Relationship between serum selenium, sociodemographic variables, other trace elements and lipid profile in an adult Spanish population

González-Estecha, Montserrat; Palazón-Bru, Irene; Bodas-Pinedo, Andrés; Trasobares, Elena M.; Palazón‐Bru, Antonio; Fuentes, Manuel; Cuadrado-Cenzual, Ma Ángeles; Manuel, Elpidio Calvo

doi:10.1016/j.jtemb.2016.12.002

Cited by 33 publications

(15 citation statements)

References 85 publications

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“…Higher risks of dyslipidemia were associated with higher circulating Se concentrations in the observation trials from all the three times of National Health and Nutrition Examination Survey conducted between 1988–2012 in US [49–51], as well as from the populations of Lebanon [52], Taiwan [53], Britain [54], Finland [55], and Spain [56, 57]. But results from the Se supplementation trials were inconsistent, similar to those for the glucose metabolism.…”

Section: Diet-mediated Gpx1 Expression On Glucose and Lipid Metabolismmentioning

confidence: 99%

Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases

Huang¹,

Zhou

et al. 2018

Free Radical Biology and Medicine

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Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. While past research explored regulations of gene expression and biochemical function of this selenoperoxidase, GPX1 has recently been implicated in the onset and development of chronic diseases. Clinical data have shown associations of human GPX1 gene variants with elevated risks of diabetes. Knockout and overexpression of Gpx1 in mice may induce types 1 and 2 diabetes-like phenotypes, respectively. This review assembles the latest advances in this new field of selenium biology, and attempts to postulate signal and molecular mechanisms mediating the role of GPX1 in glucose and lipid metabolism-related diseases. Potential therapies by harnessing the beneficial effects of this ubiquitous redox-modulating enzyme are briefly discussed.

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Section: Diet-mediated Gpx1 Expression On Glucose and Lipid Metabolismmentioning

confidence: 99%

Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases

Huang¹,

Zhou

et al. 2018

Free Radical Biology and Medicine

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“…Regarding the association of selenium with total cholesterol and LDL-c, some studies show a direct association in the general population [51,52], while others display a negative correlation [53,54] or no association at all [55]. This inconsistency may be due to the sample size or even the lack of adjustment for confounding variables.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status Related to Selenium in Patients With Ataxia-Telangiectasia - A Case Control Study: an Association With Oxidative Stress and Risk of Atherosclerosis

Andrade¹,

Souza²,

Fonseca³

et al. 2020

Preprint

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Introduction: Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium (Se) is a trace element related to protection against damage caused by oxidative stress; it is postulated that adequate consumption reduces the risk of some chronic diseases. Objective: To describe the concentrations of Se and glutathione peroxidase (GPx) in patients with A-T, to relate them to markers of the lipid profile. Methods: We evaluated, through a controlled cross-sectional study, 22 A-T patients matched by sex and age with healthy individuals, conjointly evaluating: nutritional status, food intake, serum selenium, glutathione peroxidase (activity), lipid metabolism biomarkers, inflammation and lipid. Results: The median age in the A-T group was 12.2 years. A-T patients had greater impairment of lean body mass and GPx activity as well as lower abdominal circumference. A more atherogenic lipid profile was observed with higher concentrations of total cholesterol, non-HDL cholesterol, LDLox, Apo B, Apo B / Apo A-1 and LDL / HDL ratio; while a lower value was observed in the Apo A-1 / HDL ratio. It was also in the A-T group that statistical difference was detected in the three markers of liver function AST, ALT and GGT. In regard to food intake, A-T patients had lower values of carbohydrate, protein, monounsaturated fat, trans fat, and Se. Conclusion: The study showed cardiovascular risk in A-T patients. A-T patients appear to be at increased risk of reduced nutritional status, impaired liver function, dyslipidemia and inflammation.

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“…Regarding the association of selenium with total cholesterol and LDL-c, some studies show a direct association in the general population [48,49], while others display a negative correlation [50,51] or no association at all [52]. This inconsistency may be due to the sample size or even the lack of adjustment for confounding variables.…”

Section: Table 3 Comparison Of Biochemical Variables Of A-t Patients mentioning

confidence: 99%

Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Andrade

Souza

Fonseca

et al. 2021

Orphanet J Rare Dis

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Introduction Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress. Objective To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers. Methods This is a cross-sectional and controlled study evaluating 22 A-T patients (age median, 12.2 years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers. Results Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6 μg/L (43.2–57.0) vs 54.6 (45.2–62.6) μg/dL, p = 0.242]. Nine of A-T patients (41%) had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I1, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L vs 2.8 µg/L, p = 0.029] and lower Apo-A-I1/HDL-c and glutathione peroxidase activity [7300 U/L vs 8686 U/L, p = 0.005]. Selenium levels were influenced, in both groups, independently, by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC = 0.849) and ALT (AUC = 0.854) were the variables that showed the greatest discriminatory power between groups. Conclusion In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.

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Relationship between serum selenium, sociodemographic variables, other trace elements and lipid profile in an adult Spanish population

Cited by 33 publications

References 85 publications

Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases

Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases

Nutritional Status Related to Selenium in Patients With Ataxia-Telangiectasia - A Case Control Study: an Association With Oxidative Stress and Risk of Atherosclerosis

Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

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