2018
DOI: 10.1590/0101-60830000000163 View full text |Buy / Rent full text
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Abstract: Background: Panic disorder has long been associated with the changes in various neurotransmitters, such as Neuropeptide-S (NPS). Objective: In this study we aimed to determine whether there is a relationship between blood NPS levels and panic disorder. Methods: Twenty nine patients with panic disorder and thirty two healthy control subjects who were age and gender matched were enrolled to the study. Blood samples were taken from participants and plasma NPS levels were quantified by using an ELISA kit. Results:… Show more

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“…The study was limited only to male participants to reduce the risk of potential gender differences in NPS levels, which could not be corrected reliably between relatively small groups. Previous NPS studies with a limited number of participants clearly indicated difficulties in interpreting the results in relation to gender [ 19 , 20 , 25 ]. Moreover, PANSS results can also be influenced by gender differences [ 35 ].…”
Section: Methodsmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…The study was limited only to male participants to reduce the risk of potential gender differences in NPS levels, which could not be corrected reliably between relatively small groups. Previous NPS studies with a limited number of participants clearly indicated difficulties in interpreting the results in relation to gender [ 19 , 20 , 25 ]. Moreover, PANSS results can also be influenced by gender differences [ 35 ].…”
Section: Methodsmentioning
“…Specifically, the anxiolytic effect is not related to excessive sedation, but rather to an increase in activity (“novel activating anxiolytic”), which is a pharmacologically unique feature [ 17 ]. The median plasma NPS level was found to be significantly higher in generalized anxiety disorder (GAD) patients [ 19 ]. While NPS may have a beneficial effect on anxiety, no direct effect on depression has yet been demonstrated in animal models [ 20 ].…”
Section: Introductionmentioning
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