fat in Humans

Wassef

Salem

Bissonnette

et al. 2012

ATVB

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Objective-White adipose tissue (WAT) dysfunction is characterized by delayed clearance of dietary triglyceride-rich lipoproteins (TRL). We reported that apolipoprotein (apo) C-I, a transferable apolipoprotein that inhibits lipoprotein lipase activity when bound to TRL, was produced by a human adipocyte model. Thus, we aimed to determine whether increased WAT apoC-I secretion is related to delayed dietary fat clearance in humans. Methods and Results-After the ingestion of a 13 C-triolein-labeled high-fat meal, postmenopausal obese women with highfasting WAT apoC-I secretion (median >0.81 μmol/L per g/4 hours, n=9) had delayed postprandial plasma clearance of 13 C-triglyceride and 13 C-nonesterified fatty acids over 6 hours compared with controls. WAT apoC-I secretion over 4 hours correlated with fasting total and non-high-density lipoprotein apoC-I but not with high-density lipoprotein apoC-I and was the primary predictor of 4-hour postprandial increases in TRL apoC-I. Correction for TRL apoC-I eliminated the association of WAT apoC-I with 6-hour area under the curve of plasma 13 C-triglyceride; correction for insulin sensitivity or inflammation did not. Finally, in addition to apoC-I, WAT secreted considerable amount of apoC-II, apoC-III, and apoE over 24 hours; however, only WAT apoC-I secretion was associated with 6-hour area under the curve of plasma 13 C-triglyceride. Conclusion-Increased

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Section: Anthropometrics and Biochemistrymentioning

confidence: 99%

White Adipose Tissue Apolipoprotein C-I Secretion in Relation to Delayed Plasma Clearance of Dietary Fat in Humans

Wassef

Salem

Bissonnette

et al. 2012

ATVB

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“…We tested the muscle insulin resistance index in a more homogeneous population of 113 nondiabetic postmenopausal overweight and obese women (aged 57.7 Ϯ 0.5 years, BMI 32.4 Ϯ 0.4 kg/m 2 ) who were recruited from the Department of Nutrition at the University of Montreal for a weight-loss study (3). This population is at high risk for insulin resistance.…”

mentioning

confidence: 99%

Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test

et al. 2007

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“…As described previously, 18,19 women were included in the study if they met the following criteria: (1) cessation of menstruation for more than 1 year and a follicle-stimulating hormone level X30 U l À1 , (2) sedentary (o2 h a week of structured exercise), (3) non-smokers, (4) free of known inflammatory diseases, (5) no use of hormone replacement therapy and (6) BMI X27 kg/m 2 . On physical examination or biological testing, all participants had no history or evidence of cardiovascular diseases, peripheral vascular diseases or stroke, diabetes (fasting serum glucose o7.0 mmol l À1 and 2-h post 75 g oral glucose tolerance test (OGTT) o11.0 mmol l À1 ), orthopedic limitations, weight fluctuation in the past 3 months ( ± 2 kg), thyroid or pituitary diseases, infection (tested by medical questionnaire and complete blood count) and medication that could affect cardiovascular function and/or metabolism.…”

Section: Participantsmentioning

confidence: 99%

Body fat distribution modulates insulin sensitivity in post-menopausal overweight and obese women: a MONET study

et al. 2008

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Objective: Central fat mass (CFM) correlates with insulin resistance and increases the risk of type 2 diabetes and cardiovascular complications. On the other hand, increased peripheral fat mass (PFM) is associated with higher insulin sensitivity. Thus, we examined the contribution of adipose tissue distribution, as assessed by the PFM/CFM ratio, to insulin sensitivity in overweight and obese postmenopausal women. Design and methods: A total of 124 nondiabetic overweight and obese postmenopausal women underwent an oral glucose tolerance test (OGTT) and a hyperinsulinemic/euglycemic (HI) clamp. Body composition was determined using computed tomography for visceral adipose tissue (VAT) and dual X-ray absorptiometry for fat mass, lean body mass and their respective proportions. Participants were divided by tertiles of the PFM/CFM ratio. Results: Participants with preferential CFM (group 1) had higher fasting insulin levels and insulin area under the curve (AUC) during OGTT, as well as lower glucose infusion rates during the HI clamp, whether it was expressed per kg of body weight (M) or per kg of fat-free mass (Mm), compared with the other two groups. The PFM/CFM ratio also correlated significantly with fasting insulin (r ¼ À0.32, Po0.001), the insulin AUC (r ¼ À0.42 Po0.001), M (r ¼ 0.39 Po0.001) and Mm (r ¼ 0.37 Po0.001). Using hierarchical regression, we demonstrated that the PFM/CFM ratio was an independent predictor of insulin AUC, M and Mm and that its sequential addition to CFM and VAT improved significantly the predictive value of the model for insulin sensitivity for all variables except fasting insulin. Conclusion: The PFM/CFM ratio, which integrates the antagonistic effects of both central and peripheral depots on insulin sensitivity, added substantially to the prediction of insulin sensitivity over VAT and CFM alone.

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Relationship between the hyperinsulinemic–euglycaemic clamp and a new simple index assessing insulin sensitivity in overweight and obese postmenopausal women

Cited by 66 publications

References 19 publications

White Adipose Tissue Apolipoprotein C-I Secretion in Relation to Delayed Plasma Clearance of Dietary Fat in Humans

White Adipose Tissue Apolipoprotein C-I Secretion in Relation to Delayed Plasma Clearance of Dietary Fat in Humans

Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test

Body fat distribution modulates insulin sensitivity in post-menopausal overweight and obese women: a MONET study

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