Relationship between Serum Vascular Endothelial Growth Factor Levels and Stages of Diabetic Retinopathy and Other Biomarkers

Abu-Yaghi, Nakhleh; Tarboush, N M Abu; Abojaradeh, Ala M; Al-Akily, Amal Saleh; Abdo, Esra'a M; Emoush, Laith O

doi:10.1155/2020/8480193

Cited by 14 publications

(15 citation statements)

References 43 publications

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“…In addition to the SRGN level, biomarkers such as FBG level and HbA1c level showed statistically significant differences among the three groups. This finding was consistent with the previously reported HbA1c level associated with the severity of DR, and the FBG level was also associated with DR's occurrence 35. We further used ROC analysis to analyze the diagnostic value of SRGN for DR. As expected, SRGN can differentiate between DR and T2DM patients, and healthy populations with the AUC results from all are higher than 0.8.…”

supporting

confidence: 90%

The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy

Wang¹,

Yin²,

Wang³

2020

Clinical Laboratory Analysis

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supporting

confidence: 90%

The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy

Wang¹,

Yin²,

Wang³

2020

Clinical Laboratory Analysis

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“…Many studies have found that VEGF is involved in the pathogenesis of diabetic complications [20], [21]. As we know that hyperglycemia-induced diacylglycerol, a lipid molecule, activates protein kinase C in the vascular tissues, and then turn promotes VEGF signaling, resulting in diabetic microvascular complications [22].…”

Section: Discussionmentioning

confidence: 99%

The Role Vascular Endothelial Growth Factor, Control Glycemic, Lipid Profile, and Hypoxia-inducible Factor 1-Alpha at Type 2 Diabetic Patients in North Sumatera, Indonesia

Rusdiana

Widjaja

Amelia

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder whose prevalence continues to increase worldwide. Chronic hyperglycemia increases the area of hypoxia that can be measured by markers of hypoxia-inducible factor 1-alpha (HIF-1α) and endothelial cell damage by vascular endothelial growth factor (VEGF) secretion and the association of the course of diabetes mellitus, dyslipidemia is also a risk factor that can aggravate the condition. diabetes mellitus. AIM: The aim of this study was to correlate VEGF with HIF-1α and other metabolic markers in T2DM. METHODS: Examination such as blood pressure, height, and body mass index, and duration of diabetes were recorded. Laboratory examination like blood sugar levels and glycated hemoglobin (Hba1C) levels, lipid profile such as cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were evaluated by Paramitha Laboratory Clinic and VEGF and HIF-1α we examined by ELISA methods in the Integrated laboratory of Medical Faculty, Universitas Sumatera Utara. The study was done by cross-sectional analytic methods, among 135 patients with T2DM who were admitted from the various primary health-care centers in Medan city and surrounding areas in North Sumatera. The inclusion criteria of the samples were all the patients diagnosed with T2DM, both the sexes, and the exclusion criteria of the samples with T1DM and severe disease. The data of the samples were processed using a computer with the SPSS program. RESULTS: There was a positive significant correlation between VEGF with HIF-1α, with a strong correlation, and found a negative correlation between VEGF with fasting blood sugar and HDL (p < 0.005). CONCLUSION: By finding strongly and positive correlation between VEGF and HIF-1α, the samples of menunjukkan bahwa peningkatan konsentrasi VEGF meningkat selaras dengan peningkatan konsentrasi dari HIF-1α _dan ini menunjukkan bahwa proses angiogenesis pada sample sedang berlangsung sebagai mekanisme kompensasi pertahanan vascular.

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“…Using a 5% margin of error and a power of 90%, power analysis revealed that a minimum of 20 DR patients would be needed to detect statistical significance in comparison to non-DR controls. 17 , 18 …”

Section: Methodsmentioning

confidence: 99%

“…Data provided by participants as well as information regarding required investigations have been verified through reviewing participants’ hospital records. 17 , 18 The second section of the questionnaire evaluated patients’ practices by asking participants about the following parameters: frequency of physical exercise, regular weight checkup, DM diet status, level of compliance to diet, having a glucose checking device at home, frequency of glucose checking, periodic annual visit to the ophthalmologist, and the cause of the first clinic visit. The questionnaire’s final section evaluated patients’ awareness about DM and DR.…”

Section: Methodsmentioning

confidence: 99%

Evaluating Awareness and Practices Towards Diabetes and Diabetic Retinopathy in Adult Patients Attending the Eye Clinic in a Tertiary Academic Hospital in Jordan

Khatib¹,

Tarboush²,

Abu-Yaghi³

et al. 2021

OPTH

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Aim and Background Awareness of diabetes mellitus (DM) and its complications, particularly diabetic retinopathy (DR), is one of the main factors of early detection and improved management. This study aims to assess the level of awareness of DM type 2 complications in a cohort of Jordanian patients, with special emphasis on DR. Methods A total of 176 consecutive patients with DM type 2 attending the ophthalmology clinic at Jordan University Hospital were included in the study. Each participant responded to a questionnaire which assessed their awareness and behaviors towards DM type 2 and DR. Results A total of 176 individuals with diabetes responded to the invitation to participate. They were 93 (52.8%) males and 83 (47.2%) females. Mean age (±SEM) for the study population was 60.6 (±0.82) years. Of all participants, 93.8% were aware that diabetes can affect the eyes. Only 4.5% reported that DR could occur without symptoms and/or loss of vision. Symptoms affecting the eyes were the main cause behind attending the ophthalmology clinic in 60.8% of the cases. The awareness score of participants for DM and DR ranged from 4 to 15 out of 20 with a mean score of 11.4/20. Statistically significant relationships of awareness mean score were observed with gender, educational level, employment status, insurance status, Hemoglobin (Hb) A1c level, and dyslipidemia as a co-morbidity (p<0.05). Binary logistic regression revealed disease duration and HbA1c as the main predictive factors of having DR. Conclusion Among this cohort of Jordanian individuals with diabetes, awareness towards DM and DR was relatively low, and patient practices did not correlate with perceived awareness. Awareness scores correlated with HbA1c readings and higher educational levels among other variables. Emphasis on communication strategies and patient education is essential in establishing efficient screening programs and effective strategies to curtail visual impairment and other complications of the diabetes pandemic.

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Relationship between Serum Vascular Endothelial Growth Factor Levels and Stages of Diabetic Retinopathy and Other Biomarkers

Cited by 14 publications

References 43 publications

The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy

The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy

The Role Vascular Endothelial Growth Factor, Control Glycemic, Lipid Profile, and Hypoxia-inducible Factor 1-Alpha at Type 2 Diabetic Patients in North Sumatera, Indonesia

Evaluating Awareness and Practices Towards Diabetes and Diabetic Retinopathy in Adult Patients Attending the Eye Clinic in a Tertiary Academic Hospital in Jordan

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