Relationship between serum prostate-specific antigen and age in cadavers

Tsuboi, Hajime; Miyamori, Daisuke; Ishikawa, Noboru; Ichioka, Hiroaki; Ikegaya, Hiroshi

doi:10.1177/2050312120958212

Cited by 6 publications

(9 citation statements)

References 29 publications

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“…But we cannot compare the current results with that study because they examined PSA levels in the blood collected from living patients and then they left specimens for various intervals. Tsuboi et al (2020) found that there was no statistically significant correlation between serum PSA levels and postmortem interval whether regardless of age at death or with considered the age of cadavers. They revealed that PSA is a stable material that is not affected by the putrefaction or the environment of the corpses.…”

Section: Discussionmentioning

confidence: 78%

“…In the realm of forensic medicine, however, it is well understood that the detection of PSA in sperm collected from a sexual assault victim establishes the existence of sperm. The cause of death did not affect the levels of prostate-specific antigen in postmortem serum (Tsuboi et al, 2020).…”

Section: Introductionmentioning

confidence: 79%

“…PSA is a glycoprotein with protease activity that has 237 amino acids. PSA is produced particularly in the ductal epithelial cells of the prostate gland and, when secreted in sperm, has a function in enhancing sperm motility (Tsuboi et al, 2020). PSA has been found in numerous physiological 0 fluids and tissues, despite being abundant in prostatic tissue and sperm so it is not particular to the prostate.…”

Section: Introductionmentioning

confidence: 99%

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Prostatic estimation of time passed since death; oxidative stress markers, histological and immunohistochemical examination (an experimental study)

Ali

Ahmed²

2023

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction: One of the most essential duties in forensic medicine is determining the postmortem interval. Objectives: The study's purpose is to estimate time passed since death in relation to oxidative stress markers, histopathological changes, and prostatic specific antigen in the prostate. Methods: Fifty mature male albino rats were classified into 5 main groups. Rats were used for determining postmortem changes and oxidative stress markers at five different postmortem intervals (0, 1, 5, 10, 15 days) with prostatic specific antigen (PSA) immunohistochemistry in the prostate. Results: Prostatic gland oxidant parameters (MDA, NO) revealed a significant increase while its antioxidant parameters (GSH, SOD) showed a significant decrease with increased postmortem time. The prostate gland showed normal histology at 0 hours postmortem (PM). While, at 1 day, it revealed minimal autolysis (<5%). Starting from 5 days, moderate autolysis (10-50%) was seen. Ten to fifteen days, moderate to severe autolysis (≥50%) appeared in most of the samples. Staining for PSA showed high expression (++) at 0 hours PM. Moreover, a significant decrease in the amount of PSA's stained areas that revealed low expression (+) was detected at 1 and 5 days PM. Negative (−) or no immunoreactivity for PSA has been detected at 10 and 15 days PM. Conclusion: Prostatespecific antigen proved to be a useful parameter consistent with the histopathological changes for the estimation of postmortem interval from the prostate. It is approved that the derived oxidative stress markers equations can be helpful in detecting the postmortem interval in forensic science.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Prostatic estimation of time passed since death; oxidative stress markers, histological and immunohistochemical examination (an experimental study)

Ali

Ahmed²

2023

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…Figure 3 also showed the predicted values of age and the 95% prediction intervals. [38][39][40][41][42] . Especially skin imaging and ultrasonography are very elementary and can be used by non-experts at scenes 38,41 .…”

Section: Resultsmentioning

confidence: 99%

A Raman Algorithm to Estimate Human Age From Protein Structural Variations in Autopsy Skin Samples: the Proteins’ Biological Clock

Miyamori

Uemura

Zhu

et al. 2020

Preprint

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The recent increase of the number of unidentified cadavers has become a serious problem in the world. As a simple and objective method for age estimation, we attempted to utilize Raman spectrometry for forensic identification. Raman spectroscopy is an optical-based vibrational spectroscopic technique that provides detailed information about molecular composition and structure. Building upon our previous proof-of-concept study, Raman spectra of abdominal skin sample were measured in 132 autopsy cases and protein-folding intensity ratio (RPF) was calculated. There was a strong negative correlation between age and RPF with a Pearson correlation coefficient r = 0.878. The results of cross validation suggested that Model 2 (the square of RPF) is the best model with lowest mean squared error (127.9) and highest coefficient of determination (0.743) among the four models. Our results indicate that the there is a high correlation between the age and RPF. The Raman biological clock of protein folding can be used as a simple and objective forensic age estimation method of unidentified cadavers.

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“…We previously reported that postmortem serum prostate-specific antigen (PSA) level and prostate volume correlate with age and discussed the use of PSA in an objective age estimation [4].…”

Section: Introductionmentioning

confidence: 99%

Nose size indicates maximum penile length

Ikegaya

Suzuki

Kondou

et al. 2021

Basic Clin. Androl.

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Background In a previous report, we investigated whether the size of male genitalia similarly exposed to serum testosterone during aging could change with age and found that penile length almost stopped increasing during adolescence and decreased in older males. In this report, to determine what factors other than age are related to penile length, we performed a multivariate analysis of the relationships between stretched penile length (SPL) and other measurements of genital organs, nose size, height and body weight in 126 adults in their 30s–50s. Results The most highly correlated factor with SPL was flaccid penile length (r = 0.565, P < 0.0001). The next highest correlation was nose size (r = 0.564, P < 0.0001). The penile stretched rate correlated with FPL (r = − 0.690, P < 0.0001) but not with SPL or penile circumference. Conclusions The fact that nose size is related to SPL indicates that penile length may not be determined by age, height or body weight but has already been determined before birth.

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Relationship between serum prostate-specific antigen and age in cadavers

Cited by 6 publications

References 29 publications

Prostatic estimation of time passed since death; oxidative stress markers, histological and immunohistochemical examination (an experimental study)

Prostatic estimation of time passed since death; oxidative stress markers, histological and immunohistochemical examination (an experimental study)

A Raman Algorithm to Estimate Human Age From Protein Structural Variations in Autopsy Skin Samples: the Proteins’ Biological Clock

Nose size indicates maximum penile length

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