Relationship between obstructive sleep apnea and 30-day mortality among patients with pulmonary embolism

Abstract

Background:Pulmonary embolism (PE) is the most life-threatening form of venous thrombosis which causes the majority of mortalities in this category. Obstructive sleep apnea (OSA) has been indicated as one of the risk factors for thromboembolism because of hemostatic alterations. The present study was designed to seek for the relationship between OSA and 30-day mortality of patients with PE.Materials and Methods:This prospective cohort study was conducted among 137 consecutive patients referred to hospital with symptoms of PE and preliminary stable hemodynamic. Confirmation of PE was made by multislice computed tomography pulmonary angiography and in the case of contraindication; V/Q lung scan and Doppler sonography were done. A STOP-Bang Questionnaire was used to determine patients with high- and low-risk of OSA. Patients were followed up for 1-month, and their survivals were recorded.Results:This study showed that there was no relationship between OSA and 30-day mortality (P = 0.389). Chronic kidney disease (P = 0.004), hypertension (P = 0.003), main thrombus (P = 0.004), and segmental thrombus (P = 0.022) were associated with 30-day mortality. In the logistic regression analysis, history of chronic kidney disease was diagnosed as a risk factor for 30-day mortality among the PE patients (P = 0.029, odds ratio = 4.93).Conclusion:Results of this study showed 30-day mortality was not affected by OSA directly. In fact, it was affected by complications of OSA such as hypertension and thrombus. Also, positive history of chronic kidney disease increased the risk of 30-day mortality.

Association of irritable bowel syndrome and sleep apnea in patients referred to sleep laboratory

“…Sleep apnea, a prevalent sleep disorder, has been considered as a potential cause, which yields to acute and sustained activation of the sympathetic nervous system. [ 5 6 ] In accordance with the epidemiological studies, which was implemented from 1993 to 2013, the prevalence of sleep apnea in males and females were 22% and 17%, respectively. Furthermore, these studies documented that the disease prevalence escalated with time.…”

“…[56] In accordance with the epidemiological studies, which was implemented from 1993 to 2013, the prevalence of sleep apnea in males and females were 22% and 17%, respectively. Furthermore, these studies documented that the disease prevalence escalated with time.…”

Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality

“…This explanation could justify the findings of Joshi et al 26 , who reported prevalent OSA to be associated with lower IHM in PE patients. The same authors also suggested that OSA could lead to increased hemoglobin levels resulting from hypoxemia, which may confer a protective effect in acute PE by preventing hypoxia from worsening 14 , 26 .…”

“…OSA seems to increase the risk of PE and or recurrences 13 , yet data on the association between OSA and prognosis of PE patients are contradictory. Thus, some authors found no association between OSA and 30-day mortality in PE patients 14 , whereas others have suggested that OSA is a predictor of PE-related death 15 .…”

Comparison of support vector machine based on genetic algorithm with logistic regression to diagnose obstructive sleep apnea

“…OSA is associated with the incidence of various diseases. [ 3 4 5 ] Due to the fact that it induces sleep and fatigue during the day, this syndrome increases the risk of car accidents 2–7 times. [ 6 ] OSA is a common disease that affects 2% of women and 4% of men in Western society.…”